ATE505533T1 - Antigenpräsentierende zellen, verfahren zu ihrer herstellung sowie ihre verwendung für krebsimpfstoffe - Google Patents
Antigenpräsentierende zellen, verfahren zu ihrer herstellung sowie ihre verwendung für krebsimpfstoffeInfo
- Publication number
- ATE505533T1 ATE505533T1 AT02791520T AT02791520T ATE505533T1 AT E505533 T1 ATE505533 T1 AT E505533T1 AT 02791520 T AT02791520 T AT 02791520T AT 02791520 T AT02791520 T AT 02791520T AT E505533 T1 ATE505533 T1 AT E505533T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- associated antigens
- tumor associated
- antigen
- presenting cells
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 210000000612 antigen-presenting cell Anatomy 0.000 title abstract 2
- 229940022399 cancer vaccine Drugs 0.000 title 1
- 238000009566 cancer vaccine Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 9
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 230000001413 cellular effect Effects 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 229940075628 hypomethylating agent Drugs 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0694—Cells of blood, e.g. leukemia cells, myeloma cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/13—B-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/06—Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/52—CD40, CD40-ligand (CD154)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/59—Lectins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IT2001/000419 WO2003012085A1 (en) | 2001-07-30 | 2001-07-30 | Antigen presenting cells, method for their preparation and their use for cancer vaccines |
| PCT/IT2002/000488 WO2003012086A1 (en) | 2001-07-30 | 2002-07-25 | Antigen presenting cells, method for their preparation and their use for cancer vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE505533T1 true ATE505533T1 (de) | 2011-04-15 |
Family
ID=11133712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02791520T ATE505533T1 (de) | 2001-07-30 | 2002-07-25 | Antigenpräsentierende zellen, verfahren zu ihrer herstellung sowie ihre verwendung für krebsimpfstoffe |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20030119187A1 (enExample) |
| EP (1) | EP1412485B1 (enExample) |
| JP (1) | JP2004536615A (enExample) |
| KR (1) | KR100916670B1 (enExample) |
| CN (1) | CN100591762C (enExample) |
| AT (1) | ATE505533T1 (enExample) |
| AU (1) | AU2002334387B2 (enExample) |
| BR (1) | BR0211520A (enExample) |
| CA (1) | CA2453522C (enExample) |
| DE (1) | DE60239741D1 (enExample) |
| DK (1) | DK1412485T3 (enExample) |
| ES (1) | ES2367256T3 (enExample) |
| HU (1) | HUP0401753A3 (enExample) |
| MX (1) | MXPA04000885A (enExample) |
| PL (1) | PL211907B1 (enExample) |
| WO (2) | WO2003012085A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003012085A1 (en) | 2001-07-30 | 2003-02-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Antigen presenting cells, method for their preparation and their use for cancer vaccines |
| US6982253B2 (en) | 2002-06-05 | 2006-01-03 | Supergen, Inc. | Liquid formulation of decitabine and use of the same |
| US7695725B2 (en) * | 2003-02-06 | 2010-04-13 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
| PT1592441E (pt) * | 2003-02-06 | 2012-05-21 | Aduro Biotech | Listeria atenuada relativamente à entrada em células não patogénicas, vacinas compreendendo a listeria e métodos para sua utilização |
| WO2004084936A2 (en) * | 2003-02-06 | 2004-10-07 | Cerus Corporation | Modified free-living microbes, vaccine compositions and methods of use thereof |
| DE10329240A1 (de) * | 2003-06-24 | 2005-01-20 | Epigenomics Ag | Verfahren zur Analyse des Cytosin-Methylierungsstatus von Cancer-Testis-Antigenen für eine individualisierte Immuntherapie |
| US7842289B2 (en) * | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| ES2390967T3 (es) * | 2004-01-20 | 2012-11-20 | Aichi Prefecture | Epítopo/péptido reconocido por LTC específico para Ep-CAM con restricción por ALH-A2402 y su utilización |
| WO2005075646A1 (ja) * | 2004-02-03 | 2005-08-18 | Kurume University | ストレス誘導抗アポトーシス分子（ｉｅｘ−１）由来ペプチド |
| US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
| WO2007011693A2 (en) | 2005-07-14 | 2007-01-25 | Medistem Laboratories, Inc. | Compositions of placentally-derived stem cells for the treatment of cancer |
| US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| GB0700058D0 (en) * | 2007-01-03 | 2007-02-07 | Scancell Aps | Anti-tumor vaccine based on normal cells |
| JP2013512694A (ja) * | 2009-12-08 | 2013-04-18 | ウィルソン ウォルフ マニュファクチャリング コーポレイション | 養子細胞療法のための細胞を培養する方法 |
| PL2729008T3 (pl) * | 2011-07-07 | 2017-10-31 | Res Cancer Institute Of America | Systemy, sposoby i formulacje do leczenia raka |
| US8933078B2 (en) | 2011-07-14 | 2015-01-13 | Research Cancer Institute Of America | Method of treating cancer with combinations of histone deacetylase inhibitors (HDAC1) substances |
| BR112014004779B1 (pt) | 2011-08-30 | 2022-01-18 | Astex Pharmaceuticals, Inc | Formulações de derivados de decitabina, kit e processos relacionados |
| EP3662911A1 (en) * | 2012-10-30 | 2020-06-10 | MEI Pharma, Inc. | Combination of azacitidine and pracinostat to treat myelodysplastic syndrome (mds) |
| US9562219B2 (en) * | 2013-12-27 | 2017-02-07 | SOTIO a.s. | Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer |
| CA2986687A1 (en) * | 2015-05-22 | 2016-12-01 | Brian J. Czerniecki | Manufacturing multi-dose injection ready dendritic cell vaccines |
| MX2018000016A (es) | 2015-07-02 | 2019-01-31 | Otsuka Pharma Co Ltd | Composiciones farmaceuticas liofilizadas. |
| CN105132371B (zh) * | 2015-07-24 | 2016-05-25 | 北京鼎成肽源生物技术有限公司 | 体外提呈、激活dc细胞的方法及其应用 |
| US10052372B2 (en) * | 2016-05-24 | 2018-08-21 | Tessa Therapeutics Pte Ltd | T cell expansion |
| US11890292B2 (en) | 2017-02-27 | 2024-02-06 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| US11369585B2 (en) | 2017-03-17 | 2022-06-28 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| MX2020001233A (es) | 2017-08-03 | 2020-07-20 | Otsuka Pharma Co Ltd | Compuesto farmaceutico y metodos de purificacion del mismo. |
| CN107557333B (zh) * | 2017-10-16 | 2018-07-31 | 北京鼎成肽源生物技术有限公司 | 一种用于细胞治疗的新抗原呈递细胞的制备方法 |
| EP3710434A4 (en) | 2017-11-17 | 2021-07-28 | Research Cancer Institute of America | COMPOSITIONS, METHODS, SYSTEMS AND / OR KITS FOR THE PREVENTION AND / OR TREATMENT OF NEOPLASMS |
| KR102319259B1 (ko) | 2019-07-26 | 2021-10-28 | 정재웅 | 지반천공기용 확장리더 안전제어장치 |
| WO2021027057A1 (zh) * | 2019-08-15 | 2021-02-18 | 成都冕康生物科技有限公司 | 一种针对ebv病毒抗原的b细胞疫苗及其制备方法 |
| CN114099655A (zh) * | 2021-11-16 | 2022-03-01 | 苏州大学 | 一种预防或治疗癌症的疫苗系统及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0817854A2 (en) * | 1995-03-31 | 1998-01-14 | Wolf, Hans, Prof. Dr. | Antigen presentation system based on retrovirus-like particles |
| ES2279580T3 (es) * | 1997-09-15 | 2007-08-16 | Genetic Immunity, Llc | Composiciones para administrar genes a celulas de la piel que presentan antigenos. |
| US6613753B2 (en) | 2001-02-21 | 2003-09-02 | Supergen, Inc. | Restore cancer-suppressing functions to neoplastic cells through DNA hypomethylation |
| WO2003012085A1 (en) * | 2001-07-30 | 2003-02-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Antigen presenting cells, method for their preparation and their use for cancer vaccines |
-
2001
- 2001-07-30 WO PCT/IT2001/000419 patent/WO2003012085A1/en not_active Ceased
- 2001-10-18 US US09/981,239 patent/US20030119187A1/en not_active Abandoned
-
2002
- 2002-07-25 CA CA2453522A patent/CA2453522C/en not_active Expired - Lifetime
- 2002-07-25 DE DE60239741T patent/DE60239741D1/de not_active Expired - Lifetime
- 2002-07-25 HU HU0401753A patent/HUP0401753A3/hu unknown
- 2002-07-25 PL PL367617A patent/PL211907B1/pl unknown
- 2002-07-25 CN CN02815007A patent/CN100591762C/zh not_active Expired - Lifetime
- 2002-07-25 EP EP02791520A patent/EP1412485B1/en not_active Expired - Lifetime
- 2002-07-25 KR KR1020047001217A patent/KR100916670B1/ko not_active Expired - Fee Related
- 2002-07-25 US US10/485,351 patent/US7883889B2/en not_active Expired - Lifetime
- 2002-07-25 BR BR0211520-4A patent/BR0211520A/pt not_active Application Discontinuation
- 2002-07-25 MX MXPA04000885A patent/MXPA04000885A/es active IP Right Grant
- 2002-07-25 DK DK02791520.6T patent/DK1412485T3/da active
- 2002-07-25 AT AT02791520T patent/ATE505533T1/de not_active IP Right Cessation
- 2002-07-25 ES ES02791520T patent/ES2367256T3/es not_active Expired - Lifetime
- 2002-07-25 WO PCT/IT2002/000488 patent/WO2003012086A1/en not_active Ceased
- 2002-07-25 AU AU2002334387A patent/AU2002334387B2/en not_active Expired
- 2002-07-25 JP JP2003517263A patent/JP2004536615A/ja active Pending
-
2004
- 2004-07-26 US US10/898,187 patent/US20050002920A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1537161A (zh) | 2004-10-13 |
| WO2003012085A1 (en) | 2003-02-13 |
| JP2004536615A (ja) | 2004-12-09 |
| HUP0401753A3 (en) | 2011-04-28 |
| MXPA04000885A (es) | 2004-06-03 |
| PL367617A1 (en) | 2005-03-07 |
| BR0211520A (pt) | 2004-09-14 |
| EP1412485B1 (en) | 2011-04-13 |
| DE60239741D1 (de) | 2011-05-26 |
| KR100916670B1 (ko) | 2009-09-08 |
| EP1412485A1 (en) | 2004-04-28 |
| AU2002334387B2 (en) | 2007-10-04 |
| CN100591762C (zh) | 2010-02-24 |
| PL211907B1 (pl) | 2012-07-31 |
| US20040185563A1 (en) | 2004-09-23 |
| CA2453522C (en) | 2013-04-30 |
| DK1412485T3 (da) | 2011-08-01 |
| US20030119187A1 (en) | 2003-06-26 |
| WO2003012086A1 (en) | 2003-02-13 |
| KR20040021662A (ko) | 2004-03-10 |
| US20050002920A1 (en) | 2005-01-06 |
| US7883889B2 (en) | 2011-02-08 |
| CA2453522A1 (en) | 2003-02-13 |
| HK1068913A1 (zh) | 2005-05-06 |
| HUP0401753A2 (hu) | 2004-11-29 |
| ES2367256T3 (es) | 2011-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |