ATE6738T1 - Ophthalmische praeparate, die kombinationen von carboanhydrase-inhibitoren und s-(-)-1-(tertbutylamino)-3-(4-morpholino-1,2,5-thiadiazol-3yl)-oxy-2-propanol enthalten fuer topische anwendung bei der behandlung intraokularer hypertension. - Google Patents

Ophthalmische praeparate, die kombinationen von carboanhydrase-inhibitoren und s-(-)-1-(tertbutylamino)-3-(4-morpholino-1,2,5-thiadiazol-3yl)-oxy-2-propanol enthalten fuer topische anwendung bei der behandlung intraokularer hypertension.

Info

Publication number
ATE6738T1
ATE6738T1 AT80400154T AT80400154T ATE6738T1 AT E6738 T1 ATE6738 T1 AT E6738T1 AT 80400154 T AT80400154 T AT 80400154T AT 80400154 T AT80400154 T AT 80400154T AT E6738 T1 ATE6738 T1 AT E6738T1
Authority
AT
Austria
Prior art keywords
morpholino
oxy
propanol
treatment
tertbutylamino
Prior art date
Application number
AT80400154T
Other languages
German (de)
English (en)
Inventor
Robert L. Smith
Ralph F. Hirschmann
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Application granted granted Critical
Publication of ATE6738T1 publication Critical patent/ATE6738T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT80400154T 1979-02-02 1980-01-31 Ophthalmische praeparate, die kombinationen von carboanhydrase-inhibitoren und s-(-)-1-(tertbutylamino)-3-(4-morpholino-1,2,5-thiadiazol-3yl)-oxy-2-propanol enthalten fuer topische anwendung bei der behandlung intraokularer hypertension. ATE6738T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US890379A 1979-02-02 1979-02-02
EP80400154A EP0014642B1 (en) 1979-02-02 1980-01-31 Ophthalmic compositions comprising combinations of carbonic anhydrase inhibitors and s-(-)-1-(tert-butylamino)-3-(4-morpholino-1,2,5-thiadiazol-3-yl)-oxy-2-propanol for topical application in the treatment of elevated intraocular pressure

Publications (1)

Publication Number Publication Date
ATE6738T1 true ATE6738T1 (de) 1984-04-15

Family

ID=21734364

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80400154T ATE6738T1 (de) 1979-02-02 1980-01-31 Ophthalmische praeparate, die kombinationen von carboanhydrase-inhibitoren und s-(-)-1-(tertbutylamino)-3-(4-morpholino-1,2,5-thiadiazol-3yl)-oxy-2-propanol enthalten fuer topische anwendung bei der behandlung intraokularer hypertension.

Country Status (9)

Country Link
EP (1) EP0014642B1 (enExample)
JP (1) JPS55122716A (enExample)
AT (1) ATE6738T1 (enExample)
AU (1) AU536438B2 (enExample)
DE (1) DE3067081D1 (enExample)
DK (1) DK43280A (enExample)
FI (1) FI800205A7 (enExample)
IE (1) IE49507B1 (enExample)
NZ (1) NZ192673A (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50901B1 (en) * 1980-03-04 1986-08-06 Merck & Co Inc Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure
GB8822285D0 (en) * 1988-09-22 1988-10-26 Ddsa Pharmaceuticals Ltd Opthalmic preparations
EP1507513A1 (de) * 2002-05-24 2005-02-23 Dr. GERHARD MANN chem.-pharm. Fabrik GmbH Tropfbares ophthalmisches gelpräparat mit diclofenamid und timolol
EP2847175A4 (en) * 2012-05-08 2016-04-20 Cellix Bio Private Ltd COMPOSITIONS AND METHODS INHIBITING THE ACTIVITY OF CARBONIC ANHYDRASE
KR101698163B1 (ko) * 2014-12-19 2017-01-19 동아에스티 주식회사 복령피 추출물을 함유하는 퇴행성 신경질환의 예방, 개선 또는 치료용 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860371A (en) * 1958-07-03 1961-02-01 Pfizer & Co C Di-sulfonamides and compositions containing them
NL7508856A (nl) * 1974-08-16 1976-02-18 Merck & Co Inc Werkwijze voor het bereiden van preparaten tegen hypertensie.
NZ182022A (en) * 1975-09-26 1978-12-18 Merck & Co Inc Antiglaucoma compositions comprising 1-t butylamino-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy)-2-prodanol hydogen maleate
US4077407A (en) * 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls

Also Published As

Publication number Publication date
IE800207L (en) 1980-08-02
DK43280A (da) 1980-08-03
EP0014642A2 (en) 1980-08-20
AU5487980A (en) 1980-08-07
AU536438B2 (en) 1984-05-10
IE49507B1 (en) 1985-10-16
NZ192673A (en) 1984-07-06
EP0014642A3 (en) 1981-01-07
EP0014642B1 (en) 1984-03-21
DE3067081D1 (en) 1984-04-26
FI800205A7 (fi) 1981-01-01
JPS55122716A (enExample) 1980-09-20

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee