ATE67853T1 - Biologische nachweisvorrichtung. - Google Patents

Biologische nachweisvorrichtung.

Info

Publication number
ATE67853T1
ATE67853T1 AT89300544T AT89300544T ATE67853T1 AT E67853 T1 ATE67853 T1 AT E67853T1 AT 89300544 T AT89300544 T AT 89300544T AT 89300544 T AT89300544 T AT 89300544T AT E67853 T1 ATE67853 T1 AT E67853T1
Authority
AT
Austria
Prior art keywords
layer
refractive index
plasmon resonance
fibre optic
surface plasmon
Prior art date
Application number
AT89300544T
Other languages
English (en)
Inventor
Martin Francis Finlan
Richard Paul Harvey
Original Assignee
Amersham Int Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Int Plc filed Critical Amersham Int Plc
Application granted granted Critical
Publication of ATE67853T1 publication Critical patent/ATE67853T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Electrotherapy Devices (AREA)
AT89300544T 1988-01-27 1989-01-20 Biologische nachweisvorrichtung. ATE67853T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888801807A GB8801807D0 (en) 1988-01-27 1988-01-27 Biological sensors
EP89300544A EP0326291B1 (de) 1988-01-27 1989-01-20 Biologische Nachweisvorrichtung

Publications (1)

Publication Number Publication Date
ATE67853T1 true ATE67853T1 (de) 1991-10-15

Family

ID=10630614

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89300544T ATE67853T1 (de) 1988-01-27 1989-01-20 Biologische nachweisvorrichtung.

Country Status (9)

Country Link
US (1) US5047213A (de)
EP (1) EP0326291B1 (de)
JP (1) JPH01224647A (de)
AT (1) ATE67853T1 (de)
AU (1) AU610975B2 (de)
CA (1) CA1336650C (de)
DE (1) DE68900277D1 (de)
GB (1) GB8801807D0 (de)
WO (1) WO1989007252A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4929049A (en) * 1988-01-29 1990-05-29 Fiberchem, Inc. Fiber optic refractive index sensor using a metal clad
DE3909143A1 (de) * 1989-03-21 1990-09-27 Basf Ag Verfahren zur untersuchung von oberflaechenstrukturen
AU6354190A (en) * 1989-08-21 1991-04-03 Board Of Regents Of The University Of Washington, The Multiple-probe diagnostic sensor
GB9015683D0 (en) * 1990-07-17 1990-09-05 Amersham Int Plc Testing for metal ions
CH684132A5 (fr) * 1990-10-16 1994-07-15 Suisse Electronique Microtech Dispositif optique à onde évanescente et son utilisation.
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
SE9201984D0 (sv) * 1992-06-29 1992-06-29 Pharmacia Biosensor Ab Improvement in optical assays
US5359681A (en) * 1993-01-11 1994-10-25 University Of Washington Fiber optic sensor and methods and apparatus relating thereto
US5327225A (en) * 1993-01-28 1994-07-05 The Center For Innovative Technology Surface plasmon resonance sensor
DE4305830C1 (de) * 1993-02-26 1994-08-18 Claus Dr Rer Nat Renschen SPR-Sensor
US5395587A (en) * 1993-07-06 1995-03-07 Smithkline Beecham Corporation Surface plasmon resonance detector having collector for eluted ligate
GB9320305D0 (en) * 1993-10-01 1993-11-17 Kodak Ltd Production of carriers for surface plasmin resonance
US5955153A (en) * 1993-10-01 1999-09-21 Johnson & Johnson Clinical Diagnostics, Inc. Production of carriers for surface plasmon resonance
GB9320310D0 (en) * 1993-10-01 1993-11-17 Kodak Ltd Production of carriers for surface plasmon resonance
DE4424628B4 (de) * 1994-07-13 2005-11-17 Lau, Matthias, Dipl.-Ing. Verfahren und Anordnung zur Brechzahlmessung verschiedener Medien
JPH0933427A (ja) * 1994-12-16 1997-02-07 Toto Ltd バイオセンサとこれを用いた濃度測定装置
US5591407A (en) * 1995-04-21 1997-01-07 American Research Corporation Of Virginia Laser diode sensor
US5606633A (en) * 1995-06-26 1997-02-25 American Research Corporation Of Virginia Chemical detector employing surface plasmon resonance excited using an optical waveguide configured as an asymmetric waveguide coupler
WO1997015820A1 (en) * 1995-10-25 1997-05-01 University Of Washington Surface plasmon resonance electrode as chemical sensor
DE19611025A1 (de) * 1996-03-20 1997-09-25 Inst Chemo Biosensorik Optischer Lichtwellenleitersensor auf der Basis der resonanten optischen Anregung von Oberflächenplasmawellen
JPH09292334A (ja) * 1996-04-30 1997-11-11 Fuji Photo Film Co Ltd 表面プラズモンセンサー
US5846843A (en) * 1996-11-18 1998-12-08 The University Of Toledo Sensor using long range surface plasmon resonance with diffraction double-grating
JPH10221249A (ja) * 1996-12-05 1998-08-21 Norio Miura 薬物の測定装置とセンサ及び該センサに用いる検出素子
US5864641A (en) * 1997-04-11 1999-01-26 F&S, Inc. Optical fiber long period sensor having a reactive coating
RU2141645C1 (ru) 1997-06-11 1999-11-20 Никитин Петр Иванович Способ исследования биологических, биохимических, химических характеристик сред и устройство для его осуществления
DE59811600D1 (de) * 1997-09-10 2004-07-29 Artificial Sensing Instr Asi A Optischer sensor und optisches verfahren zur charakterisierung einer chemischen und/oder biochemischen substanz
RU2141644C1 (ru) * 1997-12-18 1999-11-20 Коротков Константин Георгиевич Способ определения энергоинформационного воздействия тестируемого объекта на вещество в жидкой фазе
WO1999039190A1 (en) 1998-02-02 1999-08-05 Signature Bioscience Inc. Method and apparatus for detecting molecular binding events
US6395480B1 (en) 1999-02-01 2002-05-28 Signature Bioscience, Inc. Computer program and database structure for detecting molecular binding events
US6338968B1 (en) 1998-02-02 2002-01-15 Signature Bioscience, Inc. Method and apparatus for detecting molecular binding events
US6277651B1 (en) 1998-07-09 2001-08-21 Calspan Srl Corporation Diode laser electrochemical sensor for detecting chemical and biological analytes
GB9820919D0 (en) * 1998-09-26 1998-11-18 Secr Defence Diagnostic method
US6480282B1 (en) 1999-05-06 2002-11-12 University Of Washington Capillary surface plasmon resonance sensors and multisensors
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
US7198939B2 (en) * 2000-01-28 2007-04-03 Agilent Technologies, Inc. Apparatus for interrogating an addressable array
DE10006083B4 (de) 2000-02-11 2004-01-22 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Verfahren zur quantitativen und/oder qualitativen Bestimmung von Schichtdicken sowie ein Mikroreaktionsgefäß und eine Titerplatte
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
JP2002022654A (ja) * 2000-07-11 2002-01-23 Suzuki Motor Corp Ｓｐｒセンサプレート及びこれを用いた免疫反応測定装置
US7023544B2 (en) 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7264973B2 (en) 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7142296B2 (en) 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US7306827B2 (en) 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US7202076B2 (en) 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7101660B2 (en) 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7070987B2 (en) 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7217574B2 (en) 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US6951715B2 (en) 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7175980B2 (en) 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US7153702B2 (en) 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7118710B2 (en) 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US20020086430A1 (en) * 2000-12-28 2002-07-04 Hopmeier Michael J. Detection technology in agriculture operations
WO2002055993A2 (en) * 2001-01-12 2002-07-18 Univ Boston Use of electrostatic fields to enhance surface plasmon resonance spectroscopy
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US6562625B2 (en) 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
US20030077817A1 (en) * 2001-04-10 2003-04-24 Zarur Andrey J. Microfermentor device and cell based screening method
DE10126152C2 (de) * 2001-05-30 2003-12-24 Inst Mikrotechnik Mainz Gmbh Ortsaufgelöstes Ellipsometrie-Verfahren zur quantitativen und/oder qualitativen Bestimmung von Probenänderungen, Biochip und Meßanordnung
US6697667B1 (en) 2001-05-31 2004-02-24 Advanced Cardiovascular Systems, Inc. Apparatus and method for locating coronary sinus
US6716178B1 (en) 2001-05-31 2004-04-06 Advanced Cardiovascular Systems, Inc. Apparatus and method for performing thermal and laser doppler velocimetry measurements
US7532920B1 (en) 2001-05-31 2009-05-12 Advanced Cardiovascular Systems, Inc. Guidewire with optical fiber
US7329223B1 (en) * 2001-05-31 2008-02-12 Abbott Cardiovascular Systems Inc. Catheter with optical fiber sensor
US7300798B2 (en) * 2001-10-18 2007-11-27 Agilent Technologies, Inc. Chemical arrays
US6791690B2 (en) * 2002-04-30 2004-09-14 Agilent Technologies, Inc. Reading dry chemical arrays
US20040009516A1 (en) * 2002-05-08 2004-01-15 Nelson Bryce P. Arrayed SPR prism
ATE434175T1 (de) 2002-12-25 2009-07-15 Bio Rad Laboratories Oberflächenplasmonenresonanzsensor
JP2008505325A (ja) * 2004-07-08 2008-02-21 スウィンバーン ユニバーシティ オブ テクノロジー ファイバーセンサー製造
JP4371954B2 (ja) * 2004-08-31 2009-11-25 富士フイルム株式会社 表面プラズモン共鳴分析による被験物質の解析方法
US20060227328A1 (en) * 2005-04-08 2006-10-12 Vanwiggeren Gregory D Light-sensing system that uses light guides
US7648844B2 (en) 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7749445B2 (en) 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
WO2006130035A1 (fr) * 2005-06-01 2006-12-07 Sergey Valentinovich Koltsov Procede pour corriger le champ magnetique externe agissant sur un organisme vivant et procede de sa fabrication
US8509582B2 (en) * 2005-08-30 2013-08-13 Rambus Delaware Llc Reducing light leakage and improving contrast ratio performance in FTIR display devices
US20080129980A1 (en) * 2006-11-30 2008-06-05 North Carolina State University In-line fiber optic sensor devices and methods of fabricating same
US8354280B2 (en) 2007-09-06 2013-01-15 Bioscale, Inc. Reusable detection surfaces and methods of using same
US11009611B2 (en) 2019-06-18 2021-05-18 Eagle Technology, Llc Radiation detection system with surface plasmon resonance detection and related methods
US11085878B2 (en) * 2019-06-18 2021-08-10 Eagle Technology, Llc Radiation detection system with surface plasmon resonance detection and related methods

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE33064E (en) * 1981-09-18 1989-09-19 Prutec Limited Method for the determination of species in solution with an optical wave-guide
AU570425B2 (en) * 1982-12-21 1988-03-17 Applied Research Systems Ars Holding N.V. Assay technique
US4978503A (en) * 1984-06-13 1990-12-18 Ares-Serono Research & Development Limited Partnership Devices for use in chemical test procedures
US4775637A (en) * 1984-12-10 1988-10-04 Purtec Limited An immunoassay apparatus having at least two waveguides and method for its use
GB8509492D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optical assay
GB8509491D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optic waveguide biosensors
GB2185308B (en) * 1986-01-10 1989-10-25 Stc Plc Optical sensor device
JPS62220834A (ja) * 1986-03-24 1987-09-29 Toshiba Corp 光分析装置
JPS62254040A (ja) * 1986-04-16 1987-11-05 Daikin Ind Ltd 免疫検査装置
GB8705650D0 (en) * 1987-03-10 1987-04-15 Pa Consulting Services Assay technique
AT391160B (de) 1987-04-02 1990-08-27 Sgp Verkehrstechnik Tuerverriegelung fuer fahrzeuge, insbesondere fuer waggons mit schwenkschiebetueren
CA1321488C (en) * 1987-08-22 1993-08-24 Martin Francis Finlan Biological sensors
US4909990A (en) * 1987-09-02 1990-03-20 Myron J. Block Immunoassay apparatus
EP0341928A1 (de) * 1988-05-10 1989-11-15 AMERSHAM INTERNATIONAL plc Oberflächen-Resonanzplasmawellen-Sensoren

Also Published As

Publication number Publication date
AU2884289A (en) 1989-07-27
AU610975B2 (en) 1991-05-30
DE68900277D1 (de) 1991-10-31
US5047213A (en) 1991-09-10
WO1989007252A1 (en) 1989-08-10
EP0326291B1 (de) 1991-09-25
GB8801807D0 (en) 1988-02-24
EP0326291A1 (de) 1989-08-02
JPH01224647A (ja) 1989-09-07
CA1336650C (en) 1995-08-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee