ATE70450T1 - Zusammensetzungen aus vanadium und peroxyd als nachahmungsmittel von insulin. - Google Patents
Zusammensetzungen aus vanadium und peroxyd als nachahmungsmittel von insulin.Info
- Publication number
- ATE70450T1 ATE70450T1 AT87309106T AT87309106T ATE70450T1 AT E70450 T1 ATE70450 T1 AT E70450T1 AT 87309106 T AT87309106 T AT 87309106T AT 87309106 T AT87309106 T AT 87309106T AT E70450 T1 ATE70450 T1 AT E70450T1
- Authority
- AT
- Austria
- Prior art keywords
- peroxide
- insulin
- mimicagents
- vanadium
- compositions
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000004877 Insulin Human genes 0.000 title abstract 2
- 108090001061 Insulin Proteins 0.000 title abstract 2
- 229940125396 insulin Drugs 0.000 title abstract 2
- 150000002978 peroxides Chemical class 0.000 title abstract 2
- 229910052720 vanadium Inorganic materials 0.000 title 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical group [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000003190 augmentative effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
- LSGOVYNHVSXFFJ-UHFFFAOYSA-N vanadate(3-) Chemical compound [O-][V]([O-])([O-])=O LSGOVYNHVSXFFJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000520627A CA1277599C (en) | 1986-10-16 | 1986-10-16 | Vanadium - peroxide compositions as insulin mimickers |
| EP87309106A EP0264278B1 (de) | 1986-10-16 | 1987-10-15 | Zusammensetzungen aus Vanadium und Peroxyd als Nachahmungsmittel von Insulin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE70450T1 true ATE70450T1 (de) | 1992-01-15 |
Family
ID=4134156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87309106T ATE70450T1 (de) | 1986-10-16 | 1987-10-15 | Zusammensetzungen aus vanadium und peroxyd als nachahmungsmittel von insulin. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US4882171A (de) |
| EP (1) | EP0264278B1 (de) |
| JP (1) | JPS63179828A (de) |
| AT (1) | ATE70450T1 (de) |
| AU (1) | AU602927B2 (de) |
| CA (1) | CA1277599C (de) |
| DE (1) | DE3775331D1 (de) |
| GR (1) | GR3003402T3 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155031A (en) * | 1990-06-07 | 1992-10-13 | Posner Barry I | Use of pervanadate as an inhibitor of phosphotyrosine phosphatase |
| US5300496A (en) * | 1991-09-30 | 1994-04-05 | The University Of British Columbia | Complexed vanadium for the treatment of diabetes mellitus |
| US5866563A (en) * | 1991-09-30 | 1999-02-02 | The University Of British Columbia | Vanadium compositions |
| US5527790A (en) * | 1991-09-30 | 1996-06-18 | The University Of British Columbia | Bis(maltolato)oxovanadium compositions for the treatment of elevated blood sugar |
| IL99666A (en) * | 1991-10-07 | 1996-09-12 | Yeda Res & Dev | Vanadyl complexes of hydroxamate chelators and pharmaceutical compositions comprising them |
| FR2686514B1 (fr) * | 1992-01-28 | 1994-05-20 | Ir2M | Composition pharmaceutique contenant comme principe actif des associations de vanadium et/ou de niobium avec des composes organiques contenant un cycle renfermant au moins deux atomes d'azote. |
| FR2686603B1 (fr) * | 1992-01-28 | 1995-07-13 | Ir2M | Complexes organometalliques du niobium ou du vanadium avec des derives de l'acide dithiocarbamique et de ses sels et composition pharmaceutique contenant ces complexes ou leurs constituants. |
| FR2686511B1 (fr) * | 1992-01-28 | 1995-06-23 | Ir2M | Composition pharmaceutique contenant des associations de vanadium et/ou de niobium avec des acides amines ou des derives d'acides amines. |
| WO1993014772A1 (fr) * | 1992-01-28 | 1993-08-05 | I. R. 2. M. | Utilisation des derives du niobium comme principe actif de medicaments utiles dans le traitement et/ou la prevention des desordres du metabolisme des glucides et/ou des lipides |
| FR2686512B1 (fr) * | 1992-01-28 | 1995-06-30 | Ir2M | Compositions pharmaceutiques contenant comme principe actif des associations de vanadium et/ou de niobium avec des derives du pyrocatechol. |
| US5401640A (en) * | 1992-03-30 | 1995-03-28 | Trustees Of Dartmouth College | Method for enhancing detection of superoxide anion |
| FR2704035B1 (fr) * | 1993-04-15 | 1995-06-09 | Alliedsignal Europ Services | Ensemble d'un element de friction equipe d'un ressort pour frein a disque. |
| US5422125A (en) * | 1993-07-12 | 1995-06-06 | Baker Norton Pharmaceuticals, Inc. | Method and composition for treatment of insulin resistance syndromes |
| US5871779A (en) * | 1994-01-18 | 1999-02-16 | Mount Sinai Hospital Corporation | Treatment of arthropathies with vanadate compounds or analogues thereof |
| US5843481A (en) * | 1994-01-18 | 1998-12-01 | Mount Sinai Hospital Corporation | Treatment of proliferative disorders, metastasaes, and drug resistant tumors with vanadate compounds and derivatives or analogues thereof |
| US5595763A (en) * | 1995-07-19 | 1997-01-21 | Quimica Farmaceutica Bayer S.A. | Tungsten (VI) compositions for the oral treatment of diabetes mellitus |
| GB9525703D0 (en) * | 1995-12-15 | 1996-02-14 | Ciba Geigy Ag | Screening method |
| US5962030A (en) * | 1997-03-07 | 1999-10-05 | Akesis Pharmaceuticals, Inc. | Dietary supplement and method of treatment for diabetic control |
| EP1113804A2 (de) | 1998-09-17 | 2001-07-11 | Akesis Pharmaceuticals, Inc. | Kombinationen des chroms oder des vanadiums mit antidiabetika für glukosemetabolismusstörungen |
| US6376549B1 (en) * | 1998-09-17 | 2002-04-23 | Akesis Pharmaceuticals, Inc. | Metforimin-containing compositions for the treatment of diabetes |
| US20030055106A1 (en) * | 1999-08-12 | 2003-03-20 | Robert Faure | Therapeutic uses of peroxometallic compounds |
| ES2168084B1 (es) * | 2000-11-07 | 2003-11-16 | Univ Barcelona | Combinacion de aminas y compuestos de vanadio (iv) (v) para el tratatamiento y/o la prevencion de la diabetes mellitus. |
| PL231079B1 (pl) | 2012-11-07 | 2019-01-31 | Univ Jagiellonski | Kompleksy wanadu z hydrazydohydrazonami, preparaty farmaceutyczne oraz zastosowanie kompleksów wanadu z hydrazydohydrazonami |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2653537C3 (de) * | 1976-11-25 | 1979-08-23 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren und Mittel zur Bestimmung von Hydroperoxiden |
| DE2856487A1 (de) * | 1977-12-29 | 1979-07-12 | Wako Pure Chem Ind Ltd | Verfahren zur bestimmung von peroxidischen substanzen und hierfuer brauchbare verbindungen |
| US4343794A (en) * | 1980-05-06 | 1982-08-10 | Mt. Sinai | Method of reducing intraocular pressure with salts of vanadic acid |
| US4361487A (en) * | 1981-02-09 | 1982-11-30 | Fmc Corporation | Control of hydrogen sulfide emission from geothermal steam plants with hydrogen peroxide and sodium vanadate |
-
1986
- 1986-10-16 CA CA000520627A patent/CA1277599C/en not_active Expired - Lifetime
-
1987
- 1987-10-07 US US07/105,212 patent/US4882171A/en not_active Expired - Lifetime
- 1987-10-15 EP EP87309106A patent/EP0264278B1/de not_active Expired - Lifetime
- 1987-10-15 AU AU79793/87A patent/AU602927B2/en not_active Ceased
- 1987-10-15 DE DE8787309106T patent/DE3775331D1/de not_active Expired - Lifetime
- 1987-10-15 JP JP62258476A patent/JPS63179828A/ja active Pending
- 1987-10-15 AT AT87309106T patent/ATE70450T1/de not_active IP Right Cessation
-
1989
- 1989-09-12 US US07/406,253 patent/US5069913A/en not_active Expired - Fee Related
-
1991
- 1991-12-19 GR GR91401986T patent/GR3003402T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3775331D1 (de) | 1992-01-30 |
| JPS63179828A (ja) | 1988-07-23 |
| EP0264278A1 (de) | 1988-04-20 |
| AU602927B2 (en) | 1990-11-01 |
| AU7979387A (en) | 1988-04-21 |
| GR3003402T3 (en) | 1993-02-17 |
| EP0264278B1 (de) | 1991-12-18 |
| CA1277599C (en) | 1990-12-11 |
| US4882171A (en) | 1989-11-21 |
| US5069913A (en) | 1991-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |