ATE505208T1 - Rezeptorbindende konjugate - Google Patents

Rezeptorbindende konjugate

Info

Publication number
ATE505208T1
ATE505208T1 AT00980133T AT00980133T ATE505208T1 AT E505208 T1 ATE505208 T1 AT E505208T1 AT 00980133 T AT00980133 T AT 00980133T AT 00980133 T AT00980133 T AT 00980133T AT E505208 T1 ATE505208 T1 AT E505208T1
Authority
AT
Austria
Prior art keywords
receptor binding
present
conjugate
binding conjugates
prepare
Prior art date
Application number
AT00980133T
Other languages
English (en)
Inventor
Gjermund Henriksen
Roy Larsen
Original Assignee
Anticancer Therapeutic Inv S As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anticancer Therapeutic Inv S As filed Critical Anticancer Therapeutic Inv S As
Application granted granted Critical
Publication of ATE505208T1 publication Critical patent/ATE505208T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0493—Steroids, e.g. cholesterol, testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
AT00980133T 1999-12-06 2000-12-05 Rezeptorbindende konjugate ATE505208T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO19995978A NO314537B1 (no) 1999-12-06 1999-12-06 Reseptorbindende konjugater
PCT/NO2000/000413 WO2001039806A1 (en) 1999-12-06 2000-12-05 Receptor binding conjugates

Publications (1)

Publication Number Publication Date
ATE505208T1 true ATE505208T1 (de) 2011-04-15

Family

ID=19904060

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00980133T ATE505208T1 (de) 1999-12-06 2000-12-05 Rezeptorbindende konjugate

Country Status (11)

Country Link
US (3) US6740304B2 (de)
EP (1) EP1237584B1 (de)
JP (1) JP5153044B2 (de)
AT (1) ATE505208T1 (de)
AU (1) AU1743201A (de)
DE (1) DE60045847D1 (de)
DK (1) DK1237584T3 (de)
ES (1) ES2364811T3 (de)
NO (1) NO314537B1 (de)
PT (1) PT1237584E (de)
WO (1) WO2001039806A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO310544B1 (no) * 1999-01-04 2001-07-23 Algeta As Opparbeidelse og anvendelse av radium-223 til fremstilling av preparat samt kit til behandling av kalsifisert vev for palliasjon, benkreft-terapi og/eller overflatebehandling av ben
NO314537B1 (no) * 1999-12-06 2003-04-07 Anticancer Therapeutic Inv Sa Reseptorbindende konjugater
NO313180B1 (no) * 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
PL367102A1 (en) * 2001-05-02 2005-02-21 Purdue Research Foundation Treatment and diagnosis of macrophage mediated disease
US8043603B2 (en) 2002-02-07 2011-10-25 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8043602B2 (en) 2002-02-07 2011-10-25 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
GR1004274B (el) * 2002-07-16 2003-06-23 Medexis ���� Συμπλοκα στεροειδων ορμονων με πρωτεινες: νεες ουσιες για την ειδικη ανιχνευση και καταστροφη καρκινικων κυτταρων προερχομενων απο στερεους ογκους και αιματολογικες κακοηθειες
PL375363A1 (en) 2002-07-16 2005-11-28 Medexis S.A. Steroid conjugates, preparation thereof and the use thereof
GB0308731D0 (en) * 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy
EA008195B1 (ru) 2003-04-15 2007-04-27 Алгета Ас Применение тория-227 в лучевой терапии заболеваний мягких тканей
JP4680185B2 (ja) 2003-05-30 2011-05-11 パーデュー・リサーチ・ファウンデーション アテローム性動脈硬化症の診断法
CA2555435C (en) * 2004-02-20 2011-07-12 Algeta As Alpha-emitting hydroxyapatite particles
GB0423565D0 (en) * 2004-10-22 2004-11-24 Algeta As Formulation
CN101128152A (zh) * 2004-12-23 2008-02-20 普渡研究基金会 发射正电子段层成像方法
EP1904183B1 (de) 2005-07-05 2014-10-15 Purdue Research Foundation Pharmazeutische Zusammensetzung zur Behandlung von Arthrose
EP1940473A2 (de) 2005-09-23 2008-07-09 Purdue Research Foundation Verfahren und vorrichtung für die multiphotonen-in-vivo-durchflusszytometrie
WO2007143561A1 (en) * 2006-06-01 2007-12-13 Mayo Foundation For Medical Education And Research Immunity to folate receptors
EP2087337A4 (de) 2006-11-03 2010-09-08 Purdue Research Foundation Verfahren und vorrichtung für ex-vivo-durchflusszytometrie
EP2567711A3 (de) 2007-02-07 2013-05-01 Purdue Research Foundation Bildgebungsverfahren für Positronenemissionstomographie
WO2008148001A2 (en) 2007-05-25 2008-12-04 Purdue Research Foundation Method of imaging localized infections
CN101985471B (zh) * 2009-07-29 2014-04-30 上海汉升生物科技有限公司 叶酸-IgG偶联物及其制备方法与应用
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product
GB201122325D0 (en) 2011-12-23 2012-02-01 Cytoguide As Novel formulations
ES2843625T3 (es) 2014-06-18 2021-07-19 Alpha Therapy Solutions Ab Plataforma de proceso automático para la producción de radiofármacos marcados con astatina-211 [At-211]

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4336185A (en) * 1976-03-02 1982-06-22 Rohm And Haas Company Folic acid derivatives
DE3436177A1 (de) * 1984-10-03 1986-04-03 Goldschmidt Ag Th Verwendung von polyoxyalkylen-polysiloxan-copolymerisaten mit an siliciumatomen gebundenen langkettigen alkylresten als emulgatoren zur herstellung von w/o-emulsionen
NO881077L (no) 1987-03-11 1988-09-12 Univ Michigan Kjemo-radio-immuno-konjugater.
US5686578A (en) * 1994-08-05 1997-11-11 Immunomedics, Inc. Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
US5547668A (en) * 1995-05-05 1996-08-20 The Board Of Trustees Of The University Of Illinois Conjugates of folate anti-effector cell antibodies
CA2253904A1 (en) * 1996-05-03 1997-11-13 Immunomedics, Inc. Targeted combination immunotherapy of cancer
US6093382A (en) * 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
NO310544B1 (no) * 1999-01-04 2001-07-23 Algeta As Opparbeidelse og anvendelse av radium-223 til fremstilling av preparat samt kit til behandling av kalsifisert vev for palliasjon, benkreft-terapi og/eller overflatebehandling av ben
NO314537B1 (no) * 1999-12-06 2003-04-07 Anticancer Therapeutic Inv Sa Reseptorbindende konjugater
NO312708B1 (no) * 2000-02-21 2002-06-24 Anticancer Therapeutic Inv Sa Radioaktive liposomer til terapi
NO313180B1 (no) * 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
GB0213261D0 (en) * 2002-06-10 2002-07-17 Anticancer Therapeutic Inv Sa Method
US20060228297A1 (en) * 2003-04-15 2006-10-12 Roy Larsen Thorium-227 for use in radiotherapy of soft tissue disease
GB0308731D0 (en) * 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy

Also Published As

Publication number Publication date
JP2003515570A (ja) 2003-05-07
WO2001039806A1 (en) 2001-06-07
US6740304B2 (en) 2004-05-25
NO314537B1 (no) 2003-04-07
PT1237584E (pt) 2011-05-02
ES2364811T3 (es) 2011-09-14
EP1237584B1 (de) 2011-04-13
DK1237584T3 (da) 2011-07-18
US20040184990A1 (en) 2004-09-23
NO995978L (no) 2001-06-07
NO995978D0 (no) 1999-12-06
AU1743201A (en) 2001-06-12
US20150258223A1 (en) 2015-09-17
DE60045847D1 (de) 2011-05-26
US20010008625A1 (en) 2001-07-19
JP5153044B2 (ja) 2013-02-27
EP1237584A1 (de) 2002-09-11

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