AU2001231006A1 - Statin-type bone growth stimulators - Google Patents

Statin-type bone growth stimulators

Info

Publication number
AU2001231006A1
AU2001231006A1 AU2001231006A AU3100601A AU2001231006A1 AU 2001231006 A1 AU2001231006 A1 AU 2001231006A1 AU 2001231006 A AU2001231006 A AU 2001231006A AU 3100601 A AU3100601 A AU 3100601A AU 2001231006 A1 AU2001231006 A1 AU 2001231006A1
Authority
AU
Australia
Prior art keywords
bone
compounds
compound
alkyl
heteroaromatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001231006A
Other languages
English (en)
Inventor
Gregory R Mundy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OsteoScreen Inc
Original Assignee
OsteoScreen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OsteoScreen Inc filed Critical OsteoScreen Inc
Publication of AU2001231006A1 publication Critical patent/AU2001231006A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
AU2001231006A 2000-01-20 2001-01-19 Statin-type bone growth stimulators Abandoned AU2001231006A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/488,380 US6376476B1 (en) 1996-12-13 2000-01-20 Isoprenoid pathway inhibitors for stimulating bone growth
US09488380 2000-01-20
PCT/US2001/001888 WO2001052829A2 (fr) 2000-01-20 2001-01-19 Stimulateurs de croissance osseuse de type statine

Publications (1)

Publication Number Publication Date
AU2001231006A1 true AU2001231006A1 (en) 2001-07-31

Family

ID=23939512

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001231006A Abandoned AU2001231006A1 (en) 2000-01-20 2001-01-19 Statin-type bone growth stimulators

Country Status (6)

Country Link
US (4) US6376476B1 (fr)
EP (1) EP1253922A2 (fr)
JP (1) JP2003527353A (fr)
AU (1) AU2001231006A1 (fr)
CA (1) CA2397659A1 (fr)
WO (2) WO2001052829A2 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376476B1 (en) * 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
US6410521B1 (en) 1998-06-12 2002-06-25 Osteoscreen, Inc. Nutritional supplements for stimulating bone growth
US6902721B1 (en) * 1998-07-10 2005-06-07 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone growth
US7192445B2 (en) * 2000-12-06 2007-03-20 Astra Tech Ab Medical prosthetic devices and implants having improved biocompatibility
JP2002370982A (ja) * 2001-06-12 2002-12-24 Kowa Co 骨形成促進剤
EP1291017A3 (fr) * 2001-09-10 2003-07-02 Warner-Lambert Company Utilisation de statines pour prévenir la formation d'osteoclastes
JP2005527209A (ja) * 2002-04-22 2005-09-15 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター
US7041309B2 (en) * 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
US8876532B2 (en) 2002-07-31 2014-11-04 Dentsply International Inc. Bone repair putty
WO2004091626A1 (fr) * 2003-04-07 2004-10-28 Osteoscreen, Inc. Stimulation de la croissance osseuse avec no/statine et autres combinaisons modulatoires
FI20045223A (fi) * 2004-06-15 2005-12-16 Bioretec Oy Monitoiminen biohajoava komposiitti ja kirurginen implantti, joka käsittää mainitun komposiitin
US7250444B2 (en) 2003-08-11 2007-07-31 Pfizer Inc. Pyrrole-based HMG-CoA reductase inhibitors
JP2005060307A (ja) * 2003-08-12 2005-03-10 Pirumu:Kk 骨造成剤
US20050074443A1 (en) * 2003-10-03 2005-04-07 Treadwell Benjamin V. Methods of attenuating autoimmune disease and compositions useful therefor
GB0327742D0 (en) * 2003-11-28 2003-12-31 Isis Innovation Novel uses of known drugs
US7163945B2 (en) * 2004-04-29 2007-01-16 Pharmix Corp. Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20050272770A1 (en) * 2004-04-29 2005-12-08 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20050282883A1 (en) * 2004-04-29 2005-12-22 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US7199126B2 (en) * 2004-04-29 2007-04-03 Pharmix Corporation Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US7183285B2 (en) * 2004-04-29 2007-02-27 Pharmix Corp. Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20060084695A1 (en) * 2004-04-29 2006-04-20 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
EP1591133A1 (fr) * 2004-04-30 2005-11-02 Synthes Implants ayant une activité biologique
US7648965B2 (en) * 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US7531518B2 (en) * 2004-05-14 2009-05-12 Unigene Laboratories Inc. Method for fostering bone formation and preservation
AU2005331907B2 (en) * 2004-05-14 2010-04-22 Unigene Laboratories, Inc. Method for fostering bone formation and preservation
US20060111436A1 (en) * 2004-11-23 2006-05-25 John Griffin Compositions and treatments for modulating kinase and/or HMG-CoA reductase
EP1879608A4 (fr) * 2005-05-11 2009-11-11 Unigene Lab Inc Methode pour stimuler la formation et la preservation des os
US20060293667A1 (en) * 2005-05-19 2006-12-28 Agnes Vignery Bone implant device and methods of using same
EP1996118A4 (fr) * 2006-03-07 2013-03-06 Osteoscreen Ip Llc RENFORCEMENT DE L'OS ET DU CARTILAGE PAR UN INHIBITEUR DE LA HMG Co-A RÉDUCTASE
WO2009093240A2 (fr) * 2008-01-24 2009-07-30 Ademex Ltd. Compositions d'érythropoiétine et de fibronectine pour la régénération osseuse
TWI483726B (zh) * 2010-01-04 2015-05-11 Food Industry Res & Dev Inst 新穎吡啶生物鹼、其製備方法及該等吡啶生物鹼之用途
US8877221B2 (en) 2010-10-27 2014-11-04 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same
US9107983B2 (en) 2010-10-27 2015-08-18 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising statins
CN102617533B (zh) * 2011-02-01 2014-08-27 北京北大维信生物科技有限公司 一种从红曲中分离的化合物、其制备方法及用途
WO2012170417A2 (fr) 2011-06-06 2012-12-13 Warsaw Orthopedic, Inc. Procédés et compositions pour améliorer la croissance osseuse comprenant une statine
EP2887932B1 (fr) * 2012-08-22 2020-05-20 Rosenberg Messina, David Rafael Utilisation de statines pour une parodontopathie et une régénération osseuse
CN102885797A (zh) * 2012-10-29 2013-01-23 福州海王福药制药有限公司 一种含匹伐他汀钙的组合物及其制备方法和应用
TWI542569B (zh) * 2015-02-11 2016-07-21 高雄醫學大學 ３，５－二羥基戊酸的類似物用於成骨作用
US11065262B2 (en) 2017-07-27 2021-07-20 Northwestern University Topical treatment of wounds with statins and cholesterol for scar reduction

