ATE533478T1 - Missbrauchssichere opioide mit transdermalen systemen - Google Patents

Missbrauchssichere opioide mit transdermalen systemen

Info

Publication number
ATE533478T1
ATE533478T1 AT08020810T AT08020810T ATE533478T1 AT E533478 T1 ATE533478 T1 AT E533478T1 AT 08020810 T AT08020810 T AT 08020810T AT 08020810 T AT08020810 T AT 08020810T AT E533478 T1 ATE533478 T1 AT E533478T1
Authority
AT
Austria
Prior art keywords
opioids
abuse
proof
transdermal systems
dosage form
Prior art date
Application number
AT08020810T
Other languages
English (en)
Inventor
Lino Tavares
Bruce E Reidenberg
Richard S Sackler
Curtis Wright
Mark A Alfonso
Benjamin Oshlack
James P Cassidy
Anthony E Carpanzano
Rampurna Prasad Gullapalli
Ihor Shevchuk
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE533478T1 publication Critical patent/ATE533478T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
    • B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
    • B09B2101/00—Type of solid waste
    • B09B2101/65—Medical waste
    • B09B2101/68—Transdermal patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT08020810T 2001-05-01 2002-04-30 Missbrauchssichere opioide mit transdermalen systemen ATE533478T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28787501P 2001-05-01 2001-05-01
US29253701P 2001-05-22 2001-05-22

Publications (1)

Publication Number Publication Date
ATE533478T1 true ATE533478T1 (de) 2011-12-15

Family

ID=26964697

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02731653T ATE415952T1 (de) 2001-05-01 2002-04-30 Vor missbrauch geschützte opioid-haltige transdermale systeme
AT08020810T ATE533478T1 (de) 2001-05-01 2002-04-30 Missbrauchssichere opioide mit transdermalen systemen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT02731653T ATE415952T1 (de) 2001-05-01 2002-04-30 Vor missbrauch geschützte opioid-haltige transdermale systeme

Country Status (11)

Country Link
US (2) US20040241218A1 (de)
EP (3) EP2062573B1 (de)
JP (3) JP5296284B2 (de)
AT (2) ATE415952T1 (de)
CY (2) CY1108821T1 (de)
DE (1) DE60230138D1 (de)
DK (3) DK1397095T3 (de)
ES (3) ES2377672T3 (de)
PT (3) PT1397095E (de)
SI (3) SI2316439T1 (de)
WO (1) WO2002087482A1 (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
AU2002339378A1 (en) 2001-05-22 2002-12-03 Euro-Celtique Compartmentalized dosage form
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
WO2003090729A1 (en) * 2002-04-23 2003-11-06 Alza Corporation Transdermal analgesic systems with reduced abuse potential
NZ537180A (en) * 2002-06-10 2008-03-28 Euro Celtique Sa Disposal systems of transdermal delivery devices to prevent misuse of the active agents contained therein
SI1551372T1 (en) 2002-09-20 2018-08-31 Alpharma Pharmaceuticals Llc SUBVENCATION DATA AND RELATED CONSTRUCTIONS AND PROCEDURES
DE10250088A1 (de) * 2002-10-25 2004-05-06 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US7182955B2 (en) * 2003-04-30 2007-02-27 3M Innovative Properties Company Abuse-resistant transdermal dosage form
US20040219195A1 (en) * 2003-04-30 2004-11-04 3M Innovative Properties Company Abuse-resistant transdermal dosage form
AU2004235794B8 (en) * 2003-04-30 2009-07-23 Purdue Pharma L.P. Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer
US8790689B2 (en) * 2003-04-30 2014-07-29 Purdue Pharma L.P. Tamper resistant transdermal dosage form
KR20120128715A (ko) * 2003-07-25 2012-11-27 유로-셀티큐 에스.에이. 수술후 통증의 수술전 치료
CN1909892A (zh) * 2003-10-30 2007-02-07 阿尔扎公司 具有降低的滥用可能性的透皮止痛剂系统
US7867511B2 (en) 2004-01-23 2011-01-11 Travanti Pharma Inc. Abuse potential reduction in abusable substance dosage form
US8535711B2 (en) * 2004-01-23 2013-09-17 Teikoku Pharma Usa, Inc. Medication disposal system
PT2351555T (pt) * 2004-02-23 2016-11-29 Euro Celtique Sa Dispositivo para a administração transdérmica de opióides resistente ao abuso
CN101005833A (zh) * 2004-08-20 2007-07-25 3M创新有限公司 具有半透明保护膜的透皮药物递送装置
US7226619B1 (en) 2004-09-07 2007-06-05 Pharmorx Inc. Material for controlling diversion of medications
AU2005284908B2 (en) 2004-09-13 2011-12-08 Morningside Venture Investments Limited Biosynchronous transdermal drug delivery
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
EP1814531B1 (de) * 2004-10-21 2010-06-16 Durect Corporation Transdermale verabreichungssysteme
WO2006069008A1 (en) * 2004-12-22 2006-06-29 Vesta Medical, Llc Compositions and devices for inactivation of pharmaceuticals to facilitate waste disposal, and methods thereof
US20060182819A1 (en) 2005-02-17 2006-08-17 Ough Yon D Soap scent patch and treatment for muscle spasm and pain
TW200640526A (en) * 2005-02-24 2006-12-01 Alza Corp Transdermal electrotransport drug delivery systems with reduced abuse potential
DE602006016441D1 (de) 2005-05-13 2010-10-07 Alza Corp Mehrlagiges arzneimittelausbringsystem mit sperre gegen reservoirmaterialfluss
US20060257460A1 (en) * 2005-05-13 2006-11-16 Jansen Rolf R Multilayer drug delivery system with barrier against antagonist exposure
US20070014839A1 (en) * 2005-07-18 2007-01-18 Stefan Bracht Decomposer film for transdermal patches
WO2007035940A2 (en) 2005-09-23 2007-03-29 Alza Corporation Transdermal norelgestromin delivery system
WO2007035939A2 (en) 2005-09-23 2007-03-29 Alza Corporation High enhancer-loading polyacrylate formulation for transdermal applications
AU2006326377B2 (en) * 2005-12-13 2010-10-07 Biodelivery Sciences International, Inc. Abuse resistant transmucosal drug delivery device
DE102006025282A1 (de) * 2006-05-31 2007-12-20 Lts Lohmann Therapie-Systeme Ag Selbstzerstörendes transdermales therapeutisches System
EP2719378B1 (de) 2006-06-19 2016-08-31 Alpharma Pharmaceuticals LLC Pharmazeutische Zusammensetzungen
US20080008747A1 (en) * 2006-07-07 2008-01-10 Royds Robert B Transdermal patch
SI2054031T1 (sl) 2006-07-21 2016-09-30 Biodelivery Sciences International, Inc. Transmukozne naprave za administracijo z izboljšanim vnosom
AU2007322269A1 (en) * 2006-10-11 2008-05-29 Alpharma Pharmaceuticals, Llc Pharmaceutical compositions
US20080286348A1 (en) * 2007-05-16 2008-11-20 Todhunter John A Secured transdermal delivery system
DE102007041557B4 (de) * 2007-08-29 2011-03-31 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System enthaltend längliche Hohlkörper
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
CA2709905A1 (en) * 2007-12-17 2009-06-25 Alfred Liang Abuse-resistant oxycodone composition
JP2011515495A (ja) * 2008-03-26 2011-05-19 オールトランツ インコーポレイティド オピエートアゴニスト及びアゴニスト−アンタゴニストの乱用抑制経皮製剤
DE102008016804B4 (de) 2008-04-02 2012-01-05 Lts Lohmann Therapie-Systeme Ag Selbstzerstörendes transdermales therapeutisches System mit verbesserter Funktionalität und Wirksamkeit sowie seine Verwendung
JP2013523780A (ja) * 2010-04-02 2013-06-17 オールトランツ インコーポレイティド オピエートアゴニスト及びアゴニスト−アンタゴニストの乱用抑止性経皮製剤
EP2729148A4 (de) 2011-07-06 2015-04-22 Parkinson S Inst Zusammensetzungen und verfahren zur behandlung von symptomen bei patienten mit morbus parkinson
SG10201610097WA (en) 2011-08-18 2017-01-27 Biodelivery Sciences Int Inc Abuse-resistant mucoadhesive devices for delivery of buprenorphine
CN103764129A (zh) 2011-09-30 2014-04-30 帝国制药美国公司 透皮贴剂处置系统
CN103764092A (zh) 2011-09-30 2014-04-30 帝国制药美国公司 普通药物处置系统
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
US9623017B2 (en) 2014-09-24 2017-04-18 Pain Therapeutics, Inc. 4:3 naltrexone: 5-methyl-2-furaldehyde cocrystal
US10010543B1 (en) 2014-12-23 2018-07-03 Barr Laboratories, Inc. Transdermal dosage form
JP2018511355A (ja) 2015-01-28 2018-04-26 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 薬剤送達方法及びシステム
JP2018511127A (ja) 2015-03-12 2018-04-19 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 渇望入力及び支援システム
JP7261586B2 (ja) * 2016-02-26 2023-04-20 ケース ウェスタン リザーブ ユニバーシティ フロー電池用複合膜
EP3565617A1 (de) 2017-01-06 2019-11-13 Chrono Therapeutics Inc. Vorrichtungen und verfahren zur transdermalen wirkstofffreisetzung
US11389844B2 (en) 2018-03-20 2022-07-19 Verde Environmental Technologies, Inc. Blister pack disposal system
AU2019279884B2 (en) 2018-05-29 2025-01-30 Morningside Venture Investments Limited Drug delivery methods and systems
WO2020009685A1 (en) * 2018-07-02 2020-01-09 John Tang Transdermal dosage form
WO2020008366A1 (en) * 2018-07-02 2020-01-09 Clexio Biosciences Ltd. Transdermal dosage form
EP3870262A1 (de) * 2018-10-23 2021-09-01 Kindeva Drug Delivery L.P. Manipulationssicheres transdermales pflaster
CA3119992A1 (en) 2018-11-16 2020-05-22 Morningside Venture Investments Limited Thermally regulated transdermal drug delivery system
WO2021028916A1 (en) * 2019-08-12 2021-02-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Pharmaceutical compositions comprising a combination of opioid antagonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3643987A1 (de) * 1986-12-22 1988-06-23 Lohmann Therapie Syst Lts Basische, wirkstoffdurchlaessige haftklebende polymermasse, insbesondere zum einsatz mit basischen wirkstoffen, verfahren zu ihrer herstellung und ihre verwendung
US5236714A (en) * 1988-11-01 1993-08-17 Alza Corporation Abusable substance dosage form having reduced abuse potential
US5028435A (en) * 1989-05-22 1991-07-02 Advanced Polymer Systems, Inc. System and method for transdermal drug delivery
US5149538A (en) 1991-06-14 1992-09-22 Warner-Lambert Company Misuse-resistive transdermal opioid dosage form
US6096756A (en) * 1992-09-21 2000-08-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
US5573778A (en) * 1995-03-17 1996-11-12 Adhesives Research, Inc. Drug flux enhancer-tolerant pressure sensitive adhesive composition
AU6657396A (en) * 1995-07-28 1997-02-26 Novartis Ag Transdermal system
US7011843B2 (en) * 1997-10-01 2006-03-14 Lts Lohmann-Therapie Systeme Ag Method for protecting a human being against health impairment by ingestion of a transdermal therapeutic system
BR9813826A (pt) * 1997-12-22 2000-10-10 Euro Celtique Sa Potencial de uso abusivo de administração oral de opióide analgésico
US6554851B1 (en) * 1999-05-07 2003-04-29 Scimed Life Systems, Inc. Methods of sealing an injection site
WO2002085268A1 (en) * 2001-04-23 2002-10-31 Euro-Celtique S.A. Disposal system for transdermal dosage form

