ATE944T1 - PROCESS FOR THE PRODUCTION OF BONE REPLACEMENT MATERIAL WITH IMPROVED BIOLOGICAL STABILITY BASED ON COLLAGEN AND THE OBTAINED BONE REPLACEMENT MATERIAL. - Google Patents
PROCESS FOR THE PRODUCTION OF BONE REPLACEMENT MATERIAL WITH IMPROVED BIOLOGICAL STABILITY BASED ON COLLAGEN AND THE OBTAINED BONE REPLACEMENT MATERIAL.Info
- Publication number
- ATE944T1 ATE944T1 AT79105190T AT79105190T ATE944T1 AT E944 T1 ATE944 T1 AT E944T1 AT 79105190 T AT79105190 T AT 79105190T AT 79105190 T AT79105190 T AT 79105190T AT E944 T1 ATE944 T1 AT E944T1
- Authority
- AT
- Austria
- Prior art keywords
- water
- replacement material
- bone replacement
- biological stability
- improved biological
- Prior art date
Links
- 239000000316 bone substitute Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 102000008186 Collagen Human genes 0.000 title 1
- 108010035532 Collagen Proteins 0.000 title 1
- 229920001436 collagen Polymers 0.000 title 1
- 239000000463 material Substances 0.000 abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 210000000988 bone and bone Anatomy 0.000 abstract 2
- 238000005238 degreasing Methods 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008139 complexing agent Substances 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000049 pigment Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
Abstract
1. A process for producing a bone substitute material having an improved biological stability by using animal or human bone material as the starting substance, which includes a) removing the blood pigment and other water-soluble proteins from the bone material by treatment with water ; subsequently b) removing water-insoluble proteins by treatment with H2 O2 solution ; then c) rinsing in cold water ; then d) degreasing with an organic solvent ; and e) sterilizing the material obtained by a conventional method, characterized in that f) the step of degreasing is carried out immediately after the step of rinsing in cold water which follows upon the removal of proteins, g) the mineral content is subsequently eliminated by dissolution with a complexing agent or an ion exchanger, and h) the material obtained is rinsed in running water in order to remove the residual salts therefrom.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2854490A DE2854490C2 (en) | 1978-12-16 | 1978-12-16 | Bone substitute material with improved biological stability based on collagen |
EP79105190A EP0012959B1 (en) | 1978-12-16 | 1979-12-14 | Method of preparation of collagen-based bone substitute material with improved biological stability and bone substitute material obtained by this method |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE944T1 true ATE944T1 (en) | 1982-05-15 |
Family
ID=6057451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT79105190T ATE944T1 (en) | 1978-12-16 | 1979-12-14 | PROCESS FOR THE PRODUCTION OF BONE REPLACEMENT MATERIAL WITH IMPROVED BIOLOGICAL STABILITY BASED ON COLLAGEN AND THE OBTAINED BONE REPLACEMENT MATERIAL. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0012959B1 (en) |
JP (1) | JPS5584161A (en) |
AT (1) | ATE944T1 (en) |
CA (1) | CA1142430A (en) |
DE (2) | DE2854490C2 (en) |
DK (1) | DK154892C (en) |
ES (1) | ES486893A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4430760A (en) * | 1981-12-18 | 1984-02-14 | Collagen Corporation | Nonstress-bearing implantable bone prosthesis |
DE3124981A1 (en) * | 1981-06-25 | 1983-01-13 | Dr. Ruhland Nachfolger GmbH, 8425 Neustadt | ACTIVE INGREDIENT COLLAGEN INSERT FOR INSERTION INTO BONES OR SOFT PARTS AND METHOD FOR THEIR PRODUCTION |
ATE31616T1 (en) * | 1983-10-20 | 1988-01-15 | Oscobal Ag | BONE REPLACEMENT MATERIAL BASED ON NATURAL BONES. |
JPS6162459A (en) * | 1984-07-06 | 1986-03-31 | コラ−ゲン コ−ポレイシヨン | Repairing of bone using collagen |
US4789663A (en) * | 1984-07-06 | 1988-12-06 | Collagen Corporation | Methods of bone repair using collagen |
