ATE549921T1 - Radioaktiv markierte glycintransporter-hemmer - Google Patents
Radioaktiv markierte glycintransporter-hemmerInfo
- Publication number
- ATE549921T1 ATE549921T1 AT06815187T AT06815187T ATE549921T1 AT E549921 T1 ATE549921 T1 AT E549921T1 AT 06815187 T AT06815187 T AT 06815187T AT 06815187 T AT06815187 T AT 06815187T AT E549921 T1 ATE549921 T1 AT E549921T1
- Authority
- AT
- Austria
- Prior art keywords
- transporter inhibitors
- glycine transporter
- radioactive labeled
- labeled glycine
- radioactive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72178205P | 2005-09-29 | 2005-09-29 | |
| PCT/US2006/036989 WO2007041025A2 (en) | 2005-09-29 | 2006-09-25 | Radiolabeled glycine transporter inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE549921T1 true ATE549921T1 (de) | 2012-04-15 |
Family
ID=37906660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06815187T ATE549921T1 (de) | 2005-09-29 | 2006-09-25 | Radioaktiv markierte glycintransporter-hemmer |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7834031B2 (de) |
| EP (1) | EP1942733B1 (de) |
| AT (1) | ATE549921T1 (de) |
| ES (1) | ES2382818T3 (de) |
| WO (1) | WO2007041025A2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE488501T1 (de) | 2004-09-30 | 2010-12-15 | Merck Sharp & Dohme | Cyclopropylpiperidinglycin-transporter-inhibito |
| BRPI0921795B8 (pt) * | 2008-11-04 | 2021-07-27 | Hoffmann La Roche | inibidores radiomarcados do transportador de glicina 1 e seu uso |
| US8431700B2 (en) | 2009-03-03 | 2013-04-30 | Vanderbilt University | Alkylsulfonyl-2,3-dihydrospiro[indene-1,4′-piperidine] analogs as GlyT1 inhibitors, methods for making same, and use of same in treating psychiatric disorders |
| BRPI1006398A2 (pt) * | 2009-03-19 | 2019-09-24 | Koninl Philips Electronics Nv | método e sistema |
| JP5618047B2 (ja) * | 2010-01-29 | 2014-11-05 | 国立大学法人千葉大学 | ポジトロン断層撮影法およびポジトロン放出化合物 |
| CA2801074A1 (en) * | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| WO2012168175A1 (en) | 2011-06-07 | 2012-12-13 | F. Hoffmann-La Roche Ag | [1,3]oxazines |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4931270A (en) | 1988-07-07 | 1990-06-05 | Nelson Research & Development | Method for detecting dopaminergic diseases using fluorine-18 radiolabelled D2 dopamine receptor ligands |
| EP1844769A3 (de) | 1998-04-14 | 2010-02-10 | The General Hospital Corporation | Verfahren zur Behandlung neuropsychischer Erkrankungen |
| ATE439838T1 (de) * | 1998-09-29 | 2009-09-15 | Merck & Co Inc | Radiomarkierte neurokinin-1 rezeptor antagonisten |
| US6303637B1 (en) * | 1998-10-30 | 2001-10-16 | Merck & Co., Inc. | Heterocyclic potassium channel inhibitors |
| US6458935B1 (en) * | 1999-06-23 | 2002-10-01 | Merck & Co., Inc. | Radiolabeled farnesyl-protein transferase inhibitors |
| JP4554202B2 (ja) * | 2001-07-24 | 2010-09-29 | メルク・シャープ・エンド・ドーム・コーポレイション | 放射性標識神経ペプチドｙｙ５受容体拮抗薬 |
| ES2354151T3 (es) * | 2002-09-24 | 2011-03-10 | MERCK SHARP & DOHME CORP. | Antagonistas del receptor de neuroquinina-1 radiomarcados. |
| CN1878551A (zh) * | 2003-11-12 | 2006-12-13 | 默克公司 | 4－苯基哌啶磺酰基甘氨酸转运体抑制剂 |
| CA2560256C (en) | 2004-03-24 | 2013-02-19 | Merck & Co., Inc. | Heteroaryl piperidine glycine transporter inhibitors |
-
2006
- 2006-09-25 WO PCT/US2006/036989 patent/WO2007041025A2/en active Application Filing
- 2006-09-25 US US11/991,727 patent/US7834031B2/en active Active
- 2006-09-25 ES ES06815187T patent/ES2382818T3/es active Active
- 2006-09-25 EP EP06815187A patent/EP1942733B1/de active Active
- 2006-09-25 AT AT06815187T patent/ATE549921T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2382818T3 (es) | 2012-06-13 |
| US20090269278A1 (en) | 2009-10-29 |
| EP1942733A2 (de) | 2008-07-16 |
| WO2007041025A3 (en) | 2007-08-30 |
| EP1942733A4 (de) | 2010-11-10 |
| EP1942733B1 (de) | 2012-03-21 |
| WO2007041025A2 (en) | 2007-04-12 |
| US7834031B2 (en) | 2010-11-16 |
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