ATE513191T1 - System und verfahren für hochsensitive vibrationsbildgebung mit frequenzmodulierter kohärenter anti-stokes-ramanstreuungsanalyse - Google Patents

System und verfahren für hochsensitive vibrationsbildgebung mit frequenzmodulierter kohärenter anti-stokes-ramanstreuungsanalyse

Info

Publication number
ATE513191T1
ATE513191T1 AT06817339T AT06817339T ATE513191T1 AT E513191 T1 ATE513191 T1 AT E513191T1 AT 06817339 T AT06817339 T AT 06817339T AT 06817339 T AT06817339 T AT 06817339T AT E513191 T1 ATE513191 T1 AT E513191T1
Authority
AT
Austria
Prior art keywords
sub
omega
frequency
stokes
ram
Prior art date
Application number
AT06817339T
Other languages
English (en)
Inventor
Xiaoliang Xie
Feruz Ganikhanov
Connor Evans
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of ATE513191T1 publication Critical patent/ATE513191T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/42—Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
    • G01J3/433—Modulation spectrometry; Derivative spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/1757—Time modulation of light being essential to the method of light modification, e.g. using single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/636—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited using an arrangement of pump beam and probe beam; using the measurement of optical non-linear properties

Landscapes

  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AT06817339T 2005-10-26 2006-10-24 System und verfahren für hochsensitive vibrationsbildgebung mit frequenzmodulierter kohärenter anti-stokes-ramanstreuungsanalyse ATE513191T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73055805P 2005-10-26 2005-10-26
US76018906P 2006-01-19 2006-01-19
US11/376,396 US7352458B2 (en) 2005-10-26 2006-03-15 System and method for high sensitivity vibrational imaging with frequency modulation coherent anti-stokes Raman scattering analyses
PCT/US2006/041459 WO2007050596A1 (en) 2005-10-26 2006-10-24 System and method for high sensitivity vibrational imaging with frequency modulation coherent anti-stokes raman scattering analyses

Publications (1)

Publication Number Publication Date
ATE513191T1 true ATE513191T1 (de) 2011-07-15

Family

ID=37680708

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06817339T ATE513191T1 (de) 2005-10-26 2006-10-24 System und verfahren für hochsensitive vibrationsbildgebung mit frequenzmodulierter kohärenter anti-stokes-ramanstreuungsanalyse

Country Status (5)

Country Link
US (1) US7352458B2 (de)
EP (1) EP1941251B1 (de)
JP (1) JP4860705B2 (de)
AT (1) ATE513191T1 (de)
WO (1) WO2007050596A1 (de)

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US7586602B2 (en) * 2006-07-24 2009-09-08 General Electric Company Method and apparatus for improved signal to noise ratio in Raman signal detection for MEMS based spectrometers
DE102006034909A1 (de) * 2006-07-28 2008-01-31 Carl Zeiss Microimaging Gmbh Verfahren zur Laser-Scanning-Mikroskopie und Strahlvereiniger
US20080117416A1 (en) * 2006-10-27 2008-05-22 Hunter Ian W Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same
US7570349B2 (en) * 2007-05-15 2009-08-04 The Boeing Company Cars/absorption dual mode electro-optic sensor
US20100027000A1 (en) * 2007-10-29 2010-02-04 Dimitry Pestov Hybrid Technique for Coherent Anti-Stokes/Stokes Raman Spectroscopy
US7760352B2 (en) * 2008-03-18 2010-07-20 Itt Manufacturing Enterprises, Inc. Dual pulse single event Raman spectroscopy
US8027032B2 (en) * 2008-08-22 2011-09-27 President & Fellows Of Harvard College Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism
US8120772B2 (en) * 2008-11-03 2012-02-21 The United States of America as represented by the Secretary of Commerce, the National Institute of Standards and Technology Method for NRB-free nonlinear vibrational spectroscopy and miscroscopy
US9285575B2 (en) * 2009-01-26 2016-03-15 President And Fellows Of Harvard College Systems and methods for selective detection and imaging in coherent Raman microscopy by spectral excitation shaping
FR2955663B1 (fr) 2010-01-22 2014-09-12 Ct Nat De La Rech C N R S Methode pour la detection d'un signal optique non lineaire resonant et dispositif pour la mise en oeuvre de ladite methode
WO2011162787A1 (en) 2010-06-22 2011-12-29 President And Fellows Of Harvard College Systems and methods providing efficient detection of back-scattered illumination in modulation transfer microscopy or micro-spectroscopy
JP2012237714A (ja) * 2011-05-13 2012-12-06 Sony Corp 非線形ラマン分光装置、顕微分光装置及び顕微分光イメージング装置
CN103134756B (zh) * 2013-02-28 2016-04-20 华南师范大学 偏振态层析显微成像装置及方法
FR3003949B1 (fr) * 2013-03-26 2015-05-01 Univ Aix Marseille Dispositif et methode de detection raman stimulee.
US10267739B2 (en) 2013-08-02 2019-04-23 Board Of Trustees Of Michigan State University Laser system for standoff detection
DE102013224412A1 (de) * 2013-11-28 2015-05-28 Leica Microsystems Cms Gmbh Verfahren zur Untersuchung einer Probe durch CARS-Mikroskopie
EP3096131A1 (de) * 2015-05-18 2016-11-23 International Iberian Nanotechnology Laboratory Optische faser zur verwendung in einem system zur detektion einer oder mehrerer verbindungen in einer flüssigkeit
DE102015225871B4 (de) 2015-12-18 2017-07-27 Carl Zeiss Microscopy Gmbh Verfahren der Stimulierten Raman-Mikroskopie und Mikroskop
EP3415898A4 (de) * 2016-02-09 2019-09-11 The University Of Tokyo Stimuliertes raman-streuungsmikroskop und stimuliertes raman-streuungsmessverfahren
CN109030451B (zh) * 2018-06-08 2021-01-05 天津大学 Cars显微成像系统中超短脉冲时间重叠度测量装置和方法
CN109557070B (zh) * 2018-10-27 2021-03-26 西安电子科技大学 一种基于空间编码光的拉曼成像系统
CN112462507B (zh) * 2020-10-22 2022-05-10 北京航空航天大学 抑制相干反斯托克斯拉曼散射显微镜非共振背景信号的方法、成像方法及系统

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US4405237A (en) * 1981-02-04 1983-09-20 The United States Of America As Represented By The Secretary Of The Navy Coherent anti-Stokes Raman device
JPH10160595A (ja) * 1996-11-29 1998-06-19 Osaka Gas Co Ltd コヒーレント反ストークスラマン分光法を用いたレーザー温度計測方法と装置
US6356381B1 (en) * 1997-12-19 2002-03-12 The United States Of America As Represented By The Secretary Of Commerce Multi-wavelength cross-correlator for ultrashort radiation pulses
US6108081A (en) * 1998-07-20 2000-08-22 Battelle Memorial Institute Nonlinear vibrational microscopy
US6608716B1 (en) * 1999-05-17 2003-08-19 New Mexico State University Technology Transfer Corporation Optical enhancement with nanoparticles and microcavities
ATE543080T1 (de) * 2000-07-13 2012-02-15 Harvard College System und verfahren für die epidetektions- kohärenz-anti-stokes-raman-streumikroskopie
JP4212471B2 (ja) * 2001-07-03 2009-01-21 プレジデント アンド フェローズ オブ ハーバード カレッジ 偏光コヒーレントアンチストークスラマン散乱顕微鏡使用のシステム及び方法
JP4854878B2 (ja) * 2001-07-03 2012-01-18 オリンパス株式会社 レーザー顕微鏡
GB0327755D0 (en) 2003-12-01 2003-12-31 Elliott Stephen R Optical-sensor chip
US7388668B2 (en) * 2004-06-09 2008-06-17 President & Fellows Of Harvard College Phase sensitive heterodyne coherent anti-Stokes Raman scattering micro-spectroscopy and microscopy
JP2009150649A (ja) * 2005-03-29 2009-07-09 Osaka Univ 空間情報検出装置

Also Published As

Publication number Publication date
JP2009513981A (ja) 2009-04-02
WO2007050596A1 (en) 2007-05-03
US7352458B2 (en) 2008-04-01
EP1941251A1 (de) 2008-07-09
JP4860705B2 (ja) 2012-01-25
US20070091305A1 (en) 2007-04-26
EP1941251B1 (de) 2011-06-15

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