ATE56435T1 - Indolinonderivate. - Google Patents
Indolinonderivate.Info
- Publication number
- ATE56435T1 ATE56435T1 AT87305984T AT87305984T ATE56435T1 AT E56435 T1 ATE56435 T1 AT E56435T1 AT 87305984 T AT87305984 T AT 87305984T AT 87305984 T AT87305984 T AT 87305984T AT E56435 T1 ATE56435 T1 AT E56435T1
- Authority
- AT
- Austria
- Prior art keywords
- indoline
- oxo
- acetic acid
- dichlorobenzyl
- compounds
- Prior art date
Links
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 2
- JKJISQOWTFXMRR-UHFFFAOYSA-N 2-(2-oxo-3h-indol-1-yl)acetic acid Chemical compound C1=CC=C2N(CC(=O)O)C(=O)CC2=C1 JKJISQOWTFXMRR-UHFFFAOYSA-N 0.000 abstract 1
- AJPROLABJSJVQL-UHFFFAOYSA-N 2-[3-[(3,4-dichlorophenyl)methyl]-2-oxo-3h-indol-1-yl]acetic acid Chemical compound C12=CC=CC=C2N(CC(=O)O)C(=O)C1CC1=CC=C(Cl)C(Cl)=C1 AJPROLABJSJVQL-UHFFFAOYSA-N 0.000 abstract 1
- KSWZALKIOKZGJX-UHFFFAOYSA-N 2-[3-[(3,4-dichlorophenyl)methyl]-6-hydroxy-2-oxo-3h-indol-1-yl]acetic acid Chemical compound C12=CC=C(O)C=C2N(CC(=O)O)C(=O)C1CC1=CC=C(Cl)C(Cl)=C1 KSWZALKIOKZGJX-UHFFFAOYSA-N 0.000 abstract 1
- QYCLUYBUTDMHJI-UHFFFAOYSA-N 2-[3-[(3,4-dichlorophenyl)methyl]-6-methoxy-2-oxo-3h-indol-1-yl]acetic acid Chemical compound O=C1N(CC(O)=O)C2=CC(OC)=CC=C2C1CC1=CC=C(Cl)C(Cl)=C1 QYCLUYBUTDMHJI-UHFFFAOYSA-N 0.000 abstract 1
- BGEMJGYOGOPLHL-UHFFFAOYSA-N 2-[3-[1-(3,4-dichlorophenyl)ethyl]-2-oxo-3h-indol-1-yl]acetic acid Chemical compound O=C1N(CC(O)=O)C2=CC=CC=C2C1C(C)C1=CC=C(Cl)C(Cl)=C1 BGEMJGYOGOPLHL-UHFFFAOYSA-N 0.000 abstract 1
- RFKBMPCMUIGTCJ-UHFFFAOYSA-N 2-[5-chloro-3-[(3,4-dichlorophenyl)methyl]-2-oxo-3h-indol-1-yl]acetic acid Chemical compound C12=CC(Cl)=CC=C2N(CC(=O)O)C(=O)C1CC1=CC=C(Cl)C(Cl)=C1 RFKBMPCMUIGTCJ-UHFFFAOYSA-N 0.000 abstract 1
- -1 3,4-dichloro- alpha -methylbenzyl moiety Chemical group 0.000 abstract 1
- 125000006512 3,4-dichlorobenzyl group Chemical group [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C([H])([H])* 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
- 229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1986/001429 WO1993012786A1 (en) | 1986-07-10 | 1986-07-10 | Indolinone derivatives |
| EP87305984A EP0252713B1 (de) | 1986-07-10 | 1987-07-07 | Indolinonderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE56435T1 true ATE56435T1 (de) | 1990-09-15 |
Family
ID=22195566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87305984T ATE56435T1 (de) | 1986-07-10 | 1987-07-07 | Indolinonderivate. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0252713B1 (de) |
| JP (1) | JPH0643393B2 (de) |
| AT (1) | ATE56435T1 (de) |
| DE (1) | DE3764886D1 (de) |
| DK (1) | DK355287A (de) |
| ES (1) | ES2031506T3 (de) |
| GR (1) | GR3000854T3 (de) |
| IE (1) | IE59995B1 (de) |
| PT (1) | PT85294B (de) |
| WO (1) | WO1993012786A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5064852A (en) * | 1988-12-16 | 1991-11-12 | Pfizer Inc. | Indolinone derivatives |
| JPH04217684A (ja) * | 1990-05-30 | 1992-08-07 | Shionogi & Co Ltd | アルド−ス還元酵素阻害物質 |
| US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6147106A (en) | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| AU7622698A (en) * | 1996-12-05 | 1998-06-29 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| US6316429B1 (en) | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
| US6486185B1 (en) | 1997-05-07 | 2002-11-26 | Sugen, Inc. | 3-heteroarylidene-2-indolinone protein kinase inhibitors |
| SK7522001A3 (en) | 1998-03-31 | 2002-02-05 | Inst For Pharm Discovery Inc | Substituted indolealkanoic acids |
| US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| TNSN99224A1 (fr) | 1998-12-01 | 2005-11-10 | Inst For Pharm Discovery Inc | Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique |
| AR034118A1 (es) | 2000-02-15 | 2004-02-04 | Sugen Inc | Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis |
| MY128449A (en) | 2000-05-24 | 2007-02-28 | Sugen Inc | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| AU2001268154A1 (en) | 2000-06-02 | 2001-12-17 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| WO2002096361A2 (en) | 2001-05-30 | 2002-12-05 | Sugen, Inc. | 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors |
| MXPA04003385A (es) | 2001-10-10 | 2005-04-11 | Sugen Inc | Derivados de 3-?4-substituido con heterociclilo)-pirrol-2-ilmetilidene?-2-indolinona como inhibidores de cinasa. |
| DE10210195B4 (de) | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| US7659300B2 (en) * | 2004-09-08 | 2010-02-09 | Merck Sharp & Dohme Corp. | Monocyclic anilide spirolactam CGRP receptor antagonists |
| WO2006105795A1 (en) * | 2005-04-08 | 2006-10-12 | Leo Pharma A/S | Novel indolinone derivatives |
| MY145694A (en) | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
| AR056968A1 (es) | 2005-04-11 | 2007-11-07 | Xenon Pharmaceuticals Inc | Compuestos espiro-oxindol y composiciones farmacéuticas |
| AR063280A1 (es) | 2006-10-12 | 2009-01-21 | Xenon Pharmaceuticals Inc | Uso de compuestos de espiro-oxindol como agentes terapeuticos |
| WO2010045197A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals, Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| CN105218565A (zh) | 2008-10-17 | 2016-01-06 | 泽农医药公司 | 螺羟吲哚化合物及其作为治疗剂的用途 |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| CN102753556B (zh) | 2009-10-14 | 2015-05-13 | 泽农医药公司 | 螺-羟吲哚化合物的合成方法 |
| NZ601667A (en) | 2010-02-26 | 2014-10-31 | Xenon Pharmaceuticals Inc | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
| TW202502735A (zh) * | 2023-03-02 | 2025-01-16 | 印度商吉德斯生命科學有限公司 | 新穎atx抑制劑 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3393208A (en) * | 1965-10-22 | 1968-07-16 | Mcneilab Inc | 6h-benzo[5, 6] cyclohept[1, 2, 3-cd]indolin-1, 6-diones |
| US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
| US4053613A (en) * | 1975-09-17 | 1977-10-11 | E. R. Squibb & Sons, Inc. | 1,3,thiazolinyl and 1,3 thiazinyl substituted indolinones |
| FR2355006A1 (fr) * | 1976-06-17 | 1978-01-13 | Labaz | Nouveaux derives d'indole et procedes pour les preparer |
| EP0022317B1 (de) * | 1979-06-12 | 1983-09-21 | Fujisawa Pharmaceutical Co., Ltd. | 2-Oxo-benzothiazolin-, Benzoxazolin- oder Indolin-Derivate, deren Herstellung und derartige Verbindungen enthaltende pharmazeutische Zusammensetzungen |
-
1986
- 1986-07-10 WO PCT/US1986/001429 patent/WO1993012786A1/en not_active Ceased
-
1987
- 1987-07-07 ES ES198787305984T patent/ES2031506T3/es not_active Expired - Lifetime
- 1987-07-07 DE DE8787305984T patent/DE3764886D1/de not_active Expired - Lifetime
- 1987-07-07 AT AT87305984T patent/ATE56435T1/de not_active IP Right Cessation
- 1987-07-07 EP EP87305984A patent/EP0252713B1/de not_active Expired - Lifetime
- 1987-07-09 IE IE184387A patent/IE59995B1/en not_active IP Right Cessation
- 1987-07-09 JP JP62172054A patent/JPH0643393B2/ja not_active Expired - Lifetime
- 1987-07-09 PT PT85294A patent/PT85294B/pt not_active IP Right Cessation
- 1987-07-09 DK DK355287A patent/DK355287A/da not_active Application Discontinuation
-
1990
- 1990-09-20 GR GR90400685T patent/GR3000854T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK355287A (da) | 1988-04-08 |
| PT85294A (en) | 1987-08-01 |
| IE871843L (en) | 1988-01-10 |
| DE3764886D1 (de) | 1990-10-18 |
| ES2031506T3 (es) | 1992-12-16 |
| IE59995B1 (en) | 1994-05-18 |
| EP0252713A1 (de) | 1988-01-13 |
| PT85294B (pt) | 1990-04-30 |
| DK355287D0 (da) | 1987-07-09 |
| EP0252713B1 (de) | 1990-09-12 |
| GR3000854T3 (en) | 1991-11-15 |
| WO1993012786A1 (en) | 1993-07-08 |
| JPH0643393B2 (ja) | 1994-06-08 |
| JPS6323863A (ja) | 1988-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |