ATE550343T1 - Für die synthese von gemcitabin geeignetes naphthalin-2-carboxylatderivat und verfahren zu dessen herstellung - Google Patents

Für die synthese von gemcitabin geeignetes naphthalin-2-carboxylatderivat und verfahren zu dessen herstellung

Info

Publication number
ATE550343T1
ATE550343T1 AT07793303T AT07793303T ATE550343T1 AT E550343 T1 ATE550343 T1 AT E550343T1 AT 07793303 T AT07793303 T AT 07793303T AT 07793303 T AT07793303 T AT 07793303T AT E550343 T1 ATE550343 T1 AT E550343T1
Authority
AT
Austria
Prior art keywords
gemcitabine
synthesis
naphthaline
production
carboxylate derivative
Prior art date
Application number
AT07793303T
Other languages
English (en)
Inventor
Kyu Wann Kim
Kyoung Soo Kim
Young Won Park
Young Jun Park
Won Kyoung Lee
Original Assignee
Yuil Pharm Tech Co Ltd
Chiro Genix Co Ltd
Kyu Wann Kim
Kyoung Soo Kim
Young Won Park
Young Jun Park
Won Kyoung Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuil Pharm Tech Co Ltd, Chiro Genix Co Ltd, Kyu Wann Kim, Kyoung Soo Kim, Young Won Park, Young Jun Park, Won Kyoung Lee filed Critical Yuil Pharm Tech Co Ltd
Application granted granted Critical
Publication of ATE550343T1 publication Critical patent/ATE550343T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
AT07793303T 2006-08-01 2007-07-30 Für die synthese von gemcitabin geeignetes naphthalin-2-carboxylatderivat und verfahren zu dessen herstellung ATE550343T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020060072786A KR100741310B1 (ko) 2006-08-01 2006-08-01 젬시타빈의 합성에 유용한 신규한나프탈렌-2-카르복실레이트 유도체와 그의 제조방법
PCT/KR2007/003648 WO2008016244A1 (en) 2006-08-01 2007-07-30 Naphthalene 2-carboxylate derivative useful for synthesizing gemcitabine and a method for preparing the same

Publications (1)

Publication Number Publication Date
ATE550343T1 true ATE550343T1 (de) 2012-04-15

Family

ID=38601320

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07793303T ATE550343T1 (de) 2006-08-01 2007-07-30 Für die synthese von gemcitabin geeignetes naphthalin-2-carboxylatderivat und verfahren zu dessen herstellung

Country Status (7)

Country Link
US (1) US20100010205A1 (de)
EP (1) EP2049558B8 (de)
JP (1) JP4528884B2 (de)
KR (1) KR100741310B1 (de)
CN (1) CN101495496A (de)
AT (1) ATE550343T1 (de)
WO (1) WO2008016244A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2139884B1 (de) * 2007-03-23 2013-12-04 Dongwoo Syntech Co., Ltd. Verfahren zur herstellung von 2'-desoxy-2',2'-difluorcytidin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1254212A (en) * 1982-11-12 1989-05-16 Shiro Hirai Amine derivatives, salts thereof, process for preparing the same and an anti-ulcer agent containing the same
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
ATE179713T1 (de) * 1987-08-28 1999-05-15 Lilly Co Eli Verfahren zur selektiven isolierung von beta-2'- desoxy-2'2'-difluorocytidin oder seiner salze
US6001994A (en) * 1995-12-13 1999-12-14 Eli Lilly And Company Process for making gemcitabine hydrochloride
US6013790A (en) * 1996-09-25 2000-01-11 Board Of Regents University Of Nebraska-Lincoln Heavily fluorinated sugar analogs
AU2003291726A1 (en) * 2002-11-04 2004-06-07 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
KR100578616B1 (ko) * 2004-07-23 2006-05-10 한미약품 주식회사 Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
JP2009506118A (ja) * 2005-08-29 2009-02-12 ケマジス・リミテッド ゲムシタビンおよび関連中間体の製造方法

Also Published As

Publication number Publication date
CN101495496A (zh) 2009-07-29
EP2049558A1 (de) 2009-04-22
KR100741310B1 (ko) 2007-08-01
JP2009545586A (ja) 2009-12-24
EP2049558B8 (de) 2012-08-01
US20100010205A1 (en) 2010-01-14
EP2049558A4 (de) 2009-12-30
JP4528884B2 (ja) 2010-08-25
WO2008016244A1 (en) 2008-02-07
EP2049558B1 (de) 2012-03-21

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