ATE528408T1 - Selektivitätsprofilerstellung von mit pi3k wechselwirkenden molekülen gegen mehrere ziele - Google Patents

Selektivitätsprofilerstellung von mit pi3k wechselwirkenden molekülen gegen mehrere ziele

Info

Publication number
ATE528408T1
ATE528408T1 AT09709335T AT09709335T ATE528408T1 AT E528408 T1 ATE528408 T1 AT E528408T1 AT 09709335 T AT09709335 T AT 09709335T AT 09709335 T AT09709335 T AT 09709335T AT E528408 T1 ATE528408 T1 AT E528408T1
Authority
AT
Austria
Prior art keywords
multiple target
against multiple
interacting molecules
molecules against
pi3k
Prior art date
Application number
AT09709335T
Other languages
English (en)
Inventor
Andrew David Cansfield
Moore Giovanna Bergamini
Gitte Neubauer
Original Assignee
Cellzome Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ag filed Critical Cellzome Ag
Application granted granted Critical
Publication of ATE528408T1 publication Critical patent/ATE528408T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT09709335T 2008-02-04 2009-02-03 Selektivitätsprofilerstellung von mit pi3k wechselwirkenden molekülen gegen mehrere ziele ATE528408T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08002053 2008-02-04
PCT/EP2009/000692 WO2009098021A1 (en) 2008-02-04 2009-02-03 Selectivity profiling of pi3k interacting molecules against multiple targets

Publications (1)

Publication Number Publication Date
ATE528408T1 true ATE528408T1 (de) 2011-10-15

Family

ID=39561994

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09709335T ATE528408T1 (de) 2008-02-04 2009-02-03 Selektivitätsprofilerstellung von mit pi3k wechselwirkenden molekülen gegen mehrere ziele

Country Status (10)

Country Link
US (1) US20110111972A1 (de)
EP (2) EP2410062A1 (de)
JP (1) JP2011514965A (de)
CN (1) CN101965408B (de)
AT (1) ATE528408T1 (de)
AU (1) AU2009211845A1 (de)
CA (1) CA2713276A1 (de)
DK (1) DK2245181T3 (de)
ES (1) ES2375541T3 (de)
WO (1) WO2009098021A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE414281T1 (de) 2006-08-03 2008-11-15 Cellzome Ag Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3k
EP2406258B1 (de) 2009-03-13 2014-12-03 Cellzome Limited Pyrimidin-derivate als mtor-hemmer
EP2542536B1 (de) 2010-03-04 2015-01-21 Cellzome Limited Morpholinsubstituierte Harnstoff-Derivate als mTOR-Hemmer
US20130210030A1 (en) 2010-07-19 2013-08-15 Cellzome Ag In vivo method for the evaluation of a compound-target interaction
WO2012136622A1 (en) 2011-04-04 2012-10-11 Cellzome Limited Dihydropyrrolo pyrimidine derivatives as mtor inhibitors
CA2849189A1 (en) 2011-09-21 2013-03-28 Cellzome Limited Morpholino substituted urea or carbamate derivatives as mtor inhibitors
JP5995977B2 (ja) 2011-10-07 2016-09-21 セルゾーム リミテッド Ｍｔｏｒ阻害剤としてのモルホリノ置換二環式ピリミジン尿素またはカルバメート誘導体
CN102977063A (zh) * 2012-11-26 2013-03-20 盛世泰科生物医药技术(苏州)有限公司 一种2-吗啡啉-8-苯基-4-苯并吡喃-4-酮的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525503A (en) * 1993-09-28 1996-06-11 Dana-Farber Cancer Institute, Inc. Signal transduction via CD28
US20030194749A1 (en) * 2002-02-15 2003-10-16 Wandless Thomas J. Wortmannin derivatives as probes of cellular proteins and processes
AR038703A1 (es) 2002-02-28 2005-01-26 Novartis Ag Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3
SE0402735D0 (sv) * 2004-11-09 2004-11-09 Astrazeneca Ab Novel compounds
EP1734367A1 (de) * 2005-06-14 2006-12-20 Cellzome Ag Verfahren zum Auffinden von neuen Verbindungen, die mit einem Enzym in Wechselwirkung treten
WO2006134056A1 (en) 2005-06-14 2006-12-21 Cellzome Ag Process for the identification of novel enzyme interacting compounds
JP2009507072A (ja) * 2005-09-07 2009-02-19 ラボラトワール セローノ ソシエテ アノニム 子宮内膜症の処置のためのｐｉ３ｋ阻害剤
ATE431426T1 (de) * 2006-03-14 2009-05-15 Cellzome Ag Verfahren zur identifizierung von lrrk2 interagierenden molekülen und zur reinigung von lrrk2
ATE414281T1 (de) * 2006-08-03 2008-11-15 Cellzome Ag Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3k

Also Published As

Publication number Publication date
CN101965408A (zh) 2011-02-02
AU2009211845A1 (en) 2009-08-13
EP2245181A1 (de) 2010-11-03
ES2375541T3 (es) 2012-03-01
HK1144705A1 (en) 2011-03-04
DK2245181T3 (da) 2012-02-06
EP2410062A1 (de) 2012-01-25
JP2011514965A (ja) 2011-05-12
CN101965408B (zh) 2013-08-28
CA2713276A1 (en) 2009-08-13
WO2009098021A1 (en) 2009-08-13
EP2245181B1 (de) 2011-10-12
US20110111972A1 (en) 2011-05-12

Similar Documents

Publication Publication Date Title
DK2245181T3 (da) Selektivitetsprofilering af PI3K-interagerende molekyler med multiple mål
EA201170124A1 (ru) Полихромные вещества и их применение
EA200702670A1 (ru) Препарат тиенопиридинового ингибитора агрегации тромбоцитов
MA37940A2 (fr) Nouveaux dérivés bicycliques
UA110338C2 (xx) Хімічні сполуки
EA200970402A1 (ru) Триазолопиридазиновые модуляторы протеинкиназ
BRPI1009637A2 (pt) composto, composição e uso de um composto
LT2889043T (lt) Sintetiniai tarpiniai junginiai oligosacharido-baltymo konjugatų gamybai
SMAP201100019A (it) Composti organici.
BR112013026324A2 (pt) compostos de benzeno substituídos com arila ou heteroarila
CO6852084A2 (es) Nuevos compuestos sustituidos con halógeno
EA201500173A1 (ru) Фунгицидные композиции
PL2342196T3 (pl) Związki pirazolowe do zwalczania szkodników będących bezkręgowcami
CY1111793T1 (el) Μυκητοκτονες συνθεσεις
CO6640320A2 (es) Composición de control de fitoenfermedades y metodo de control de fitoenfermedades
EA201101669A1 (ru) Новая соль базедоксифена
ATE511845T1 (de) Verwendung von isothicyanat-derviaten als myelom- bekämpfende wirkstoffe
EA201590979A1 (ru) Способы и промежуточные химические соединения для получения фармацевтических средств
ATE539054T1 (de) Verfahren zur herstellung von dihydropyrrolderivaten als zwischenprodukte
CO6310993A2 (es) Moleculas utiles para el control de insectos
CR11463A (es) Compuestos de piridilmetil-sulfonamida
CY1111691T1 (el) Ενισχυτης της δραστικοτητας πρωτεϊνοκινασης c περιεχων παραγωγο αλκυλαιθερος ή αλας αυτου
EA200900090A1 (ru) Бензиламины, способ их получения и их применение в качестве противовоспалительных средств
DOP2009000088A (es) Pirazoles sustituidos que presentan actividad anticancerígena
EP2890379A4 (de) Benzothiazol- oder benzoxazolderivate als sumo-aktivatoren

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 2245181

Country of ref document: EP