AU2001239884B2 - Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins and screening methods for modulators - Google Patents
Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins and screening methods for modulators Download PDFInfo
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/069—Vascular Endothelial cells
- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
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- C—CHEMISTRY; METALLURGY
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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| US6965010B2 (en) * | 2000-02-25 | 2005-11-15 | Licentia, Ltd. | Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins |
| CA2410887C (en) | 2000-06-02 | 2012-07-24 | Bracco Research Usa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
| US8263739B2 (en) | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
| EP1323736A4 (en) * | 2000-08-10 | 2005-08-24 | Masabumi Shibuya | CHIMERIC GROWTH FACTOR OF HUMAN TYPE VASCULAR ENDOTHELIAL CELLS |
| DE60219419T2 (de) * | 2001-01-19 | 2007-08-16 | Ludwig Institute For Cancer Research | Flt4 (vegfr-3) als ein ziel für krebsdarstellung und anti-krebs-behandlung |
| US20040132675A1 (en) * | 2002-02-08 | 2004-07-08 | Calvin Kuo | Method for treating cancer and increasing hematocrit levels |
| JP4303105B2 (ja) * | 2001-06-28 | 2009-07-29 | ドマンティス リミテッド | 二重特異性リガンドとその利用 |
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| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
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| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| AU2003228762A1 (en) * | 2002-05-03 | 2003-11-17 | Ludwig Institute For Cancer Research | Preventing secondary lymphedema with vegf-d dna |
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| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| AU2003290330A1 (en) * | 2002-12-27 | 2004-07-22 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
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| US20050043235A1 (en) * | 2003-06-12 | 2005-02-24 | Kari Alitalo | Use of VEGF-C or VEGF-D in reconstructive surgery |
| DE602005027673D1 (de) | 2004-03-05 | 2011-06-09 | Vegenics Pty Ltd | Materialien und verfahren für wachstumsfaktorbindende konstrukte |
| EP1773373A4 (en) * | 2004-03-08 | 2010-11-17 | Ludwig Inst Cancer Res | METHOD FOR MODULATING, REGULATING AND / OR STABILIZING ANGIOGENESIS |
| AU2005269527B2 (en) | 2004-07-26 | 2011-12-01 | Pfenex Inc. | Process for improved protein expression by strain engineering |
| US7553496B2 (en) * | 2004-12-21 | 2009-06-30 | University Of Kentucky Research Foundation | VEGF-A as an inhibitor of angiogenesis and methods of using same |
| US7893244B2 (en) * | 2005-04-12 | 2011-02-22 | Intradigm Corporation | Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases |
| KR20080041145A (ko) * | 2005-04-12 | 2008-05-09 | 인트라디그엠 코오포레이션 | 암 및 다른 신생혈관증식 질환을 치료하기 위한 ＲＮＡｉ치료제의 조성물 및 방법 |
| AU2006279462A1 (en) | 2005-08-15 | 2007-02-22 | Vegenics Limited | Modified VEGF and PDGF with improved angiogenic properties |
| JP2009519011A (ja) * | 2005-12-01 | 2009-05-14 | ドマンティス リミテッド | インターロイキン１受容体１型に結合する非競合ドメイン抗体フォーマット |
| US20090214496A1 (en) * | 2006-01-30 | 2009-08-27 | Licentia Ltd. | Bmx/etk tyrosine kinase gene therapy materials and methods |
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| US20080267924A1 (en) * | 2007-02-07 | 2008-10-30 | Vegenics Limited | Autologous lymph node transfer in combination with vegf-c or vegf-d growth factor therapy to treat secondary lymphedema and to improve reconstructive surgery |
| EP2615172A1 (en) | 2007-04-27 | 2013-07-17 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
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| Publication number | Publication date |
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| CA2400948A1 (en) | 2001-08-30 |
| AU2001239884C1 (en) | 2001-09-03 |
| US20050267024A1 (en) | 2005-12-01 |
| ATE377081T1 (de) | 2007-11-15 |
| US20080058263A1 (en) | 2008-03-06 |
| DE60131146D1 (de) | 2007-12-13 |
| US6965010B2 (en) | 2005-11-15 |
| AU3988401A (en) | 2001-09-03 |
| JP4981229B2 (ja) | 2012-07-18 |
| US20020151680A1 (en) | 2002-10-17 |
| EP1259626A2 (en) | 2002-11-27 |
| JP2004507208A (ja) | 2004-03-11 |
| US7902149B2 (en) | 2011-03-08 |
| US8278098B2 (en) | 2012-10-02 |
| US20090318352A1 (en) | 2009-12-24 |
| WO2001062942A2 (en) | 2001-08-30 |
| US20110207664A1 (en) | 2011-08-25 |
| DE60131146T2 (de) | 2008-03-06 |
| AU2006235995A1 (en) | 2006-12-07 |
| US7309604B2 (en) | 2007-12-18 |
| US7566566B2 (en) | 2009-07-28 |
| WO2001062942A3 (en) | 2002-03-21 |
| EP1259626B1 (en) | 2007-10-31 |
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