ATE55695T1 - Verwendung von defibrotid zur herstellung pharmazeutischer zusammensetzungen zur behandlung peripherer arteriopathien. - Google Patents
Verwendung von defibrotid zur herstellung pharmazeutischer zusammensetzungen zur behandlung peripherer arteriopathien.Info
- Publication number
- ATE55695T1 ATE55695T1 AT84201287T AT84201287T ATE55695T1 AT E55695 T1 ATE55695 T1 AT E55695T1 AT 84201287 T AT84201287 T AT 84201287T AT 84201287 T AT84201287 T AT 84201287T AT E55695 T1 ATE55695 T1 AT E55695T1
- Authority
- AT
- Austria
- Prior art keywords
- defibrotide
- pharmaceutical compositions
- preparation
- treatment
- peripheral arteriopathies
- Prior art date
Links
- JNWFIPVDEINBAI-UHFFFAOYSA-N [5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C(C(C)C)=CC(C=2N(C(=O)NN=2)C=2C=C3C=CN(C)C3=CC=2)=C1O JNWFIPVDEINBAI-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004120 defibrotide Drugs 0.000 title abstract 2
- 230000002093 peripheral effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 200000000007 Arterial disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22855/83A IT1170214B (it) | 1983-09-12 | 1983-09-12 | Composizione farmaceutica per la cura delle arteriopatie periferiche |
| EP84201287A EP0137543B1 (en) | 1983-09-12 | 1984-09-07 | Use of defibrotide for the preparation of pharmaceutical compositions for the therapeutical treatment of peripheral arteriopathies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE55695T1 true ATE55695T1 (de) | 1990-09-15 |
Family
ID=11201215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84201287T ATE55695T1 (de) | 1983-09-12 | 1984-09-07 | Verwendung von defibrotid zur herstellung pharmazeutischer zusammensetzungen zur behandlung peripherer arteriopathien. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5081109A (enExample) |
| EP (1) | EP0137543B1 (enExample) |
| JP (1) | JPH0647545B2 (enExample) |
| AT (1) | ATE55695T1 (enExample) |
| BE (1) | BE900564A (enExample) |
| CH (1) | CH661870A5 (enExample) |
| DE (1) | DE3433328A1 (enExample) |
| IT (1) | IT1170214B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1223322B (it) * | 1987-10-23 | 1990-09-19 | Crinos Industria Farmaco | Metodo per prevenire la formazione di coaguli sanguigni nel circuito extracorporeo di apparecchi di dialisi a composizione utile per esso |
| IT1231509B (it) * | 1989-09-07 | 1991-12-07 | Crinos Industria Farmaco | Composizione farmceutica ad uso topico per la terapia della fragilita' capillare. |
| US6699985B2 (en) * | 1991-08-21 | 2004-03-02 | Arsinur Burcoglu | Method of treating HIV infection and related secondary infections thereof |
| DE19610345C1 (de) | 1996-03-18 | 1997-11-20 | Krupp Vdm Gmbh | Katalysator zur Oxidation von Abwasserverunreinigungen mittels Persäuren und/oder Wasserstoffperoxid |
| HK1044896A1 (zh) * | 1997-04-28 | 2002-11-08 | Burcoglu Arsinur | 治疗hiv感染和与之有关的继发感染的方法 |
| ITMI20031714A1 (it) * | 2003-09-05 | 2005-03-06 | Gentium Spa | Formazioni ad azione antitumorale. |
| MX2007010754A (es) * | 2005-03-03 | 2007-11-07 | Gentium Spa | Defibrotide y/u oligodeoxiribonucleotidos para tratar tumores dependientes de angiogenesis. |
| EP1891952B1 (en) * | 2006-05-04 | 2011-10-05 | LEK Pharmaceuticals d.d. | Pharmaceutical composition of olmesartan medoxomil |
| EP1872787A1 (en) * | 2006-06-27 | 2008-01-02 | Gentium S.p.A. | Use of defibrotide for the inhibition of heparanase |
| EP1982722A1 (en) * | 2007-04-16 | 2008-10-22 | Gentium S.p.A. | Use of oligotide for the treatment of renal diseases |
| EP2103689A1 (en) * | 2008-03-19 | 2009-09-23 | Gentium S.p.A. | Synthetic phosphodiester oligonucleotides and therapeutical uses thereof |
| DK2637672T3 (en) | 2010-11-12 | 2018-10-22 | Gentium S R L | DEFIBROTID FOR USE IN PROPHYLAXY AND / OR TREATMENT OF GRAPHIC VERSUS HOST DISEASE (GVHD) |
| KR20150044877A (ko) | 2012-06-22 | 2015-04-27 | 젠티엄 에스피에이 | 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법 |
| EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| KR20200121780A (ko) | 2017-08-03 | 2020-10-26 | 재즈 파마슈티칼즈 아일랜드 리미티드 | 높은 농도에서 핵산을 포함하는 제제 |
| BR112020020865A2 (pt) | 2018-04-12 | 2021-01-19 | Jazz Pharmaceuticals, Inc. | Defibrotida para prevenção e tratamento da síndrome de liberação de citocinas e neurotoxicidade associadas à imunodepleção |
| US20220023533A1 (en) | 2018-12-07 | 2022-01-27 | Jazz Phrmaceticals Ireland Limited | Subcutaneous delivery of high concentration formulations |
| EP4110287A1 (en) | 2020-02-28 | 2023-01-04 | Jazz Pharmaceuticals Ireland Limited | Delivery of low viscosity formulations |
| US20230086833A1 (en) | 2020-04-17 | 2023-03-23 | Jazz Pharmaceuticals Ireland Limited | Defibrotide treatment for the prevention of organ rejection and injury |
| TW202308659A (zh) | 2021-05-06 | 2023-03-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 用於急性呼吸窘迫症候群之治療及預防的去纖維蛋白多核苷酸 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2154279A1 (de) * | 1970-11-03 | 1972-05-25 | Crinos Industria Farmaco | Medikamente für das fibrinolytische System |
| US3899481A (en) * | 1970-11-03 | 1975-08-12 | Crinos Industria Farmaco | Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs |
| IT1043823B (it) * | 1970-11-03 | 1980-02-29 | Prephar | Procedimento per l estrazione di acidi nucleici da organi animali |
| US4485105A (en) * | 1978-10-12 | 1984-11-27 | American Cyanamid Company | Method of treating hyperlipidemia with 4-(monoalkylamino)benzoic acid amides |
| US4416877A (en) * | 1979-02-13 | 1983-11-22 | Symphar S.A. | Anti-atherosclerotic pharmaceutical compositions containing diphosphonate compounds |
| GB2043072B (en) * | 1979-02-13 | 1983-11-23 | Symphar Sa | Diphosphonate compounds |
| JPS5675474A (en) * | 1979-11-22 | 1981-06-22 | Chugai Pharmaceut Co Ltd | Nicotinamide derivative and medicine containing the same |
| US4351950A (en) * | 1980-01-02 | 1982-09-28 | Warner-Lambert Company | Anti-arteriosclerotic agents |
| US4450272A (en) * | 1982-05-06 | 1984-05-22 | American Cyanamid Company | Antiatherosclerotic 1-piperazine-thicarboxamides |
| IT1167197B (it) * | 1983-07-25 | 1987-05-13 | Bellon Roger Schoum Rbs Pharma | Impiego della fenpiramina quale farmaco antiaggregante piastrinico,vasodilatatore,antitrombotico e antianginoso |
| IT1170215B (it) * | 1983-09-12 | 1987-06-03 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento di stati di insufficienza renale acuta |
| IT1206341B (it) * | 1984-02-16 | 1989-04-14 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio. |
-
1983
- 1983-09-12 IT IT22855/83A patent/IT1170214B/it active
-
1984
- 1984-09-07 EP EP84201287A patent/EP0137543B1/en not_active Expired - Lifetime
- 1984-09-07 CH CH4280/84A patent/CH661870A5/it not_active IP Right Cessation
- 1984-09-07 AT AT84201287T patent/ATE55695T1/de active
- 1984-09-11 DE DE19843433328 patent/DE3433328A1/de active Granted
- 1984-09-12 BE BE0/213641A patent/BE900564A/fr not_active IP Right Cessation
- 1984-09-12 JP JP59191391A patent/JPH0647545B2/ja not_active Expired - Lifetime
-
1988
- 1988-07-05 US US07/218,514 patent/US5081109A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0647545B2 (ja) | 1994-06-22 |
| DE3433328C2 (enExample) | 1993-08-05 |
| JPS6169722A (ja) | 1986-04-10 |
| EP0137543B1 (en) | 1990-08-22 |
| EP0137543A3 (en) | 1987-09-02 |
| CH661870A5 (it) | 1987-08-31 |
| US5081109A (en) | 1992-01-14 |
| IT1170214B (it) | 1987-06-03 |
| IT8322855A0 (it) | 1983-09-12 |
| BE900564A (fr) | 1985-01-02 |
| DE3433328A1 (de) | 1985-03-28 |
| EP0137543A2 (en) | 1985-04-17 |
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