ATE505454T1 - 1-(4-(4-benzylbenzamid)-benzyl)-azetidin-3- carboxylsäurederivate und entsprechende verbindungen als s1p-rezeptor-modulatoren zur behandlung von immunerkrankungen - Google Patents
1-(4-(4-benzylbenzamid)-benzyl)-azetidin-3- carboxylsäurederivate und entsprechende verbindungen als s1p-rezeptor-modulatoren zur behandlung von immunerkrankungenInfo
- Publication number
- ATE505454T1 ATE505454T1 AT08831946T AT08831946T ATE505454T1 AT E505454 T1 ATE505454 T1 AT E505454T1 AT 08831946 T AT08831946 T AT 08831946T AT 08831946 T AT08831946 T AT 08831946T AT E505454 T1 ATE505454 T1 AT E505454T1
- Authority
- AT
- Austria
- Prior art keywords
- benzylbenzamide
- azetidine
- benzyl
- treatment
- carboxylic acid
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 208000026278 immune system disease Diseases 0.000 title abstract 2
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 abstract 2
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 208000006454 hepatitis Diseases 0.000 abstract 2
- 231100000283 hepatitis Toxicity 0.000 abstract 2
- 208000027496 Behcet disease Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010018364 Glomerulonephritis Diseases 0.000 abstract 1
- 206010018691 Granuloma Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 206010029164 Nephrotic syndrome Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010043561 Thrombocytopenic purpura Diseases 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 206010046851 Uveitis Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000001434 glomerular Effects 0.000 abstract 1
- 208000007475 hemolytic anemia Diseases 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 206010028417 myasthenia gravis Diseases 0.000 abstract 1
- 208000009928 nephrosis Diseases 0.000 abstract 1
- 231100001027 nephrosis Toxicity 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
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- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
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- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Obesity (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99481207P | 2007-09-20 | 2007-09-20 | |
| PCT/US2008/010887 WO2009038759A2 (en) | 2007-09-20 | 2008-09-19 | 1-(4-(benzylbenzamid0) -benzyl) azetidine-3-carboxylic acid derivatives and related compounds as slp receptor modulators for the treatment of immune disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE505454T1 true ATE505454T1 (de) | 2011-04-15 |
Family
ID=40468694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08831946T ATE505454T1 (de) | 2007-09-20 | 2008-09-19 | 1-(4-(4-benzylbenzamid)-benzyl)-azetidin-3- carboxylsäurederivate und entsprechende verbindungen als s1p-rezeptor-modulatoren zur behandlung von immunerkrankungen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8080542B2 (enExample) |
| EP (1) | EP2188252B1 (enExample) |
| JP (1) | JP2010540438A (enExample) |
| AT (1) | ATE505454T1 (enExample) |
| AU (1) | AU2008302746B2 (enExample) |
| CA (1) | CA2699417A1 (enExample) |
| DE (1) | DE602008006209D1 (enExample) |
| ES (1) | ES2360929T3 (enExample) |
| MX (1) | MX2010002885A (enExample) |
| WO (1) | WO2009038759A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7919519B2 (en) | 2005-11-23 | 2011-04-05 | Epix Pharmaceuticals Inc. | S1P receptor modulating compounds and use thereof |
| CA2630714C (en) | 2005-11-23 | 2014-01-14 | Epix Delaware, Inc. | S1p receptor modulating compounds and use thereof |
| US7790707B2 (en) | 2006-03-21 | 2010-09-07 | Epix Pharmaceuticals Inc. | S1P receptor modulating compounds and use thereof |
| US20090069288A1 (en) * | 2007-07-16 | 2009-03-12 | Breinlinger Eric C | Novel therapeutic compounds |
| US8080542B2 (en) | 2007-09-20 | 2011-12-20 | Amgen, Inc. | S1P receptor modulating compounds and use thereof |
| TW201000099A (en) * | 2008-06-20 | 2010-01-01 | Amgen Inc | S1P1 receptor agonists and use thereof |
| US8791100B2 (en) * | 2010-02-02 | 2014-07-29 | Novartis Ag | Aryl benzylamine compounds |
| EP2643303A1 (en) | 2010-11-24 | 2013-10-02 | Allergan, Inc. | Modulators of s1p receptors |
| FR3017867A1 (fr) * | 2014-02-21 | 2015-08-28 | Inventiva | Nouveaux composes de type phenylazetidine carboxylate ou carboxamide |
| US9718771B2 (en) | 2014-02-28 | 2017-08-01 | Kissei Pharmaceutical Co., Ltd. | Aniline derivative, pharmaceutical composition containing same, and use thereof |
| US9895324B2 (en) | 2014-03-26 | 2018-02-20 | University Of Kentucky Research Foundation | Halogenated diarylacetylenes and methods of treating cancer |
| WO2017070089A1 (en) | 2015-10-19 | 2017-04-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| ES2928856T3 (es) | 2015-11-19 | 2022-11-23 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| WO2017106634A1 (en) | 2015-12-17 | 2017-06-22 | Incyte Corporation | N-phenyl-pyridine-2-carboxamide derivatives and their use as pd-1/pd-l1 protein/protein interaction modulators |
| TWI850624B (zh) | 2015-12-22 | 2024-08-01 | 美商英塞特公司 | 作為免疫調節劑之雜環化合物 |
| ES2906460T3 (es) | 2016-05-06 | 2022-04-18 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| TW201808902A (zh) | 2016-05-26 | 2018-03-16 | 美商英塞特公司 | 作為免疫調節劑之雜環化合物 |
| PT3472167T (pt) | 2016-06-20 | 2022-11-11 | Incyte Corp | Compostos heterocíclicos como imunomoduladores |
| US20180016260A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| MA46045A (fr) | 2016-08-29 | 2021-04-28 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| EP3558973B1 (en) | 2016-12-22 | 2021-09-15 | Incyte Corporation | Pyridine derivatives as immunomodulators |
| RS63710B1 (sr) | 2016-12-22 | 2022-11-30 | Incyte Corp | Derivati tetrahidro imidazo[4,5-c] piridina kao induktori internalizacije pd-l1 |
| JP7101678B2 (ja) | 2016-12-22 | 2022-07-15 | インサイト・コーポレイション | 免疫調節剤としての複素環式化合物 |
| US20180179201A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| TW201835049A (zh) | 2016-12-22 | 2018-10-01 | 美商英塞特公司 | 作為免疫調節劑之雜環化合物 |
| RS66699B1 (sr) | 2018-03-30 | 2025-05-30 | Incyte Corp | Heterociklična jedinjenja kao imunomodulatori |
| TW202425987A (zh) | 2018-05-11 | 2024-07-01 | 美商英塞特公司 | 作為免疫調節劑之雜環化合物 |
| TW202115059A (zh) | 2019-08-09 | 2021-04-16 | 美商英塞特公司 | Ｐｄ—１／ｐｄ—ｌ１抑制劑之鹽 |
| JP7559059B2 (ja) | 2019-09-30 | 2024-10-01 | インサイト・コーポレイション | 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 |
| PH12022551136A1 (en) | 2019-11-11 | 2023-10-09 | Incyte Corp | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
| TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式 |
| TW202233616A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | 用於製備ｐｄ－１／ｐｄ－ｌ１抑制劑以及其鹽及結晶形式之方法 |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| CN113332435B (zh) * | 2021-06-18 | 2022-10-18 | 广州中医药大学(广州中医药研究院) | 鞘氨醇-1-磷酸4受体激动剂及其与真武汤联合在制备治疗慢性肾小球肾炎药物中的应用 |
| AR126733A1 (es) | 2021-08-10 | 2023-11-08 | Abbvie Inc | Inhibidores de nicotinamida ripk1 |
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| US4767896A (en) | 1985-09-03 | 1988-08-30 | Molex Incorporated | Stamped circuitry assembly |
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| HUT63941A (en) * | 1992-05-15 | 1993-11-29 | Hoechst Ag | Process for producing 4-alkyl-substituted pyrimidine-5-carboxanilide derivatives, and fungicidal compositions comprising same |
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-
2008
- 2008-09-19 US US12/234,514 patent/US8080542B2/en not_active Expired - Fee Related
- 2008-09-19 EP EP08831946A patent/EP2188252B1/en active Active
- 2008-09-19 ES ES08831946T patent/ES2360929T3/es active Active
- 2008-09-19 JP JP2010525834A patent/JP2010540438A/ja active Pending
- 2008-09-19 WO PCT/US2008/010887 patent/WO2009038759A2/en not_active Ceased
- 2008-09-19 DE DE602008006209T patent/DE602008006209D1/de active Active
- 2008-09-19 AT AT08831946T patent/ATE505454T1/de not_active IP Right Cessation
- 2008-09-19 AU AU2008302746A patent/AU2008302746B2/en not_active Ceased
- 2008-09-19 MX MX2010002885A patent/MX2010002885A/es active IP Right Grant
- 2008-09-19 CA CA2699417A patent/CA2699417A1/en not_active Abandoned
-
2011
- 2011-12-16 US US13/327,951 patent/US20120088749A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010002885A (es) | 2010-04-01 |
| JP2010540438A (ja) | 2010-12-24 |
| AU2008302746A1 (en) | 2009-03-26 |
| US8080542B2 (en) | 2011-12-20 |
| EP2188252B1 (en) | 2011-04-13 |
| AU2008302746B2 (en) | 2014-07-03 |
| EP2188252A2 (en) | 2010-05-26 |
| DE602008006209D1 (de) | 2011-05-26 |
| US20120088749A1 (en) | 2012-04-12 |
| US20090082331A1 (en) | 2009-03-26 |
| CA2699417A1 (en) | 2009-03-26 |
| WO2009038759A3 (en) | 2009-07-23 |
| ES2360929T3 (es) | 2011-06-10 |
| WO2009038759A2 (en) | 2009-03-26 |
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