IT1256110B - Procedimento di coniugazione di nucleosidi antivirali con albumina umana lattosaminata - Google Patents
Procedimento di coniugazione di nucleosidi antivirali con albumina umana lattosaminataInfo
- Publication number
- IT1256110B IT1256110B ITMI922673A ITMI922673A IT1256110B IT 1256110 B IT1256110 B IT 1256110B IT MI922673 A ITMI922673 A IT MI922673A IT MI922673 A ITMI922673 A IT MI922673A IT 1256110 B IT1256110 B IT 1256110B
- Authority
- IT
- Italy
- Prior art keywords
- human albumin
- conjugation procedure
- antiviral nucleosides
- lactosaminated human
- lactosaminated
- Prior art date
Links
- 230000021615 conjugation Effects 0.000 title abstract 3
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- 239000002777 nucleoside Substances 0.000 title abstract 2
- 102000008100 Human Serum Albumin Human genes 0.000 title 1
- 108091006905 Human Serum Albumin Proteins 0.000 title 1
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- UDMBCSSLTHHNCD-UHTZMRCNSA-N [(2r,3s,4s,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O UDMBCSSLTHHNCD-UHTZMRCNSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- JBFYUZGYRGXSFL-UHFFFAOYSA-N imidazolide Chemical compound C1=C[N-]C=N1 JBFYUZGYRGXSFL-UHFFFAOYSA-N 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Effettuando la reazione di coniugazione tra un nucleoside antivirale fosforilato, in particolare adenina arabinoside monofosfato, in forma di imidazolide con albumina umana lattosaminata a pH superiore a 7,5 si ottengono nel coniugato risultante rapporti molari farmaco/L-HSA almeno uguali a quelli ottenuti usando ECDI senza i problemi ed inconvenienti collaterali presentati da questi ultimi. Di preferenza la reazione di coniugazione viene effettuata a temperatura di 37° C, ed a pH di 8,5-9,5.
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI922673A IT1256110B (it) | 1992-11-23 | 1992-11-23 | Procedimento di coniugazione di nucleosidi antivirali con albumina umana lattosaminata |
PT94901834T PT624098E (pt) | 1992-11-23 | 1993-11-20 | Processo de conjugacao de nucleosidos antivirais com albumina humana lactosaminada |
AT94901834T ATE190504T1 (de) | 1992-11-23 | 1993-11-20 | Konjugation von antivirale nukleosiden mit lactosaminaten-human-albumin |
DK94901834T DK0624098T3 (da) | 1992-11-23 | 1993-11-20 | Fremgangsmåde til konjugering af antivirale nukleosider med lactosamineret humant albumin |
PCT/EP1993/003261 WO1994012218A1 (en) | 1992-11-23 | 1993-11-20 | Process of conjugation of antiviral nucleosides with lactosaminated human albumin |
DE69328082T DE69328082T2 (de) | 1992-11-23 | 1993-11-20 | Konjugation von antivirale Nukleosiden mit Lactosaminaten-Human-Albumin |
EP94901834A EP0624098B1 (en) | 1992-11-23 | 1993-11-20 | Process of conjugation of antiviral nucleosides with lactosaminated human albumin |
US08/256,415 US5594110A (en) | 1992-11-23 | 1993-11-20 | Process of conjugation of antiviral nucleosides with lactosaminated human albumin |
AU56262/94A AU5626294A (en) | 1992-11-23 | 1993-11-20 | Process of conjugation of antiviral nucleosides with lactosaminated human albumin |
ES94901834T ES2144046T3 (es) | 1992-11-23 | 1993-11-20 | Procedimiento de conjugacion de nucleosidos antivirales con albumina humana lactosaminada. |
GR20000401297T GR3033611T3 (en) | 1992-11-23 | 2000-06-07 | Process of conjugation of antiviral nucleosides with lactosaminated human albumin. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI922673A IT1256110B (it) | 1992-11-23 | 1992-11-23 | Procedimento di coniugazione di nucleosidi antivirali con albumina umana lattosaminata |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI922673A0 ITMI922673A0 (it) | 1992-11-23 |
ITMI922673A1 ITMI922673A1 (it) | 1994-05-23 |
IT1256110B true IT1256110B (it) | 1995-11-28 |
Family
ID=11364330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI922673A IT1256110B (it) | 1992-11-23 | 1992-11-23 | Procedimento di coniugazione di nucleosidi antivirali con albumina umana lattosaminata |
Country Status (11)
Country | Link |
---|---|
US (1) | US5594110A (it) |
EP (1) | EP0624098B1 (it) |
AT (1) | ATE190504T1 (it) |
AU (1) | AU5626294A (it) |
DE (1) | DE69328082T2 (it) |
DK (1) | DK0624098T3 (it) |
ES (1) | ES2144046T3 (it) |
GR (1) | GR3033611T3 (it) |
IT (1) | IT1256110B (it) |
PT (1) | PT624098E (it) |
WO (1) | WO1994012218A1 (it) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5632915A (en) * | 1994-08-29 | 1997-05-27 | Gerber Garment Technology, Inc. | Laser material processing apparatus and a work table therefor |
US5693791A (en) * | 1995-04-11 | 1997-12-02 | Truett; William L. | Antibiotics and process for preparation |
US20020099013A1 (en) * | 2000-11-14 | 2002-07-25 | Thomas Piccariello | Active agent delivery systems and methods for protecting and administering active agents |
US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
ITMI20010027A1 (it) * | 2001-01-10 | 2002-07-10 | Uni Di Bologna Dipartimento Di | Composizioni teraputiche per una chemioterapia locoregionale non invasiva delle micrometastasi epatiche |
US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
EP2069396B1 (en) | 2006-09-08 | 2015-10-21 | Ambrx, Inc. | Modified human plasma polypeptide or fc scaffolds and their uses |
SI2419732T1 (sl) * | 2009-04-15 | 2020-03-31 | Abraxis Bioscience, Llc | Sestave nanodelcev brez prionov in metode za njihovo pripravo |
US9534243B2 (en) | 2013-02-07 | 2017-01-03 | The United States Of America, As Represented By The Secretary Of Commerce | Nucleotide analogs and process for making same enzyme |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1177381B (it) * | 1984-12-11 | 1987-08-26 | Baldacci Lab Spa | Metodo per la preparazione di coniugati della adenina-9-beta-d-arabino furano-side 5' monofosfato con albumina umana lattosaminata, coniugati risultanti e relative composizioi terapeuticamente attive |
IT1207507B (it) * | 1985-10-21 | 1989-05-25 | Baldacci Lab Spa | Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono. |
-
1992
- 1992-11-23 IT ITMI922673A patent/IT1256110B/it active IP Right Grant
-
1993
- 1993-11-20 DK DK94901834T patent/DK0624098T3/da active
- 1993-11-20 US US08/256,415 patent/US5594110A/en not_active Expired - Fee Related
- 1993-11-20 AT AT94901834T patent/ATE190504T1/de not_active IP Right Cessation
- 1993-11-20 DE DE69328082T patent/DE69328082T2/de not_active Expired - Fee Related
- 1993-11-20 ES ES94901834T patent/ES2144046T3/es not_active Expired - Lifetime
- 1993-11-20 AU AU56262/94A patent/AU5626294A/en not_active Abandoned
- 1993-11-20 PT PT94901834T patent/PT624098E/pt unknown
- 1993-11-20 EP EP94901834A patent/EP0624098B1/en not_active Expired - Lifetime
- 1993-11-20 WO PCT/EP1993/003261 patent/WO1994012218A1/en active IP Right Grant
-
2000
- 2000-06-07 GR GR20000401297T patent/GR3033611T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69328082T2 (de) | 2000-08-24 |
US5594110A (en) | 1997-01-14 |
AU5626294A (en) | 1994-06-22 |
EP0624098B1 (en) | 2000-03-15 |
DE69328082D1 (de) | 2000-04-20 |
ITMI922673A0 (it) | 1992-11-23 |
EP0624098A1 (en) | 1994-11-17 |
ES2144046T3 (es) | 2000-06-01 |
DK0624098T3 (da) | 2000-06-05 |
GR3033611T3 (en) | 2000-10-31 |
WO1994012218A1 (en) | 1994-06-09 |
ATE190504T1 (de) | 2000-04-15 |
ITMI922673A1 (it) | 1994-05-23 |
PT624098E (pt) | 2000-08-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971127 |