ATE66152T1 - Reaktionsverbindung von 9-(2-hydroxyethoxymethyl)-guanin mit lactosaminiertem menschlichem albumin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate. - Google Patents
Reaktionsverbindung von 9-(2-hydroxyethoxymethyl)-guanin mit lactosaminiertem menschlichem albumin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.Info
- Publication number
- ATE66152T1 ATE66152T1 AT86114557T AT86114557T ATE66152T1 AT E66152 T1 ATE66152 T1 AT E66152T1 AT 86114557 T AT86114557 T AT 86114557T AT 86114557 T AT86114557 T AT 86114557T AT E66152 T1 ATE66152 T1 AT E66152T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxyethoxymethyl
- guanine
- human albumin
- preparation
- lactosamined
- Prior art date
Links
- 102000008100 Human Serum Albumin Human genes 0.000 title abstract 3
- 108091006905 Human Serum Albumin Proteins 0.000 title abstract 3
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 239000007864 aqueous solution Substances 0.000 abstract 2
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 150000004712 monophosphates Chemical class 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8522559A IT1207507B (it) | 1985-10-21 | 1985-10-21 | Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono. |
| EP86114557A EP0220657B1 (de) | 1985-10-21 | 1986-10-21 | Reaktionsverbindung von 9-(2-Hydroxyethoxymethyl)-guanin mit lactosaminiertem menschlichem Albumin, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE66152T1 true ATE66152T1 (de) | 1991-08-15 |
Family
ID=11197826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86114557T ATE66152T1 (de) | 1985-10-21 | 1986-10-21 | Reaktionsverbindung von 9-(2-hydroxyethoxymethyl)-guanin mit lactosaminiertem menschlichem albumin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4725672A (de) |
| EP (1) | EP0220657B1 (de) |
| AT (1) | ATE66152T1 (de) |
| DE (1) | DE3680857D1 (de) |
| ES (1) | ES2037654T3 (de) |
| IT (1) | IT1207507B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1245217B (it) * | 1991-03-12 | 1994-09-13 | Baldacci Lab Spa | Coniugato di azidotimidina ed albumina umana procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono |
| IT1256110B (it) * | 1992-11-23 | 1995-11-28 | Procedimento di coniugazione di nucleosidi antivirali con albumina umana lattosaminata | |
| ITMI20010027A1 (it) * | 2001-01-10 | 2002-07-10 | Uni Di Bologna Dipartimento Di | Composizioni teraputiche per una chemioterapia locoregionale non invasiva delle micrometastasi epatiche |
| US20140271772A1 (en) * | 2013-03-15 | 2014-09-18 | Barry J. Margulies | Biodegradable subcutaneous implants and methods of making |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1523865A (en) * | 1974-09-02 | 1978-09-06 | Wellcome Found | Purine compunds and salts thereof |
| IT1177381B (it) * | 1984-12-11 | 1987-08-26 | Baldacci Lab Spa | Metodo per la preparazione di coniugati della adenina-9-beta-d-arabino furano-side 5' monofosfato con albumina umana lattosaminata, coniugati risultanti e relative composizioi terapeuticamente attive |
-
1985
- 1985-10-21 IT IT8522559A patent/IT1207507B/it active
-
1986
- 1986-10-21 DE DE8686114557T patent/DE3680857D1/de not_active Expired - Fee Related
- 1986-10-21 ES ES198686114557T patent/ES2037654T3/es not_active Expired - Lifetime
- 1986-10-21 EP EP86114557A patent/EP0220657B1/de not_active Expired - Lifetime
- 1986-10-21 AT AT86114557T patent/ATE66152T1/de active
- 1986-10-21 US US06/921,209 patent/US4725672A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0220657A2 (de) | 1987-05-06 |
| IT1207507B (it) | 1989-05-25 |
| US4725672A (en) | 1988-02-16 |
| DE3680857D1 (de) | 1991-09-19 |
| EP0220657A3 (en) | 1988-10-05 |
| ES2037654T3 (es) | 1993-07-01 |
| IT8522559A0 (it) | 1985-10-21 |
| EP0220657B1 (de) | 1991-08-14 |
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