ATE516504T1 - Um den einfluss von störfaktoren korrigierte messung des zeitlichen verlaufs einer enzymatischen aktivität bei der reaktion eines enzyms mit einem substrat - Google Patents

Um den einfluss von störfaktoren korrigierte messung des zeitlichen verlaufs einer enzymatischen aktivität bei der reaktion eines enzyms mit einem substrat

Info

Publication number
ATE516504T1
ATE516504T1 AT08151181T AT08151181T ATE516504T1 AT E516504 T1 ATE516504 T1 AT E516504T1 AT 08151181 T AT08151181 T AT 08151181T AT 08151181 T AT08151181 T AT 08151181T AT E516504 T1 ATE516504 T1 AT E516504T1
Authority
AT
Austria
Prior art keywords
enzyme
substrate
signal
activity
measurement
Prior art date
Application number
AT08151181T
Other languages
English (en)
Inventor
Hendrik Coenraad Hemker
Pieter Wilhelm Hemker
Original Assignee
Synapse Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synapse Bv filed Critical Synapse Bv
Application granted granted Critical
Publication of ATE516504T1 publication Critical patent/ATE516504T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT08151181T 2008-02-07 2008-02-07 Um den einfluss von störfaktoren korrigierte messung des zeitlichen verlaufs einer enzymatischen aktivität bei der reaktion eines enzyms mit einem substrat ATE516504T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08151181A EP2088435B1 (de) 2008-02-07 2008-02-07 Um den Einfluss von Störfaktoren korrigierte Messung des zeitlichen Verlaufs einer enzymatischen Aktivität bei der Reaktion eines Enzyms mit einem Substrat

Publications (1)

Publication Number Publication Date
ATE516504T1 true ATE516504T1 (de) 2011-07-15

Family

ID=39203204

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08151181T ATE516504T1 (de) 2008-02-07 2008-02-07 Um den einfluss von störfaktoren korrigierte messung des zeitlichen verlaufs einer enzymatischen aktivität bei der reaktion eines enzyms mit einem substrat

Country Status (4)

Country Link
US (1) US8551722B2 (de)
EP (1) EP2088435B1 (de)
AT (1) ATE516504T1 (de)
WO (1) WO2009098313A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8293493B2 (en) * 2010-01-27 2012-10-23 Adventist Health System/Sunbelt, Inc. Thrombin generation determination method
RU2518247C2 (ru) * 2011-07-26 2014-06-10 Общество с ограниченной ответственностью "ГемаКор Лабс" (ООО "ГемаКор Лабс") Способ определения пространственно-временного распределения активности протеолитического фермента в гетерогенной системе, устройство для реализации указанного способа и способ диагностики нарушений системы гемостаза по изменению пространственно-временного распределения активности протеолитического фермента в гетерогенной системе
EP2677037B1 (de) 2012-06-21 2016-04-13 Synapse B.V. Gleichzeitige Messung der Thrombinerzeugung und Gerinnselfestigkeit in Plasma und im gesamten Blut
US10794896B2 (en) 2016-01-29 2020-10-06 Sony Corporation Blood coagulation system examination module, blood coagulation system examination system, blood coagulation system examination method, and determination method of parameter for blood coagulation system examination module
EP3363912B1 (de) 2017-02-17 2020-10-28 Synapse B.V. Selbstkalibrierter assay zur bestimmung der erzeugung von proteolytischem enzym, dedizierte mittel und verwendungen davon
CN116793976B (zh) * 2023-06-29 2024-05-10 徐詹程 一种酶促反应分析底物浓度拟合标准曲线的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287180A (en) * 1980-01-28 1981-09-01 Baxter Travenol Laboratories, Inc. Method for treating blood clotting factor inhibitors
EP0711992B1 (de) 1994-11-08 2003-03-26 Tosoh Corporation Verfahren zur Bestimmung einer fluoreszierenden Substanz, sowie Verfahren zur Enzym-Aktivität-Bestimmung
JP4718833B2 (ja) 2002-05-01 2011-07-06 シナプス ベスローテン フェンノートシャップ 複合生物媒体における、一時的なタンパク質分解活性の濃度を決定するための診断試験
EP1717588A1 (de) 2005-04-29 2006-11-02 Synapse B.V. Bestimmung der Thrombinaktivität in Vollblut
KR20090034860A (ko) 2006-06-06 2009-04-08 드롬비노스코프 비.브이. 생물학적 매질에서 효소 활성을 측정하는 방법
CA2668356A1 (en) * 2006-11-02 2008-05-08 Thrombinoscope B.V. Method for measuring the concentration of transient proteolytic activity in composite biological media containing cells

Also Published As

Publication number Publication date
WO2009098313A1 (en) 2009-08-13
EP2088435A1 (de) 2009-08-12
EP2088435B1 (de) 2011-07-13
US20110045512A1 (en) 2011-02-24
US8551722B2 (en) 2013-10-08

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