ATE515566T1 - Skalierbares fermentationsverfahren - Google Patents

Skalierbares fermentationsverfahren

Info

Publication number
ATE515566T1
ATE515566T1 AT06777243T AT06777243T ATE515566T1 AT E515566 T1 ATE515566 T1 AT E515566T1 AT 06777243 T AT06777243 T AT 06777243T AT 06777243 T AT06777243 T AT 06777243T AT E515566 T1 ATE515566 T1 AT E515566T1
Authority
AT
Austria
Prior art keywords
capsid protein
fermentation process
expression
scalable
vlp
Prior art date
Application number
AT06777243T
Other languages
English (en)
Inventor
Marcel Emmerling
Frank Hennecke
Holger Pfruender
Martin Rhiel
Philipp Steiner
Original Assignee
Cytos Biotechnology Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05011416A external-priority patent/EP1726642A1/de
Priority claimed from EP05106729A external-priority patent/EP1746165A1/de
Application filed by Cytos Biotechnology Ag filed Critical Cytos Biotechnology Ag
Application granted granted Critical
Publication of ATE515566T1 publication Critical patent/ATE515566T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10061—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18051—Methods of production or purification of viral material
    • C12N2795/18052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT06777243T 2005-05-26 2006-05-24 Skalierbares fermentationsverfahren ATE515566T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05011416A EP1726642A1 (de) 2005-05-26 2005-05-26 Grossschaliger Fermentationsverfahren für Bakteriophagen
EP05106729A EP1746165A1 (de) 2005-07-21 2005-07-21 Skalierbares Fermentations-Verfahren
PCT/EP2006/062628 WO2006125821A2 (en) 2005-05-26 2006-05-24 Scalable fermentation process

Publications (1)

Publication Number Publication Date
ATE515566T1 true ATE515566T1 (de) 2011-07-15

Family

ID=37434299

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06777243T ATE515566T1 (de) 2005-05-26 2006-05-24 Skalierbares fermentationsverfahren

Country Status (10)

Country Link
US (6) US20110008831A1 (de)
EP (1) EP1885847B1 (de)
JP (1) JP5442251B2 (de)
CN (1) CN101213294B (de)
AT (1) ATE515566T1 (de)
AU (1) AU2006251098B2 (de)
CA (1) CA2608579C (de)
IL (1) IL187341A (de)
NZ (1) NZ563708A (de)
WO (1) WO2006125821A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2427994T3 (es) 2006-06-12 2013-11-05 Cytos Biotechnology Ag Procesos para empaquetar oligonucleótidos en partículas de tipo viral de bacteriófagos de ARN
US11889986B2 (en) 2010-12-09 2024-02-06 Endochoice, Inc. Flexible electronic circuit board for a multi-camera endoscope
BR112017020916B1 (pt) * 2015-04-02 2022-01-25 Scarab Genomics, Llc Processo de fermentação contínua para a produção de produto biológico
US20190161543A1 (en) 2016-01-06 2019-05-30 Outlook Therapeutics, Inc. Modulation of afucosylated species in a monoclonal antibody composition
CN109563161A (zh) 2016-02-03 2019-04-02 安口生物公司 用于提高抗体稳定性的缓冲制剂
CN115927299A (zh) * 2016-03-15 2023-04-07 核糖核酸复兴股份有限责任公司 增加双链rna产生的方法和组合物
JP7511478B2 (ja) 2018-04-09 2024-07-05 チェックメイト ファーマシューティカルズ ウイルス様粒子中へのオリゴヌクレオチドのパッケージ化
WO2020203885A1 (ja) * 2019-03-29 2020-10-08 味の素株式会社 アロラクトースの製造法
CA3155202A1 (en) 2019-10-23 2021-04-29 Arthur M. Krieg Synthetic rig-i-like receptor agonists
US20220241400A1 (en) * 2021-02-02 2022-08-04 Provaxus, Inc. Immunomodulation platform and methods of use

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8924883D0 (en) * 1989-11-03 1989-12-20 Shell Int Research Expression vector and polypeptide synthesis
DE4017595A1 (de) * 1990-05-31 1991-12-05 Consortium Elektrochem Ind Maltopentaose produzierende amylasen
GB9022190D0 (en) * 1990-10-12 1990-11-28 Perham Richard N Immunogenic material
GB9101550D0 (en) * 1991-01-24 1991-03-06 Mastico Robert A Antigen-presenting chimaeric protein
US5356792A (en) * 1991-11-22 1994-10-18 Nakano Vinegar Co., Ltd. Biochemical oxygen demand analyzer and methods of analysis using Klebsiella microorganisms
GB9213601D0 (en) * 1992-06-26 1992-08-12 Mastico Robert A Protein based delivery system
BR9907691B1 (pt) * 1998-02-05 2011-05-31 derivado de antìgeno e antìgeno da famìlia mage associado a tumor, seqüência de ácido nucléico, codificando os mesmos, seus usos na preparação de vacina, processo para produção de vacina e vacina.
US6291245B1 (en) * 1998-07-15 2001-09-18 Roche Diagnostics Gmbh Host-vector system
DE19943919B4 (de) * 1999-09-14 2004-05-27 Pharmacia Ab Verfahren zur Steigerung der Ausbeute von rekombinanten Proteinen in mikrobiellen Fermentationsprozessen
US6833260B1 (en) * 1999-10-08 2004-12-21 Protein Scientific, Inc. Lactose hydrolysis
IL138529A0 (en) * 2000-09-18 2003-09-17 Yeda Res & Dev High level expression of heterologous proteins
US20060280724A1 (en) * 2000-11-04 2006-12-14 Ferguson Ian A Identification of ligands that enable endocytosis, using in vivo manipulation of neuronal fibers
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
EP1381672A4 (de) * 2001-02-28 2006-01-25 Trustees Of Board Of Biosynthese von polyketidsynthasesubstraten
US20040214314A1 (en) * 2001-11-02 2004-10-28 Friedrich Srienc High throughput bioreactor
GB0129105D0 (en) * 2001-12-05 2002-01-23 Celltech R&D Ltd Expression control using variable intergenic sequences
US7332304B2 (en) * 2002-07-01 2008-02-19 Arkion Life Sciences Llc Process and materials for production of glucosamine and N-acetylglucosamine
MXPA05000277A (es) * 2002-07-17 2005-03-31 Cytos Biotechnology Ag Configuraciones de antigenos moleculares de usan una particula tipo virus derivada de la proteina de recurimiento ap205.
WO2004016282A1 (en) * 2002-07-19 2004-02-26 Cytos Biotechnology Ag Vaccine compositions containing amyloid beta1-6 antigen arrays
DE60307294D1 (de) * 2002-09-27 2006-09-14 Dsm Ip Assets Bv Transkriptionsaktivator-gen für gene, die beteiligt sind an der biosynthese von cobalamin
US7250274B2 (en) * 2002-12-13 2007-07-31 Zymogenetics, Inc. IL-21 production in prokaryotic hosts
EP1605972A2 (de) * 2003-03-26 2005-12-21 Cytos Biotechnology AG Hiv-peptid-träger-konjugate
GB0321100D0 (en) * 2003-09-09 2003-10-08 Celltech R&D Ltd Biological products
ATE498691T1 (de) * 2003-10-21 2011-03-15 Cargill Inc Herstellung von monatin und monatinvorstufen
US7572451B2 (en) * 2004-10-25 2009-08-11 Cytos Biotechnology Ag Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof
BRPI0419235A (pt) * 2004-12-21 2007-12-18 Usv Ltd processo de fermentação de densidade de célula baixa para a produção de proteìnas recombinantes heterólogas em microorganismos
CA2636139A1 (en) * 2005-12-14 2007-06-21 Cytos Biotechnology Ag Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity

Also Published As

Publication number Publication date
US20220089648A1 (en) 2022-03-24
AU2006251098B2 (en) 2011-09-15
US20170305972A1 (en) 2017-10-26
CN101213294A (zh) 2008-07-02
NZ563708A (en) 2010-08-27
IL187341A0 (en) 2008-04-13
WO2006125821A3 (en) 2007-03-22
US20200223891A1 (en) 2020-07-16
EP1885847B1 (de) 2011-07-06
JP5442251B2 (ja) 2014-03-12
US9518095B2 (en) 2016-12-13
CN101213294B (zh) 2013-03-27
EP1885847A2 (de) 2008-02-13
IL187341A (en) 2012-08-30
WO2006125821A2 (en) 2006-11-30
CA2608579C (en) 2019-09-10
AU2006251098A1 (en) 2006-11-30
CA2608579A1 (en) 2006-11-30
JP2008545401A (ja) 2008-12-18
US20110008831A1 (en) 2011-01-13
US20120322103A1 (en) 2012-12-20
US20150104827A1 (en) 2015-04-16

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