ATE83486T1 - Verfahren zur herstellung von cephalosporinverbindungen. - Google Patents

Verfahren zur herstellung von cephalosporinverbindungen.

Info

Publication number
ATE83486T1
ATE83486T1 AT87102563T AT87102563T ATE83486T1 AT E83486 T1 ATE83486 T1 AT E83486T1 AT 87102563 T AT87102563 T AT 87102563T AT 87102563 T AT87102563 T AT 87102563T AT E83486 T1 ATE83486 T1 AT E83486T1
Authority
AT
Austria
Prior art keywords
sup
compound
stands
salt
formula
Prior art date
Application number
AT87102563T
Other languages
English (en)
Inventor
Kenzo Naito
Yukio Ishibashi
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE83486T1 publication Critical patent/ATE83486T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT87102563T 1986-02-28 1987-02-24 Verfahren zur herstellung von cephalosporinverbindungen. ATE83486T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4499286 1986-02-28
EP87102563A EP0234549B1 (de) 1986-02-28 1987-02-24 Verfahren zur Herstellung von Cephalosporinverbindungen

Publications (1)

Publication Number Publication Date
ATE83486T1 true ATE83486T1 (de) 1993-01-15

Family

ID=12706934

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87102563T ATE83486T1 (de) 1986-02-28 1987-02-24 Verfahren zur herstellung von cephalosporinverbindungen.

Country Status (10)

Country Link
US (1) US4980464A (de)
EP (1) EP0234549B1 (de)
JP (1) JPH082908B2 (de)
KR (1) KR930007808B1 (de)
CN (1) CN1024011C (de)
AT (1) ATE83486T1 (de)
CA (1) CA1293718C (de)
DE (1) DE3783048T2 (de)
ES (1) ES2052501T3 (de)
HU (1) HU198499B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587474A (en) * 1992-06-18 1996-12-24 Tanabe Seiyaku Co., Ltd. Method for removing the protecting group for carboxyl group
EP1635858A4 (de) * 2003-05-29 2009-08-26 Scripps Research Inst Gezielte abgabe an legumain exprimierende zellen
EP1976861A2 (de) * 2005-11-29 2008-10-08 The Scripps Research Institute Hemmung von tumorzellinvasion, metastasen und angiogenese durch targetting von legumin
US8198434B2 (en) 2008-05-07 2012-06-12 Idexx Laboratories, Inc. Process for preparing cefsulodin sodium
CN110950816B (zh) * 2019-12-13 2021-07-06 山东金城医药化工有限公司 1-(2-二甲基氨基乙基)-5-巯基四唑的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3276809D1 (en) * 1981-09-10 1987-08-27 Takeda Chemical Industries Ltd Method for production of cephalosporin compounds
EP0262744B1 (de) * 1986-10-02 1994-03-23 Asahi Kasei Kogyo Kabushiki Kaisha Verfahren zur Herstellung von 3-Alkoxymethylcephalosporinen

Also Published As

Publication number Publication date
DE3783048D1 (de) 1993-01-28
CN87101581A (zh) 1987-09-30
JPH082908B2 (ja) 1996-01-17
ES2052501T3 (es) 1994-07-16
JPS62277389A (ja) 1987-12-02
US4980464A (en) 1990-12-25
EP0234549A3 (en) 1989-05-31
EP0234549B1 (de) 1992-12-16
KR930007808B1 (ko) 1993-08-20
HU198499B (en) 1989-10-30
EP0234549A2 (de) 1987-09-02
CA1293718C (en) 1991-12-31
HUT44560A (en) 1988-03-28
CN1024011C (zh) 1994-03-16
DE3783048T2 (de) 1993-04-15
KR870007938A (ko) 1987-09-23

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Legal Events

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