NO164458C - PHYSIOLOGICALLY COMPATIBLE, PARAMAGNETIC COMPLEX SALTS AND AGENTS FOR USE IN NMR DIAGNOSTICS - Google Patents

PHYSIOLOGICALLY COMPATIBLE, PARAMAGNETIC COMPLEX SALTS AND AGENTS FOR USE IN NMR DIAGNOSTICS

Info

Publication number
NO164458C
NO164458C NO822546A NO822546A NO164458C NO 164458 C NO164458 C NO 164458C NO 822546 A NO822546 A NO 822546A NO 822546 A NO822546 A NO 822546A NO 164458 C NO164458 C NO 164458C
Authority
NO
Norway
Prior art keywords
agents
numbers
paramagnetic complex
nmr diagnostics
physiologically compatible
Prior art date
Application number
NO822546A
Other languages
Norwegian (no)
Other versions
NO164458B (en
NO822546L (en
Inventor
Heinz Gries
Douwe Rosenberg
Hans-Joachim Weinmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6137999&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO164458(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO822546L publication Critical patent/NO822546L/en
Publication of NO164458B publication Critical patent/NO164458B/en
Publication of NO164458C publication Critical patent/NO164458C/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281—Means for the use of in vitro contrast agents

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Signal Processing (AREA)
  • Optics & Photonics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. The use of at least one physiologically tolerable paramagnetic complex salt made from aminopolycarboxylic acids having the formulae I to IV see diagramm : EP0169299,P6,F1 N-hydroxyethyl-N,N',N'-ethylenediaminetriacetic acid (HEDTA), see diagramm : EP0169299,P6,F2 N,N,N',N",N"-diethylenetriaminepenta-acetic acid (DTPA), HOH2 C-CH2 N(CH2 COOH)2 N-hydroxyethylimino-diacetic acid, see diagramm : EP0169299,P6,F3 wherein m represents the numbers 1 to 4, n the numbers 0 to 2, R**1 a saturated or unsaturated hydrocarbon radical having from 4 to 12 hydrocarbon atoms or the group -CH2 -COOH, and from the ions of the lanthanide elements having the atomic numbers 57 to 70 or from the ions of the transition metals having the atomic numbers 21 to 29, 42 and 44 and, optionally from an inorganic base for the preparation of agents for NMR diagnostics.
NO822546A 1981-07-24 1982-07-23 PHYSIOLOGICALLY COMPATIBLE, PARAMAGNETIC COMPLEX SALTS AND AGENTS FOR USE IN NMR DIAGNOSTICS NO164458C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3129906A DE3129906C3 (en) 1981-07-24 1981-07-24 Paramagnetic complex salts, their preparation and agents for use in NMR diagnostics

Publications (3)

Publication Number Publication Date
NO822546L NO822546L (en) 1983-01-25
NO164458B NO164458B (en) 1990-07-02
NO164458C true NO164458C (en) 1992-11-23

Family

ID=6137999

Family Applications (2)

Application Number Title Priority Date Filing Date
NO822546A NO164458C (en) 1981-07-24 1982-07-23 PHYSIOLOGICALLY COMPATIBLE, PARAMAGNETIC COMPLEX SALTS AND AGENTS FOR USE IN NMR DIAGNOSTICS
NO1994031C NO1994031I1 (en) 1981-07-24 1994-12-30 The dimeglumine salt of gadopentetic acid / (di-N-methylglucamine salt of gadolinium (III) complex of diethylenetriaminepentaacetic acid

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1994031C NO1994031I1 (en) 1981-07-24 1994-12-30 The dimeglumine salt of gadopentetic acid / (di-N-methylglucamine salt of gadolinium (III) complex of diethylenetriaminepentaacetic acid

Country Status (12)

Country Link
EP (2) EP0169299B1 (en)
JP (3) JPS5829718A (en)
AT (2) ATE52247T1 (en)
AU (2) AU566007B2 (en)
CA (2) CA1218597A (en)
DE (3) DE3129906C3 (en)
IE (1) IE53639B1 (en)
LU (1) LU88291I2 (en)
NL (1) NL930072I2 (en)
NO (2) NO164458C (en)
NZ (1) NZ201372A (en)
ZA (1) ZA825313B (en)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
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JPH0339045B2 (en) 1991-06-12
DE3280157D1 (en) 1990-05-31
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NZ201372A (en) 1986-08-08
DE3129906C2 (en) 1990-05-17
LU88291I2 (en) 1994-05-04
AU8633082A (en) 1983-01-27
JPS5829718A (en) 1983-02-22
NO164458B (en) 1990-07-02
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EP0169299A3 (en) 1986-12-03
EP0169299A2 (en) 1986-01-29
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AU1018688A (en) 1988-04-28
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AU566007B2 (en) 1987-10-08
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ZA825313B (en) 1983-05-25
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JPH03209389A (en) 1991-09-12
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