ATE99538T1 - Mittel zur verwendung zum verlangsamen des haarausfalls sowie zum ausloesen und anregen ihres wachstums, die 2-alkyl-4-amino(bzw. 2,4dialkyl)pyrimidin-3-oxidderivate enthalten sowie neue 2-alkyl-4-aminopyrimidin-3-oxidderivate. - Google Patents

Mittel zur verwendung zum verlangsamen des haarausfalls sowie zum ausloesen und anregen ihres wachstums, die 2-alkyl-4-amino(bzw. 2,4dialkyl)pyrimidin-3-oxidderivate enthalten sowie neue 2-alkyl-4-aminopyrimidin-3-oxidderivate.

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Publication number
ATE99538T1
ATE99538T1 AT91401372T AT91401372T ATE99538T1 AT E99538 T1 ATE99538 T1 AT E99538T1 AT 91401372 T AT91401372 T AT 91401372T AT 91401372 T AT91401372 T AT 91401372T AT E99538 T1 ATE99538 T1 AT E99538T1
Authority
AT
Austria
Prior art keywords
alkyl
oxide derivatives
denotes
stimulating
growth
Prior art date
Application number
AT91401372T
Other languages
English (en)
Inventor
Didier Dufetel
Francoise Estradier
Michel Hocquaux
Original Assignee
Oreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oreal filed Critical Oreal
Application granted granted Critical
Publication of ATE99538T1 publication Critical patent/ATE99538T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT91401372T 1990-05-30 1991-05-29 Mittel zur verwendung zum verlangsamen des haarausfalls sowie zum ausloesen und anregen ihres wachstums, die 2-alkyl-4-amino(bzw. 2,4dialkyl)pyrimidin-3-oxidderivate enthalten sowie neue 2-alkyl-4-aminopyrimidin-3-oxidderivate. ATE99538T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9006693A FR2662607B1 (fr) 1990-05-30 1990-05-30 Composition destinee a etre utilisee pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives d'alkyl-2 amino-4 (ou dialkyl-2-4) pyrimidine oxyde-3 .
EP91401372A EP0459890B1 (de) 1990-05-30 1991-05-29 Mittel zur Verwendung zum Verlangsamen des Haarausfalls sowie zum Auslösen und Anregen ihres Wachstums, die 2-Alkyl-4-amino(bzw. 2,4-Dialkyl)pyrimidin-3-oxidderivate enthalten sowie neue 2-Alkyl-4-aminopyrimidin-3-oxidderivate

Publications (1)

Publication Number Publication Date
ATE99538T1 true ATE99538T1 (de) 1994-01-15

Family

ID=9397077

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91401372T ATE99538T1 (de) 1990-05-30 1991-05-29 Mittel zur verwendung zum verlangsamen des haarausfalls sowie zum ausloesen und anregen ihres wachstums, die 2-alkyl-4-amino(bzw. 2,4dialkyl)pyrimidin-3-oxidderivate enthalten sowie neue 2-alkyl-4-aminopyrimidin-3-oxidderivate.

Country Status (7)