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8530603D0 (en) 1985-12-12 1986-01-22 Leo Pharm Prod Ltd Chemical compounds
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
US5093363A (en) 1989-08-22 1992-03-03 Shionogi & Co., Ltd. 2,4,6-substituted phenol derivatives
US5316765A (en) 1989-09-07 1994-05-31 Karl Folkers Foundation For Biomedical And Clinical Research Use of coenzyme Q10 in combination with HMG-CoA reductase inhibitor therapies
US5258376A (en) 1989-11-22 1993-11-02 Bernstein Lawrence R Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones
US5128366A (en) 1990-07-05 1992-07-07 Shinogi & Co., Ltd. Pyrrole derivatives
JPH05163150A (ja) 1991-05-13 1993-06-29 E R Squibb & Sons Inc アテローム性動脈硬化症の抑制・治療剤
DK0554455T3 (da) 1991-06-19 1998-01-19 Shionogi & Co Optisk aktivt mellemprodukt og fremstilling deraf
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
ES2151508T3 (es) * 1992-05-13 2001-01-01 Us Health Empleo de inhibidores de reductasa 3-hidroxi-3-metilglutaril coenzima a como una modalidad en la terapia del cancer.
US5278153A (en) * 1992-05-18 1994-01-11 E. R. Squibb & Sons, Inc. Aryl and heteroaryl (phosphinylmethyl)phosphonate squalene synthetase inhibitors and method
EP0619305B1 (fr) 1993-02-05 1997-06-04 Teijin Limited Composé du type lactone et procédé pour leur préparation
US5280040A (en) 1993-03-11 1994-01-18 Zymogenetics, Inc. Methods for reducing bone loss using centchroman derivatives
US5403829A (en) 1993-03-24 1995-04-04 Leiras Oy Use of bisphosphonates in endo-osteal bone surgery
US5336687A (en) 1993-08-04 1994-08-09 American Home Products Corporation Inhibition of bone loss by 4-aryloxy-5-hydroxy-2(5H)-furanones
US5462932A (en) 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations
JP3566984B2 (ja) 1994-06-02 2004-09-15 帝人株式会社 骨形成促進剤
US5968983A (en) * 1994-10-05 1999-10-19 Nitrosystems, Inc Method and formulation for treating vascular disease
WO1996019501A1 (fr) * 1994-12-20 1996-06-27 Osteosa Inc. Modulateurs des fonctions des cellules osseuses et leurs utilisations
US5545661A (en) 1995-05-16 1996-08-13 Eli Lilly And Company Methods for inhibiting bone loss with bis-pyrone oxovanadium compounds
US6083690A (en) * 1995-06-02 2000-07-04 Osteoscreen, Inc. Methods and compositions for identifying osteogenic agents
HUP9802319A3 (en) 1995-10-23 1999-12-28 Zymogenetics Inc Seattle Pharmaceutical compositions for treatment of bone deficit conditions
JP3895792B2 (ja) * 1995-12-08 2007-03-22 プロスケリア・エス・ア・エス 骨形成促進剤
US5935607A (en) 1996-02-15 1999-08-10 Hadasit Medical Research Services And Development Company Ltd. Treatment of osteoporosis
US5902805A (en) * 1996-04-22 1999-05-11 L'oreal Method for treatment of acne and/or the effects of ageing using HMG-coenzyme A-reductase inhibitor and compositions for performing the same
JP2000514048A (ja) 1996-06-20 2000-10-24 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 薬理学的活性調製物を提供するための化合物および方法ならびにそれらの使用
US6046022A (en) * 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
US5965573A (en) * 1996-10-23 1999-10-12 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
WO1998017267A1 (fr) 1996-10-23 1998-04-30 Zymogenetics, Inc. Compositions et methodes pour traiter les etats associes a un deficit osseux
US5840752A (en) * 1996-11-21 1998-11-24 Henry; James P. Reduction of hair growth
US6376476B1 (en) * 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
US6080779A (en) * 1996-12-13 2000-06-27 Osteoscreen, Inc. Compositions and methods for stimulating bone growth
WO1998025460A1 (fr) * 1996-12-13 1998-06-18 Zymogenetics, Inc. Compositions visant a stimuler la croissance osseuse et methodes afferentes
WO1999045923A1 (fr) 1998-03-13 1999-09-16 Merck & Co., Inc. Methodes visant a bloquer la resorption osseuse
JP4592127B2 (ja) * 1999-03-30 2010-12-01 雪印乳業株式会社 骨吸収抑制剤
WO2001037876A2 (fr) 1999-11-24 2001-05-31 Bayer Aktiengesellschaft Procedes d'amelioration de conditions osseuses anormales
EP1322306A2 (fr) * 2000-09-19 2003-07-02 NovImmune S.A. Statines (inhibiteurs de la hmg-coa reductase) en tant que nouveau type d'agent immunomodulateur, immunosuppresseur et anti-inflammatoire
US20030229044A1 (en) * 2002-03-29 2003-12-11 Lawrence Steinman Use of statins and other immunomodulatory agents in the treatment of autoimmune disease
US8883148B2 (en) * 2002-04-26 2014-11-11 Asan Laboratories Company (Cayman), Limited Prevention of joint destruction
WO2003105752A2 (fr) * 2002-05-02 2003-12-24 Osteoscreen, Inc. Procedes et compositions stimulant la croissance osseuse a l'aide de l'oxyde nitrique liberant des conjugues de bisphosphonate

Also Published As

Publication number Publication date
US20040106675A1 (en) 2004-06-03
CA2397659A1 (fr) 2001-07-26
US7101907B2 (en) 2006-09-05
WO2001074180A1 (fr) 2001-10-11
US6642216B2 (en) 2003-11-04
WO2001052829A2 (fr) 2001-07-26
US6376476B1 (en) 2002-04-23
US20010034364A1 (en) 2001-10-25
EP1253922A2 (fr) 2002-11-06
JP2003527353A (ja) 2003-09-16
WO2001052829A3 (fr) 2002-05-02
US20050272801A1 (en) 2005-12-08

Similar Documents

Publication Publication Date Title
AU2001231006A1 (en) Statin-type bone growth stimulators
US6080779A (en) Compositions and methods for stimulating bone growth
AU729793B2 (en) Compositions and methods for stimulating bone growth
US6342514B1 (en) Compositions and methods for treating bone deficit conditions
US5994358A (en) Compositions and methods for treating bone deficit conditions
US6153631A (en) Compositions and methods for treating bone deficit conditions
US5922753A (en) Methods for treating bone deficit conditions with benzothiazole
US5919808A (en) Compositions and methods for treating bone deficit conditions
US6462019B1 (en) Inhibitors of proteasomal activity and production for stimulating bone growth
US5948776A (en) Compositions and methods for treating bone deficit conditions
US5965573A (en) Compositions and methods for treating bone deficit conditions
AU706262B2 (en) Compositions and methods for treating bone deficit conditions
WO1998025460A9 (fr) Compositions visant a stimuler la croissance osseuse et methodes afferentes
US6656904B2 (en) Inhibitors of proteasomal activity for stimulating bone and hair growth
US6413998B1 (en) Compositions and methods for treating bone deficit conditions
WO1997015308A9 (fr) Compositions et procedes pour le traitement des deficits osseux
US20040254238A1 (en) Bone growth stimulation with NO/statin and other NO modulating combinations
US6410521B1 (en) Nutritional supplements for stimulating bone growth
US20030181374A1 (en) Methods and compositions for stimulating bone growth using inhibitors of microtubule assembly
US5939444A (en) Compositions and methods for treating bone deficit conditions
US6017940A (en) Compositions and methods for treating bone deficit conditions
EP1609469A2 (fr) Compositions et méthodes pour stimuler la croissance osseuse
EP1267641A1 (fr) Supplements nutritionnels pour stimuler la croissance osseuse