AU1018688A - Paramagnetic complex salts, their preparation and their use in nmr-diagnostics - Google Patents

Paramagnetic complex salts, their preparation and their use in nmr-diagnostics

Info

Publication number
AU1018688A
AU1018688A AU10186/88A AU1018688A AU1018688A AU 1018688 A AU1018688 A AU 1018688A AU 10186/88 A AU10186/88 A AU 10186/88A AU 1018688 A AU1018688 A AU 1018688A AU 1018688 A AU1018688 A AU 1018688A
Authority
AU
Australia
Prior art keywords
numbers
preparation
diagnostics
nmr
see diagramm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU10186/88A
Other versions
AU601916B2 (en
Inventor
Heinz Dr. Gries
Douwe Dr. Rosenberg
Hanns-Joachim Dr. Weinmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6137999&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU1018688(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering AG filed Critical Schering AG
Publication of AU1018688A publication Critical patent/AU1018688A/en
Application granted granted Critical
Publication of AU601916B2 publication Critical patent/AU601916B2/en
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281—Means for the use of in vitro contrast agents

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. The use of at least one physiologically tolerable paramagnetic complex salt made from aminopolycarboxylic acids having the formulae I to IV see diagramm : EP0169299,P6,F1 N-hydroxyethyl-N,N',N'-ethylenediaminetriacetic acid (HEDTA), see diagramm : EP0169299,P6,F2 N,N,N',N",N"-diethylenetriaminepenta-acetic acid (DTPA), HOH2 C-CH2 N(CH2 COOH)2 N-hydroxyethylimino-diacetic acid, see diagramm : EP0169299,P6,F3 wherein m represents the numbers 1 to 4, n the numbers 0 to 2, R**1 a saturated or unsaturated hydrocarbon radical having from 4 to 12 hydrocarbon atoms or the group -CH2 -COOH, and from the ions of the lanthanide elements having the atomic numbers 57 to 70 or from the ions of the transition metals having the atomic numbers 21 to 29, 42 and 44 and, optionally from an inorganic base for the preparation of agents for NMR diagnostics.
AU10186/88A 1981-07-24 1988-01-08 Paramagnetic complex salts, their preparation and their use in nmr-diagnostics Expired AU601916B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE31299067 1981-07-24
DE3129906A DE3129906C3 (en) 1981-07-24 1981-07-24 Paramagnetic complex salts, their preparation and agents for use in NMR diagnostics

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU86330/82A Division AU566007B2 (en) 1981-07-24 1982-07-22 Paramagnetic complex salts and their use in nmr- diagnostics

Publications (2)

Publication Number Publication Date
AU1018688A true AU1018688A (en) 1988-04-28
AU601916B2 AU601916B2 (en) 1990-09-20

Family

ID=6137999

Family Applications (2)

Application Number Title Priority Date Filing Date
AU86330/82A Expired AU566007B2 (en) 1981-07-24 1982-07-22 Paramagnetic complex salts and their use in nmr- diagnostics
AU10186/88A Expired AU601916B2 (en) 1981-07-24 1988-01-08 Paramagnetic complex salts, their preparation and their use in nmr-diagnostics

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU86330/82A Expired AU566007B2 (en) 1981-07-24 1982-07-22 Paramagnetic complex salts and their use in nmr- diagnostics

Country Status (12)

Country Link
EP (2) EP0169299B1 (en)
JP (3) JPS5829718A (en)
AT (2) ATE18719T1 (en)
AU (2) AU566007B2 (en)
CA (2) CA1218597A (en)
DE (3) DE3129906C3 (en)
IE (1) IE53639B1 (en)
LU (1) LU88291I2 (en)
NL (1) NL930072I2 (en)
NO (2) NO164458C (en)
NZ (1) NZ201372A (en)
ZA (1) ZA825313B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
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AU612647B2 (en) * 1987-05-08 1991-07-18 Salutar, Inc. Manganese (II) chelate contrast agents and methods
US5360459A (en) 1991-05-13 1994-11-01 The Lubrizol Corporation Copper-containing organometallic complexes and concentrates and diesel fuels containing same
AU696166B2 (en) * 1993-11-29 1998-09-03 Access Pharmaceuticals, Inc. Metal-ion chelates with acidic saccharides and glycosaminoglycans

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DE3129906C3 (en) * 1981-07-24 1996-12-19 Schering Ag Paramagnetic complex salts, their preparation and agents for use in NMR diagnostics
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
NL194579C (en) * 1983-01-21 2002-08-05 Schering Ag Diagnostic.
DE3448606C2 (en) * 1983-01-21 2001-12-13 Schering Ag Diagnostic agents, processes for their production and their use
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SE8301395L (en) * 1983-03-15 1984-09-16 Wallac Oy KELATIZING COMPOUNDS WITH FUNCTIONAL GROUPS WHICH ALLOW COVALENT COUPLING TO BIO-ORGANIC MOLECULES
US4972837A (en) * 1983-04-26 1990-11-27 Regents Of The University Of California Contrast agents for nuclear magnetic resonance imaging
DE3316703A1 (en) * 1983-05-04 1984-11-08 Schering AG, 1000 Berlin und 4709 Bergkamen ORAL CONTRAST AGENT FOR MRI MRI AND THE PRODUCTION THEREOF
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AU566007B2 (en) 1987-10-08
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