Country Link
US (1) US5438058A (de)
EP (1) EP0459890B1 (de)
JP (1) JP3073047B2 (de)
AT (1) ATE99538T1 (de)
CA (1) CA2043573A1 (de)
DE (1) DE69100919T2 (de)
FR (1) FR2662607B1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2671082B1 (fr) * 1990-12-28 1993-04-16 Oreal Agent a plusieurs composants ou kit de preparation de la forme sulfo-conjuguee de composes pyrimidino- ou triazino-n-oxyde et procede de mise en óoeuvre.
US6203803B1 (en) 1994-12-14 2001-03-20 Societe L'oreal S.A. Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained
FR2728166A1 (fr) * 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2732597B1 (fr) * 1995-04-05 1997-05-16 Oreal Utilisation dans une composition en tant qu'activateur et/ou stabilisateur de cyclooxygenase d'au moins un derive de pyrimidine substitue en 6
FR2732598B1 (fr) 1995-04-10 1997-05-09 Oreal Utilisation de sel de metaux alcalino-terreux pour le traitement des prurits et des dysesthesies oculaires ou palpebraux
EP0737471A3 (de) * 1995-04-10 2000-12-06 L'oreal Verwendung von Erdalkalimetallsalze als TNF-alpha Inhibitor in einer topischen Zusammensetzung und die so hergestellte Zusammensetzung
FR2738741B1 (fr) * 1995-09-19 1997-12-05 Oreal Composition pour la teinture des fibres keratiniques, contenant un antagoniste de substance p
FR2740341B1 (fr) * 1995-10-26 1997-12-19 Oreal Utilisation de sel de lanthanide, d'etain, de zinc, de manganese, d'yttrium, de cobalt, de baryum, de strontium dans une composition pour la peau
US6159950A (en) * 1998-10-16 2000-12-12 Cornell Research Foundation, Inc. Method of modulating hair growth
FR2791671B1 (fr) 1999-04-01 2001-05-11 Oreal Nouveaux composes derives d'esters d'acide benzoique, composition les comprenant et utilisation
EP2260845A3 (de) 2002-06-21 2012-08-22 L'Oréal Verwendung von Polyphenolen zur Behandlung der Alopezie
US7326717B2 (en) 2003-05-06 2008-02-05 L'oreal Pyrimidine n-oxide compounds for stimulating the growth of keratin fibers and/or reducing loss thereof
FR2854630B1 (fr) * 2003-05-06 2005-06-10 Oreal Composition capilaire contenant un derive de pyrimidine n-oxydase, son utilisation pour stimuler la pousse des fibres keratiniques et/ou freiner leur chute
US20060193804A1 (en) * 2005-02-24 2006-08-31 L'oreal Haircare use of cyclic amine derivatives
FR2920309B1 (fr) 2007-08-28 2010-05-28 Galderma Res & Dev Utilisation de travoprost pour traiter la chute des cheveux
FR2949052B1 (fr) 2009-08-13 2015-03-27 Oreal Procede de traitement cosmetique du cuir chevelu.
FR2953722B1 (fr) 2009-12-16 2012-03-09 Expanscience Lab Composition comprenant au moins un sucre en c7 pour le traitement de l'alopecie, pour le traitement cosmetique des phaneres, et pour le soin des cheveux, cils ou ongles
CA2870666A1 (en) 2012-04-16 2013-10-24 Case Western Reserve University Compositions and methods of modulating 15-pgdh activity
CA2927730A1 (en) 2013-10-15 2015-05-07 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
WO2015085373A1 (en) 2013-12-12 2015-06-18 Cellmid Limited Method of treatment of alopecia with monoterpenoids
EP3226859B1 (de) 2014-12-05 2025-03-26 Case Western Reserve University Akr1a1-inhibitoren zur verwendung zur senkung des cholesterinspiegels und zur modulation der s-nitrosylierung
EP3548035A4 (de) 2016-11-30 2020-07-22 Case Western Reserve University Kombinationen von 15-pgdh-inhibitoren mit corticosteroiden und/oder tnf-inhibitoren und verwendungen davon
CN110573154A (zh) 2017-02-06 2019-12-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
WO2020106998A1 (en) 2018-11-21 2020-05-28 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
AU2021224268A1 (en) 2020-02-21 2022-09-15 Case Western Reserve University Compositions and methods for treating renal injury
EP3895685A1 (de) 2020-04-14 2021-10-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Natürliche zusammensetzung zur haarwachstumsstimulation und haarverlustverhinderung und behandlung ohne konservierungsmittel
EP3895686B1 (de) 2020-04-14 2025-04-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Natürliche zusammensetzung zur stimulierung des haarwuchses und zur vorbeugung und behandlung von haarausfall
CR20220654A (es) 2020-05-20 2023-08-24 Rodeo Therapeutics Corp Composiciones y métodos para modular la actividad de deshidrogenasas de cadena corta

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Publication number Priority date Publication date Assignee Title
US3551420A (en) * 1967-01-23 1970-12-29 Upjohn Co 1,2-dihydro - 1 - hydroxy-6-alkyl-2-(aminomethylimino)pyrimidines and 1,6 - dihydro-1-hydroxy - 2 - alkyl - 6-(aminomethylimino)pyrimidines
GB1143167A (en) * 1967-01-25 1969-02-19 Ucb Sa Derivatives of pyrimidine
US4139619A (en) * 1976-05-24 1979-02-13 The Upjohn Company 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth
DE2903133A1 (de) * 1979-01-27 1980-08-07 Bayer Ag Quartaere reaktivverbindungen
US4321484A (en) * 1979-02-28 1982-03-23 International Business Machines Corporation Field effect transistor multivibrator
WO1985004577A1 (en) * 1984-04-06 1985-10-24 Gail Sansone Bazzano Compositions used for hair growth
EP0210227B1 (de) * 1985-01-25 1990-05-02 The Upjohn Company Pyrimidinsulfate für haarwuchs
LU86695A1 (fr) * 1986-12-01 1988-07-14 Oreal Nouveaux derives de piperazinyl-1 pyrimidine,leur preparation et leur application en therapeutique et cosmetique
LU86959A1 (fr) * 1987-07-31 1989-03-08 Oreal Nouveaux derives d'ureylene triamino-2,4,6 pyrimidine oxyde-3,leur preparation et leur utilisation en cosmetique et dermopharmacie
LU87308A1 (fr) * 1988-08-01 1990-03-13 Oreal Nouveaux derives de diamino-2,4 pyrimidine oxyde-3 et leur utilisation pour le traitement et la prevention de la chute des cheveux
DE3905364A1 (de) * 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool

Also Published As

Publication number Publication date
CA2043573A1 (fr) 1991-12-01
JPH04235172A (ja) 1992-08-24
EP0459890A1 (de) 1991-12-04
US5438058A (en) 1995-08-01
FR2662607B1 (fr) 1992-08-28
EP0459890B1 (de) 1994-01-05
FR2662607A1 (fr) 1991-12-06
DE69100919T2 (de) 1994-05-05
DE69100919D1 (de) 1994-02-17
JP3073047B2 (ja) 2000-08-07

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