ATE518913T1 - Verfahren zur gezielten markierung mittels affinitätsmarkierter detektionsmarker - Google Patents
Verfahren zur gezielten markierung mittels affinitätsmarkierter detektionsmarkerInfo
- Publication number
- ATE518913T1 ATE518913T1 AT05000174T AT05000174T ATE518913T1 AT E518913 T1 ATE518913 T1 AT E518913T1 AT 05000174 T AT05000174 T AT 05000174T AT 05000174 T AT05000174 T AT 05000174T AT E518913 T1 ATE518913 T1 AT E518913T1
- Authority
- AT
- Austria
- Prior art keywords
- reactive group
- test material
- binding
- marking
- contain
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- 239000000463 material Substances 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 cyano, carbonyl Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- ZOQBMQREQNVKHB-UHFFFAOYSA-N 2-(azidodisulfanyl)-5-(1-methylpyrrolidin-2-yl)pyridine Chemical class N(=[N+]=[N-])SSC1=NC=C(C=C1)C1N(C)CCC1 ZOQBMQREQNVKHB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001810 isothiocyanato group Chemical group *N=C=S 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B19/00—Oxazine dyes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Flanged Joints, Insulating Joints, And Other Joints (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00119292 | 2000-09-06 | ||
| EP00127005A EP1213328A1 (de) | 2000-12-08 | 2000-12-08 | Oxazinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE518913T1 true ATE518913T1 (de) | 2011-08-15 |
Family
ID=26071369
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05000174T ATE518913T1 (de) | 2000-09-06 | 2001-09-05 | Verfahren zur gezielten markierung mittels affinitätsmarkierter detektionsmarker |
| AT01978341T ATE287430T1 (de) | 2000-09-06 | 2001-09-05 | Oxazinderivate |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01978341T ATE287430T1 (de) | 2000-09-06 | 2001-09-05 | Oxazinderivate |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7101999B2 (Direct) |
| EP (2) | EP1317511B1 (Direct) |
| JP (1) | JP2004508448A (Direct) |
| AT (2) | ATE518913T1 (Direct) |
| DE (1) | DE50105139D1 (Direct) |
| WO (1) | WO2002020670A1 (Direct) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7101999B2 (en) | 2000-09-06 | 2006-09-05 | Evotec Ag | Oxazine derivatives |
| DE10212960A1 (de) * | 2002-03-22 | 2003-10-23 | Gnothis Holding Sa Ecublens | Verwendung von Oxazin-Farbstoffen als Markierungsgruppen für die Einzelmolekülanalyse |
| EP1658294B1 (en) * | 2003-08-18 | 2007-01-10 | Novartis AG | 3h-phenoxazine derivatives suitable as near-infrared imaging agents, preparation an use thereof |
| BRPI0503921A (pt) * | 2004-06-18 | 2006-07-18 | Oreal | composição cosmética, processos para tintura das fibras queratìnicas, processo para clareamento das fibras queratìnicas, dispositivo com múltiplos compartimentos, uso de composto hidroxialquilado e uso de uma composição de tintura |
| US7326258B2 (en) | 2004-06-18 | 2008-02-05 | L'oreal S.A. | Compositions comprising hydroxyalkyl direct dyes, implementation processes and uses thereof |
| WO2009107448A1 (ja) * | 2008-02-29 | 2009-09-03 | 独立行政法人理化学研究所 | チオールの検出方法 |
| US20120010404A1 (en) * | 2008-06-10 | 2012-01-12 | Sigma-Aldrich Co. | Oxazine dyes with improved aqueous solubility |
| GB0903348D0 (en) * | 2009-02-27 | 2009-04-08 | Pharmalucia Ltd | Compounds and methods relating thereto |
| CN103044947B (zh) * | 2013-01-09 | 2014-05-21 | 大连理工大学 | 一类尼罗蓝荧光染料，其制备方法及应用 |
| WO2015066296A1 (en) | 2013-10-31 | 2015-05-07 | Beth Israel Deaconess Medical Center | Near-infrared fluorescent nerve contrast agents and methods of use thereof |
| EP4147724A1 (en) * | 2013-10-31 | 2023-03-15 | Beth Israel Deaconess Medical Center | Near-infrared fluorescent contrast bioimaging agents and methods of use thereof |
| US12440585B2 (en) | 2023-09-12 | 2025-10-14 | Curadel Surgical Innovations, Inc. | Zwitterionic metal chelators |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1488609A (en) * | 1924-04-01 | murphy | ||
| DE287040C (Direct) | ||||
| JPS501576B2 (Direct) * | 1972-04-25 | 1975-01-20 | ||
| GB1410815A (en) * | 1972-12-20 | 1975-10-22 | Ici Ltd | Oxazine dyestuffs |
| DE2411761A1 (de) | 1974-03-12 | 1975-10-16 | Hoechst Ag | Basische oxazinfarbstoffe, verfahren zu ihrer herstellung und ihre verwendung |
| US4622395A (en) * | 1984-10-01 | 1986-11-11 | Minnesota Mining And Manufacturing Company | Phenoxazine and phenothiazine dyes and leuco forms thereof |
| US4714763A (en) * | 1985-07-11 | 1987-12-22 | Viomedics Inc. | Novel oxazine-ureas and thiazine urea chromophors as fluorescent labels |
| US4780535A (en) * | 1986-11-21 | 1988-10-25 | Spyros Theodoropulos | Maleic and phthalic diamides |
| US4965349A (en) * | 1987-12-24 | 1990-10-23 | Applied Biosystems, Inc. | Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports |
| US4962197A (en) * | 1988-02-12 | 1990-10-09 | Rowland Institute For Science | Photo-inactivation of cancer cells |
| IL91673A0 (en) * | 1988-09-20 | 1990-04-29 | Us Health | Method for tagging an oligodeoxynucleotide |
| DD287040A5 (de) * | 1989-07-28 | 1991-02-14 | Veb Forschungszentrum Biotechnologie Berlin,De | Neue fluophorderivate, verfahren zu ihrer herstellung und deren verwendung zur herstellung neuartiger fluoreszenzmarkierter nucleoside, nucleotide und oligonucleotide |
| GB9024775D0 (en) * | 1990-11-14 | 1991-01-02 | Axis Research | Chemical compounds |
| JPH05170752A (ja) * | 1991-04-26 | 1993-07-09 | Takeda Chem Ind Ltd | ３，７−ビス（ジ置換アミノ）フェノチアジン誘導体およびその製造法 |
| US5344928A (en) | 1991-04-26 | 1994-09-06 | Takeda Chemical Industries, Ltd. | Phenothiazine derivatives, their production and use |
| ES2137978T3 (es) | 1992-12-15 | 2000-01-01 | Ciba Sc Holding Ag | Colorantes de oxazina, procedimiento para su fabricacion y su utilizacion. |
| US5656759A (en) | 1993-07-22 | 1997-08-12 | Sony Corporation | Hydrophobic cationic dye compounds |
| US5792389A (en) | 1993-10-27 | 1998-08-11 | United States Of America | Water soluble laser dyes |
| US5620842A (en) * | 1995-03-29 | 1997-04-15 | Becton Dickinson And Company | Determination of the number of fluorescent molecules on calibration beads for flow cytometry |
| DE19521231A1 (de) * | 1995-06-10 | 1996-12-12 | Boehringer Mannheim Gmbh | Neue Oxazinfarbstoffe und ihre Verwendung als Fluoreszenzmarker |
| GB9602265D0 (en) * | 1996-02-05 | 1996-04-03 | Amersham Int Plc | Benzophenoxazine dyes |
| GB9716476D0 (en) | 1997-08-04 | 1997-10-08 | Amersham Int Plc | Dye intermediate and method |
| FR2780791B1 (fr) | 1998-07-03 | 2000-09-01 | Bio Merieux | Methode de depistage ou de diagnostic d'un adenocarcinome ou d'une pathologie benigne de la prostate et procede de mise en oeuvre |
| US6140500A (en) * | 1999-09-03 | 2000-10-31 | Pe Corporation | Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use |
| US6727356B1 (en) | 1999-12-08 | 2004-04-27 | Epoch Pharmaceuticals, Inc. | Fluorescent quenching detection reagents and methods |
| US6465644B1 (en) * | 2000-05-02 | 2002-10-15 | Applera Corporation | Sulfonated [8,9] benzophenoxazine dyes and the use of their labelled conjugates |
| US7101999B2 (en) | 2000-09-06 | 2006-09-05 | Evotec Ag | Oxazine derivatives |
| US6908769B2 (en) * | 2000-11-16 | 2005-06-21 | Roche Diagnostics Gmbh | Dye pair for fluorescence resonance energy transfer (FRET) measurements |
-
2001
- 2001-09-05 US US10/363,813 patent/US7101999B2/en not_active Expired - Fee Related
- 2001-09-05 WO PCT/EP2001/010236 patent/WO2002020670A1/de not_active Ceased
- 2001-09-05 EP EP01978341A patent/EP1317511B1/de not_active Expired - Lifetime
- 2001-09-05 EP EP05000174A patent/EP1535967B1/de not_active Expired - Lifetime
- 2001-09-05 JP JP2002525681A patent/JP2004508448A/ja active Pending
- 2001-09-05 DE DE50105139T patent/DE50105139D1/de not_active Expired - Lifetime
- 2001-09-05 AT AT05000174T patent/ATE518913T1/de active
- 2001-09-05 AT AT01978341T patent/ATE287430T1/de not_active IP Right Cessation
-
2006
- 2006-04-20 US US11/379,433 patent/US20060240455A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7101999B2 (en) | 2006-09-05 |
| US20040029837A1 (en) | 2004-02-12 |
| ATE287430T1 (de) | 2005-02-15 |
| EP1535967A1 (de) | 2005-06-01 |
| US20060240455A1 (en) | 2006-10-26 |
| WO2002020670A1 (de) | 2002-03-14 |
| EP1317511A1 (de) | 2003-06-11 |
| EP1317511B1 (de) | 2005-01-19 |
| EP1535967B1 (de) | 2011-08-03 |
| DE50105139D1 (en) | 2005-02-24 |
| JP2004508448A (ja) | 2004-03-18 |
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