US5522894A (en) * | 1984-12-14 | 1996-06-04 | Draenert; Klaus | Bone replacement material made of absorbable beads |
US5053049A (en) * | 1985-05-29 | 1991-10-01 | Baxter International | Flexible prostheses of predetermined shapes and process for making same |
US4678470A (en) * | 1985-05-29 | 1987-07-07 | American Hospital Supply Corporation | Bone-grafting material |
US4627853A (en) * | 1985-05-29 | 1986-12-09 | American Hospital Supply Corporation | Method of producing prostheses for replacement of articular cartilage and prostheses so produced |
AT398373B (en) * | 1987-12-17 | 1994-11-25 | Immuno Ag | BIOLOGICAL RESORBABLE IMPLANTATION MATERIAL AND METHOD FOR PRODUCING THE SAME |
US4975526A (en) * | 1989-02-23 | 1990-12-04 | Creative Biomolecules, Inc. | Bone collagen matrix for zenogenic implants |
DE3835237C1 (en) * | 1988-10-15 | 1989-12-28 | B. Braun Melsungen Ag, 3508 Melsungen, De | |
EP0424159A3 (en) * | 1989-10-19 | 1991-11-06 | Osteotech, Inc., | Aseptic processing of allograft bone and tissue |
US5531791A (en) * | 1993-07-23 | 1996-07-02 | Bioscience Consultants | Composition for repair of defects in osseous tissues, method of making, and prosthesis |
DE4425776C2 (en) * | 1994-07-13 | 2002-08-29 | Britta Hofmann | Process for the preparation of an improved collagen graft with a loosened structure |
IT1268641B1 (en) * | 1994-10-24 | 1997-03-06 | Giuseppe Oliva | INACTIVATION AND ELIMINATION OF ORGANIC MATRIX FROM ANIMAL BONE FOR HETEROTOPICAL XENOTOPLANTS. |
FR2752382B1 (en) * | 1996-08-16 | 1998-10-09 | Assist Publ Hopitaux De Paris | PROCESS FOR THE TREATMENT OF HUMAN OR ANIMAL PRODUCTS FOR THERAPEUTIC USE |
US5972368A (en) * | 1997-06-11 | 1999-10-26 | Sdgi Holdings, Inc. | Bone graft composites and spacers |
DE10157182A1 (en) * | 2001-11-22 | 2003-06-05 | Matricel Gmbh | Process for the treatment of materials of biological origin and elastin product |
AT413075B (en) * | 2003-02-25 | 2005-11-15 | Austria Wirtschaftsserv Gmbh | METHOD FOR PRODUCING A BONE IMPLANT MATERIAL AND DEVICE FOR CARRYING OUT THIS METHOD |
GB2431408A (en) * | 2005-10-19 | 2007-04-25 | Osta Technologies Cc | Bone material and a process for the preparation of bone material |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE961654C (en) * | 1954-06-16 | 1957-04-11 | Armin Bauermeister | Process for the preparation of bones suitable for transplantation |
GB1068587A (en) * | 1963-12-06 | 1967-05-10 | Biorex Laboratories Ltd | Dental fillers and bone cements comprising collagen |
SU498005A1 (en) * | 1971-08-13 | 1976-01-05 | Центральный научно-исследовательский институт стоматологии | Stimulating anti-inflammatory agent for treatment in dentistry |
-
1978
- 1978-12-16 DE DE2854490A patent/DE2854490C2/en not_active Expired
-
1979
- 1979-12-13 DK DK530279A patent/DK154892C/en active
- 1979-12-13 CA CA000341820A patent/CA1142430A/en not_active Expired
- 1979-12-14 EP EP79105190A patent/EP0012959B1/en not_active Expired
- 1979-12-14 ES ES486893A patent/ES486893A1/en not_active Expired
- 1979-12-14 AT AT79105190T patent/ATE944T1/en not_active IP Right Cessation
- 1979-12-14 DE DE7979105190T patent/DE2962750D1/en not_active Expired
- 1979-12-15 JP JP16344279A patent/JPS5584161A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS5584161A (en) | 1980-06-25 |
DK154892B (en) | 1989-01-02 |
CA1142430A (en) | 1983-03-08 |
DK154892C (en) | 1989-06-05 |
DE2962750D1 (en) | 1982-06-24 |
JPS619857B2 (en) | 1986-03-26 |
DK530279A (en) | 1980-06-17 |
DE2854490B1 (en) | 1980-06-12 |
EP0012959A1 (en) | 1980-07-09 |
EP0012959B1 (en) | 1982-05-05 |
DE2854490C2 (en) | 1981-04-09 |
ES486893A1 (en) | 1980-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEIH | Change in the person of patent owner | ||
EEFA | Change of the company name | ||
REN | Ceased due to non-payment of the annual fee |