ATE59627T1 - Perfluorkohlenwasserstoffemulsionen in waessrigen medien. - Google Patents

Perfluorkohlenwasserstoffemulsionen in waessrigen medien.

Info

Publication number
ATE59627T1
ATE59627T1 AT86301382T AT86301382T ATE59627T1 AT E59627 T1 ATE59627 T1 AT E59627T1 AT 86301382 T AT86301382 T AT 86301382T AT 86301382 T AT86301382 T AT 86301382T AT E59627 T1 ATE59627 T1 AT E59627T1
Authority
AT
Austria
Prior art keywords
aqueous media
perfluorocarbon emulsions
fluorinated compound
emulsions
perfluorocarbon
Prior art date
Application number
AT86301382T
Other languages
English (en)
Inventor
Stanley Stewart Davis
David Edward Mudge Wotton
Original Assignee
Isc Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isc Chemicals Ltd filed Critical Isc Chemicals Ltd
Application granted granted Critical
Publication of ATE59627T1 publication Critical patent/ATE59627T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026Blood substitute; Oxygen transporting formulations; Plasma extender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/38Separation; Purification; Stabilisation; Use of additives
    • C07C17/42Use of additives, e.g. for stabilisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C23/00Compounds containing at least one halogen atom bound to a ring other than a six-membered aromatic ring
    • C07C23/18Polycyclic halogenated hydrocarbons
    • C07C23/20Polycyclic halogenated hydrocarbons with condensed rings none of which is aromatic
    • C07C23/36Halogenated completely or partially hydrogenated naphthalenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C23/00Compounds containing at least one halogen atom bound to a ring other than a six-membered aromatic ring
    • C07C23/18Polycyclic halogenated hydrocarbons
    • C07C23/20Polycyclic halogenated hydrocarbons with condensed rings none of which is aromatic
    • C07C23/38Polycyclic halogenated hydrocarbons with condensed rings none of which is aromatic with three condensed rings
    • C07C23/40Halogenated completely or partially hydrogenated fluorenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C23/00Compounds containing at least one halogen atom bound to a ring other than a six-membered aromatic ring
    • C07C23/18Polycyclic halogenated hydrocarbons
    • C07C23/20Polycyclic halogenated hydrocarbons with condensed rings none of which is aromatic
    • C07C23/38Polycyclic halogenated hydrocarbons with condensed rings none of which is aromatic with three condensed rings
    • C07C23/42Halogenated completely or partially hydrogenated anthracenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C23/00Compounds containing at least one halogen atom bound to a ring other than a six-membered aromatic ring
    • C07C23/18Polycyclic halogenated hydrocarbons
    • C07C23/20Polycyclic halogenated hydrocarbons with condensed rings none of which is aromatic
    • C07C23/38Polycyclic halogenated hydrocarbons with condensed rings none of which is aromatic with three condensed rings
    • C07C23/44Halogenated completely or partially hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT86301382T 1985-02-26 1986-02-26 Perfluorkohlenwasserstoffemulsionen in waessrigen medien. ATE59627T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858504916A GB8504916D0 (en) 1985-02-26 1985-02-26 Emulsions of perfluorocarbons in aqueous media
EP86301382A EP0196776B1 (de) 1985-02-26 1986-02-26 Perfluorkohlenwasserstoffemulsionen in wässrigen Medien

Publications (1)

Publication Number Publication Date
ATE59627T1 true ATE59627T1 (de) 1991-01-15

Family

ID=10575097

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86301382T ATE59627T1 (de) 1985-02-26 1986-02-26 Perfluorkohlenwasserstoffemulsionen in waessrigen medien.

Country Status (6)

Country Link
US (1) US4859363A (de)
EP (1) EP0196776B1 (de)
JP (1) JPH0667468B2 (de)
AT (1) ATE59627T1 (de)
DE (1) DE3676330D1 (de)
GB (2) GB8504916D0 (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL82308A (en) * 1986-06-26 1990-11-29 Ausimont Spa Microemulsions containing perfluoropolyethers
US5243044A (en) * 1986-08-25 1993-09-07 International Therapeutics, Inc. Compounds of perfluoro[3,3,3]propellene and perfluoro hexamethylenetetramine
DE4019061A1 (de) * 1989-08-30 1991-03-07 Kali Chemie Ag Verfahren zur herstellung perfluorierter heterocyclischer verbindungen und nach diesem verfahren hergestellte verbindungen
DE4019062A1 (de) * 1989-08-30 1991-03-07 Kali Chemie Ag Stabilisierung von perfluorcarbonemulsionen und als emulsionsstabilisierende zusaetze verwendbare perfluorierte heterocyclische verbindungen
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (de) * 1990-04-02 1993-05-01 Sint Sa
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5146014A (en) * 1991-07-02 1992-09-08 Air Products And Chemicals, Inc. Perfluoroethyldimethyl cyclohexane
FR2679150A1 (fr) * 1991-07-17 1993-01-22 Atta Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations.
RU2114637C1 (ru) * 1991-09-17 1998-07-10 Сонус Фармасьютикалз, Инк. Биосовместимая контрастная среда и способ получения ультразвукового изображения
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5277176A (en) * 1992-06-29 1994-01-11 Habashi Nader M Extracorporeal lung assistance apparatus and process
US5628930A (en) * 1992-10-27 1997-05-13 Alliance Pharmaceutical Corp. Stabilization of fluorocarbon emulsions
US5595687A (en) 1992-10-30 1997-01-21 Thomas Jefferson University Emulsion stability
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
NZ262237A (en) * 1993-01-25 1997-06-24 Sonus Pharma Inc Ultrasound contrast agents comprising phase shift colloids having a boiling point below the body temperature of the animal it is used in
US5635538A (en) * 1993-03-16 1997-06-03 Alliance Pharmaceutical Corp. Fluorocarbon emulsions with reduced pulmonary gas-trapping properties
DE69333755T2 (de) * 1993-03-26 2006-03-30 W.L. Gore & Associates, Inc., Newark Verwendung eines beschichteten Polytetrafluorethylengegenstandes für Kleidung
RU2138293C1 (ru) 1993-12-15 1999-09-27 Бракко Рисерч С.А. Контрастные вещества для ультразвуковой эхографии, контрастные средства, содержащие эти вещества, и способы их приготовления
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
WO1997025978A1 (en) * 1996-01-15 1997-07-24 BELOYARTSEV, Arkady Felixovich Method of obtaining perfluorocarbon emulsions for medical purposes
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
NZ331460A (en) * 1996-03-05 1998-12-23 Acusphere Inc Microencapsulated fluorinated gases for use as imaging agents
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
RU2154471C2 (ru) * 1998-05-26 2000-08-20 Межотраслевой научно-технический комплекс "Микрохирургия глаза" Способ предоперационной подготовки больных
CN1215834C (zh) * 2000-07-20 2005-08-24 佩尔夫托拉科研生产公众股份公司 一种用于医药目的的全氟有机化合物的乳液、其制备方法和利用其治疗和预防疾病的方法
FR2827514B1 (fr) * 2001-07-18 2003-09-12 Oreal Composition a usage topique contenant un polymere diblocs
ES2305368T3 (es) * 2002-05-10 2008-11-01 THE PROCTER & GAMBLE COMPANY Tisu estampado en relieve que tiene fibras superficiales sueltas y metodo para su produccion.
RU2240108C1 (ru) * 2003-09-04 2004-11-20 Кукушкин Николай Ильич Эмульсия перфторорганических соединений с газотранспортными свойствами
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US20070026024A1 (en) * 2005-07-27 2007-02-01 Drees Thomas C Compositions and methods for emulsifying a pefluorocarbon with an oxygen-carrying surfactant
EP2364774A3 (de) 2006-01-11 2014-06-04 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen Und Verfahren Zur Verwendung Bei Der Bildung Und Kontrolle Von Nanoreaktoren
ATE540750T1 (de) 2006-05-11 2012-01-15 Raindance Technologies Inc Mikrofluidische vorrichtung und verfahren
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP3536396B1 (de) * 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (de) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken
US20100093873A1 (en) * 2008-10-02 2010-04-15 Goldfischer Sidney L Methods of improving therapy of perfluorocarbons (PFC)
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP3392349A1 (de) 2010-02-12 2018-10-24 Raindance Technologies, Inc. Digitale analyse von analyten
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP2622103B2 (de) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwichassays in tröpfchen
EP3859011A1 (de) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Verfahren zur bildung gemischter tröpfchen
EP2675819B1 (de) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Zusammensetzungen und verfahren für molekulare etikettierung
EP3709018A1 (de) 2011-06-02 2020-09-16 Bio-Rad Laboratories, Inc. Mikrofluidische vorrichtung zum nachweis von komponenten einer chemischen reaktion
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
RU2518313C2 (ru) * 2012-05-17 2014-06-10 Сергей Иванович Воробьев Перфторуглеродный кровезаменитель - газотранспортный заменитель донорской крови: состав и средство лечения
DE102012014465A1 (de) 2012-07-18 2014-01-23 Gmbu E.V., Fachsektion Dresden Perfluorocarbonemulsion
DE102012014464A1 (de) 2012-07-18 2014-01-23 Gmbu E.V., Fachsektion Dresden Formulierung zur topischen Anwendung von Perfluorocarbonverbindungen und Verfahren zur Herstellung
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3775489A (en) * 1971-04-14 1973-11-27 J Margrave Process for fluorination of aromatic and polynuclear hydrocarbon compounds and fluorocarbons produced thereby
US3823091A (en) * 1971-05-19 1974-07-09 Green Cross Corp Stable emulsion of fluorocarbon particles
US3778381A (en) * 1972-04-24 1973-12-11 Allied Chem Fluorocarbon microemulsions
US3911138B1 (en) * 1973-02-26 1996-10-29 Childrens Hosp Medical Center Artificial blood and method for supporting oxygen transport in animals
US3993581A (en) * 1973-10-05 1976-11-23 The Green Cross Corporation Process for preparing stable oxygen transferable emulsion
IT1050731B (it) * 1974-12-09 1981-03-20 Childrens Hosp Medical Center Composti perfluoropoliciclici per l impiego come sangue sintetico e ambiente di ferfusione
JPS5347787A (en) * 1976-10-13 1978-04-28 Toshiba Corp Photographing method and device for stereo x-rays
JPS5439834A (en) * 1977-09-02 1979-03-27 Matsushita Electric Industrial Co Ltd Method of making anode electrode plate for alkaline storage battery
JPS6033367B2 (ja) * 1978-11-24 1985-08-02 株式会社ミドリ十字 酸素運搬輸液
FR2515198A1 (fr) * 1981-10-22 1983-04-29 Centre Nat Rech Scient Microemulsions aqueuses de fluorocarbures indefiniment stables a une temperature donnee, procede d'obtention et application a titre de transporteurs d'oxygene
JPS59175421A (ja) * 1983-03-24 1984-10-04 Tetsuzou Agishi 血液浄化剤

Also Published As

Publication number Publication date
GB2171330A (en) 1986-08-28
US4859363A (en) 1989-08-22
GB8504916D0 (en) 1985-03-27
DE3676330D1 (de) 1991-02-07
GB8604709D0 (en) 1986-04-03
JPS61242632A (ja) 1986-10-28
EP0196776A1 (de) 1986-10-08
EP0196776B1 (de) 1991-01-02
JPH0667468B2 (ja) 1994-08-31
GB2171330B (en) 1988-06-08

Similar Documents

Publication Publication Date Title
ATE59627T1 (de) Perfluorkohlenwasserstoffemulsionen in waessrigen medien.
FR2679150B1 (de)
ES2025064B3 (es) Mezclas preservadoras.
KR890006749A (ko) 작용성 퍼플루오로폴리에테르를 함유하는 수성 마이크로에멀션
ATE208621T1 (de) Stabilisierung der prostaglandinzusammensetzungen
DE3873375D1 (de) Kosmetische praeparate.
KR960702733A (ko) 안정한 유중수형 유제(stable water-in-oil emulsions)
DE69417955D1 (de) Kraftstoffzusätze
KR870005968A (ko) 아미드 유도체 및 이를 함유하는 외용약제
DE69002697D1 (de) Carboplatinzusammensetzung.
DE69824326D1 (de) Pharmazeutische Emulsion enthaltend Sorbinsäure, Na-EDTA und Borsäure
KR920700279A (ko) 저 표면장력 황산 조성물
EP0224167A3 (de) Verwendung von Polyglykoldialkylethern als Viskositätsregler für wässrige Aniontensidlösungen
KR890006639A (ko) 벤조티아진 디옥사이드 유도체
DE69401273D1 (de) Eine emulsion von öl in wasser
KR920006480A (ko) 활성 매트릭스에 적용하기 위한 네마틱 액정 조성물
KR830005325A (ko) 수용성 화학 발광 시스템
DE58900155D1 (de) Verlegung von fliesen mittels eines fliesenklebstoffs.
FI891033A0 (fi) Lim.
ES2079066T3 (es) Preparacion emulsionada para el cuidado del cabello.
JPS55147218A (en) Preparation of emulsion of superfine fluorocarbon particle for medical use
KR930016673A (ko) 퍼플루오로폴리에테르 오일에 의해 작동되는 인공진공펌프의 역행 저감법
KR910009258A (ko) 니트록시닐과 레바미솔 복합주사제의 제조방법
KR900012884A (ko) (+)1-[(3,4,5-트리메톡시)-벤질옥시메틸]-1-페닐-N,N-디메틸-n-프로필아민, 그의 제조방법 및 치료학적 용도
ATE32885T1 (de) Pentahydroperfluoralkylamin-n-oxide.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee