ATE96152T1 - 2-methylthiomethyl-dihydropyridine, verfahren zur herstellung und pharmazeutische zusammenstellungen, die sie enthalten. - Google Patents

2-methylthiomethyl-dihydropyridine, verfahren zur herstellung und pharmazeutische zusammenstellungen, die sie enthalten.

Info

Publication number
ATE96152T1
ATE96152T1 AT87118145T AT87118145T ATE96152T1 AT E96152 T1 ATE96152 T1 AT E96152T1 AT 87118145 T AT87118145 T AT 87118145T AT 87118145 T AT87118145 T AT 87118145T AT E96152 T1 ATE96152 T1 AT E96152T1
Authority
AT
Austria
Prior art keywords
aryl
alkoxycarbonyl
heteroaryl
substituted
methylthiomethyl
Prior art date
Application number
AT87118145T
Other languages
English (en)
Inventor
Marco Frigerio
Andrea Zaliani
Carlo Riva
Carmelo A Gandolfi
Odoardo Tofanetti
Sergio Tognella
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Application granted granted Critical
Publication of ATE96152T1 publication Critical patent/ATE96152T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT87118145T 1986-12-11 1987-12-08 2-methylthiomethyl-dihydropyridine, verfahren zur herstellung und pharmazeutische zusammenstellungen, die sie enthalten. ATE96152T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8622648A IT1213555B (it) 1986-12-11 1986-12-11 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono.
EP87118145A EP0271059B1 (de) 1986-12-11 1987-12-08 2-Methylthiomethyl-dihydropyridine, Verfahren zur Herstellung und pharmazeutische Zusammenstellungen, die sie enthalten

Publications (1)

Publication Number Publication Date
ATE96152T1 true ATE96152T1 (de) 1993-11-15

Family

ID=11198832

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87118145T ATE96152T1 (de) 1986-12-11 1987-12-08 2-methylthiomethyl-dihydropyridine, verfahren zur herstellung und pharmazeutische zusammenstellungen, die sie enthalten.

Country Status (10)

Country Link
US (1) US4971984A (de)
EP (1) EP0271059B1 (de)
JP (1) JPS63170360A (de)
KR (1) KR880007468A (de)
AT (1) ATE96152T1 (de)
AU (1) AU611872B2 (de)
DE (1) DE3787878D1 (de)
IT (1) IT1213555B (de)
PH (1) PH25966A (de)
ZA (1) ZA879301B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930011486B1 (ko) * 1985-08-06 1993-12-08 베링거 만하임 이탈리아 에스.피.에이. 제약상 유효한 2-티오메틸-치환-1,4-디히드로피리딘
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US6699892B2 (en) 2002-06-04 2004-03-02 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salt of amlodipine and method of preparing the same
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
EA024559B1 (ru) 2009-05-06 2016-09-30 Лаборэтори Скин Кэа, Инк. Композиции для нанесения на кератинизированную поверхность кожи млекопитающего и способ доставки
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
IL68604A0 (en) * 1982-05-21 1983-09-30 Haessle Ab Processes for preparing therapeutically active dihydropyridines and intermediates for the processes
US4515799A (en) * 1983-02-02 1985-05-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
GB8415386D0 (en) * 1984-06-15 1984-07-18 Pfizer Ltd Therapeutic agents
DE3426732A1 (de) * 1984-07-20 1986-01-23 Bayer Ag, 5090 Leverkusen Material fuer stuetzverbaende
IL78642A0 (en) * 1985-05-03 1986-08-31 Pfizer Dihydropyridines and pharmaceutical compositions containing them
FI862343A (fi) * 1985-06-17 1986-12-18 Warner Lambert Co Foerfarande foer framstaellning av terapeutiskt verkande 1,4-dihydropyridinfoereningar.
KR930011486B1 (ko) * 1985-08-06 1993-12-08 베링거 만하임 이탈리아 에스.피.에이. 제약상 유효한 2-티오메틸-치환-1,4-디히드로피리딘
IT1204421B (it) * 1986-06-27 1989-03-01 Boehringer Biochemia Srl 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono
GB8526411D0 (en) * 1985-10-25 1985-11-27 Pfizer Ltd Dihydropyridines
GB8527698D0 (en) * 1985-11-09 1985-12-11 Pfizer Ltd Dihydropyridine antiischaemic & antihypertensive agents
EP0225175A3 (de) * 1985-11-28 1988-12-28 FISONS plc Dihydropyridin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
AU8229487A (en) 1988-06-16
DE3787878D1 (de) 1993-11-25
ZA879301B (en) 1988-08-31
KR880007468A (ko) 1988-08-27
AU611872B2 (en) 1991-06-27
JPS63170360A (ja) 1988-07-14
US4971984A (en) 1990-11-20
EP0271059B1 (de) 1993-10-20
IT1213555B (it) 1989-12-20
IT8622648A0 (it) 1986-12-11
PH25966A (en) 1992-01-13
EP0271059A1 (de) 1988-06-15

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties