ATE549309T1 - Polyisoprevonl benzophenone als inhibitoren von histonacetyltransdferasen und anwendungen dafür - Google Patents
Polyisoprevonl benzophenone als inhibitoren von histonacetyltransdferasen und anwendungen dafürInfo
- Publication number
- ATE549309T1 ATE549309T1 AT04799059T AT04799059T ATE549309T1 AT E549309 T1 ATE549309 T1 AT E549309T1 AT 04799059 T AT04799059 T AT 04799059T AT 04799059 T AT04799059 T AT 04799059T AT E549309 T1 ATE549309 T1 AT E549309T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- inhibitors
- pcaf
- histone
- mum
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 239000012965 benzophenone Substances 0.000 title abstract 3
- 108010033040 Histones Proteins 0.000 title 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 title 1
- 102100038885 Histone acetyltransferase p300 Human genes 0.000 abstract 3
- 102100022846 Histone acetyltransferase KAT2B Human genes 0.000 abstract 2
- 101001047006 Homo sapiens Histone acetyltransferase KAT2B Proteins 0.000 abstract 2
- 150000008366 benzophenones Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 108010077544 Chromatin Proteins 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 241000593508 Garcinia Species 0.000 abstract 1
- 101710155878 Histone acetyltransferase p300 Proteins 0.000 abstract 1
- 101100341791 Mus musculus Kat2b gene Proteins 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 230000003915 cell function Effects 0.000 abstract 1
- 150000005829 chemical entities Chemical class 0.000 abstract 1
- 210000003483 chromatin Anatomy 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 230000000464 effect on transcription Effects 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN929CH2003 IN2003CH00929A (enExample) | 2003-11-13 | 2003-11-13 | |
| PCT/IB2004/052294 WO2005047457A2 (en) | 2003-11-13 | 2004-11-04 | Polyisoprenyl benzophenones as inhibitors of histone acetyl transferases and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE549309T1 true ATE549309T1 (de) | 2012-03-15 |
Family
ID=34586954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04799059T ATE549309T1 (de) | 2003-11-13 | 2004-11-04 | Polyisoprevonl benzophenone als inhibitoren von histonacetyltransdferasen und anwendungen dafür |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7402706B2 (enExample) |
| EP (1) | EP1694622B1 (enExample) |
| AT (1) | ATE549309T1 (enExample) |
| IN (1) | IN2003CH00929A (enExample) |
| WO (1) | WO2005047457A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2006520796A (ja) | 2003-03-17 | 2006-09-14 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼインヒビター |
| WO2006066133A2 (en) | 2004-12-16 | 2006-06-22 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7642253B2 (en) | 2005-05-11 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| KR20080032188A (ko) | 2005-07-14 | 2008-04-14 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
| AR057579A1 (es) * | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| KR101005173B1 (ko) * | 2008-02-18 | 2011-01-04 | 인제대학교 산학협력단 | 항산화 및 세포독성 활성을 나타내는 물레나물과의가르시니아 오블롱기폴리아로부터 추출된 분획물 및그로부터 분리된 화합물 |
| WO2011027330A1 (en) * | 2009-09-07 | 2011-03-10 | Jawaharlal Nehru Centre For Advanced Scientific Research | Inhibition of histone acetyltransferases by ctk7a and methods thereof |
| CA2820984C (en) * | 2010-12-09 | 2016-10-11 | Indus Biotech Private Limited | A complex of garcinol, cyclodextrin and method thereof |
| WO2013148114A1 (en) * | 2012-03-30 | 2013-10-03 | University Of Florida Research Foundation, Inc. | P300/cbp inhibitors and methods of use |
| GB201215942D0 (en) * | 2012-09-06 | 2012-10-24 | Glaxo Group Ltd | Method of treatent |
| KR20200011492A (ko) * | 2017-06-22 | 2020-02-03 | 새미 랩스 리미티드 | 소포체 스트레스의 치료학적 관리를 위한 가르시놀 조성물 |
| TWI846350B (zh) | 2017-09-15 | 2024-06-21 | 美商佛瑪治療公司 | 作為ＣＢＰ／ｐ３００抑制劑之四氫－咪唑並喹啉化合物 |
| MX2023013508A (es) | 2018-06-29 | 2023-12-13 | Forma Therapeutics Inc | Inhibicion de la proteina de union a creb (cbp). |
| US12351577B2 (en) | 2019-03-15 | 2025-07-08 | Forma Therapeutics, Inc. | Inhibiting cyclic AMP-responsive element-binding protein (CREB) |
| US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
| US11795168B2 (en) | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
| US20240269106A1 (en) * | 2021-06-02 | 2024-08-15 | Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn | Small molecule modulator targeting a rare histone modification regulating adipogenesis and pharmaceutical formulation thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08259493A (ja) * | 1995-03-20 | 1996-10-08 | Sugimoto Masami | 抗ｍｒｓａ活性物質 |
-
2003
- 2003-11-13 IN IN929CH2003 patent/IN2003CH00929A/en unknown
-
2004
- 2004-11-04 EP EP04799059A patent/EP1694622B1/en not_active Expired - Lifetime
- 2004-11-04 AT AT04799059T patent/ATE549309T1/de active
- 2004-11-04 US US10/579,219 patent/US7402706B2/en not_active Expired - Fee Related
- 2004-11-04 WO PCT/IB2004/052294 patent/WO2005047457A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US7402706B2 (en) | 2008-07-22 |
| WO2005047457A3 (en) | 2005-08-04 |
| IN2003CH00929A (enExample) | 2008-10-06 |
| US20070254961A1 (en) | 2007-11-01 |
| WO2005047457B1 (en) | 2005-12-01 |
| EP1694622B1 (en) | 2012-03-14 |
| WO2005047457A2 (en) | 2005-05-26 |
| EP1694622A2 (en) | 2006-08-30 |
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