Also Published As

Publication number Publication date
PT2316439E (pt) 2015-08-28
ES2377672T3 (es) 2012-03-29
JP2013144702A (ja) 2013-07-25
EP1397095A4 (de) 2005-05-25
US20140199383A1 (en) 2014-07-17
ATE415952T1 (de) 2008-12-15
ES2546828T3 (es) 2015-09-29
CY1108821T1 (el) 2014-04-09
DE60230138D1 (de) 2009-01-15
DK1397095T3 (da) 2009-03-09
EP1397095B1 (de) 2008-12-03
JP2004529155A (ja) 2004-09-24
ES2318010T3 (es) 2009-05-01
SI2316439T1 (sl) 2015-10-30
EP2316439A1 (de) 2011-05-04
JP5296284B2 (ja) 2013-09-25
JP2015042649A (ja) 2015-03-05
EP2316439B1 (de) 2015-06-17
WO2002087482A1 (en) 2002-11-07
EP2062573B1 (de) 2011-11-16
CY1112271T1 (el) 2015-12-09
EP1397095A1 (de) 2004-03-17
DK2062573T3 (da) 2012-01-30
DK2316439T3 (en) 2015-08-10
SI1397095T1 (sl) 2009-04-30
SI2062573T1 (sl) 2012-02-29
US20040241218A1 (en) 2004-12-02
PT2062573E (pt) 2012-01-11
EP2062573A1 (de) 2009-05-27
PT1397095E (pt) 2009-02-17

Similar Documents

Publication Publication Date Title
ATE533478T1 (de) Missbrauchssichere opioide mit transdermalen systemen
DE60143360D1 (de) Zusammensetzung zur transdermalen und/oder transmukosalen Verabreichung von Wirkstoffen, die ausreichende therapeutische Spiegel garantiert
DK0782855T3 (da) Nimesulid til ekstern anvendelse
DK0759747T3 (da) Transdermal indretning til administration gennem de-epitheliseret hud
BR0308090A (pt) conjugados de agentes citotóxicos ou terapêuticos e peptìdios biologicamente ativos
EA200600696A1 (ru) Фармацевтические композиции для предотвращения передозировки или неправильного употребления лекарственных средств
ATE280594T1 (de) Wundauflage
SE9904377D0 (sv) Pharmaceutical combinations
CY1108835T1 (el) Θεραπευτικες χρησεις αγωνιστων και ανταγωνιστων της il174
BR9807523A (pt) Quinoxalinas em combinação tripla com inibidores da protease e inibidores de transcriptase reversa como medicamentos para o tratamento de aids.
TR199802351T2 (xx) Topikal kullanım için bir veya birden fazla lokal anestezik ve anti-vajinit maddeler ihtiva eden anti-vajinit bileşimi.
WO2003063725A3 (en) Methods of preventing and treating flavivirus infection in animals
EE200300213A (et) SARP-1 kasutamine sklerodermia raviks ja/või ennetamiseks
SE0103276D0 (sv) Anordning för administrering av salva till en hudyta
ATE399558T1 (de) Anti-tumorale formulierungen mit defibrotid allein oder in kombination mit anderen antitumoralen mitteln
DE60110087D1 (de) Verwendung von Carboanhydrase-Inhibitoren zur Prävention von diabetischer Retinopathie bei Diabetikern
TR200002939T2 (tr) Paroksetin maleat
DK1052991T3 (da) Topisk anvendelse af loperamid til behandling af mikrobielle infektioner
DE60034770D1 (de) Stabile fumagillin-formulierung
BR0211533A (pt) Tratamento de dor crÈnica com 3-heterociclil- e 3-cicloalquil-3-ariloxipropanaminas
CY1116853T1 (el) Διαδερμικα συστηματα οπιοειδων περισταλτικα της απροσφορης χρησης
WO2002002089A3 (de) Anthelminthika zur verhinderung von parasitären infektionen bei mensch und tier iv
TR200400812T3 (tr) KanserÁtedavisiÁiçinÁretinoidÁreseptörÁligandlarınınÁveÁseçilenÁsitotoksikÁmaddelerinÁsinerjistikÁkombinasyonları
UA33424A (uk) Пристрій для профілактики та лікування постмастектомічного синдрому