ATE504938T1 - Laserdesorptions-elektrospray-ionenquelle für massenspektrometer - Google Patents

Laserdesorptions-elektrospray-ionenquelle für massenspektrometer

Info

Publication number
ATE504938T1
ATE504938T1 AT08747254T AT08747254T ATE504938T1 AT E504938 T1 ATE504938 T1 AT E504938T1 AT 08747254 T AT08747254 T AT 08747254T AT 08747254 T AT08747254 T AT 08747254T AT E504938 T1 ATE504938 T1 AT E504938T1
Authority
AT
Austria
Prior art keywords
ion source
mass spectrometer
sample
laser desorption
electrospray ion
Prior art date
Application number
AT08747254T
Other languages
English (en)
Inventor
Viatcheslav Kovtoun
Original Assignee
Thermo Finnigan Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermo Finnigan Llc filed Critical Thermo Finnigan Llc
Application granted granted Critical
Publication of ATE504938T1 publication Critical patent/ATE504938T1/de

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
AT08747254T 2007-05-03 2008-04-30 Laserdesorptions-elektrospray-ionenquelle für massenspektrometer ATE504938T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/799,910 US7525105B2 (en) 2007-05-03 2007-05-03 Laser desorption—electrospray ion (ESI) source for mass spectrometers
PCT/US2008/062106 WO2008137484A2 (en) 2007-05-03 2008-04-30 Laser desorption - electrospray ion (esi) source for mass spectrometers

Publications (1)

Publication Number Publication Date
ATE504938T1 true ATE504938T1 (de) 2011-04-15

Family

ID=39832314

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08747254T ATE504938T1 (de) 2007-05-03 2008-04-30 Laserdesorptions-elektrospray-ionenquelle für massenspektrometer

Country Status (6)

Country Link
US (1) US7525105B2 (de)
EP (1) EP2140478B1 (de)
AT (1) ATE504938T1 (de)
CA (1) CA2683985A1 (de)
DE (1) DE602008006054D1 (de)
WO (1) WO2008137484A2 (de)

Families Citing this family (40)

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DE102006056929B4 (de) * 2006-12-04 2010-09-02 Bruker Daltonik Gmbh Massenspektrometrie mit Laser-Ablation
US20100285446A1 (en) * 2007-07-20 2010-11-11 Akos Vertes Methods for Detecting Metabolic States by Laser Ablation Electrospray Ionization Mass Spectrometry
US8067730B2 (en) 2007-07-20 2011-11-29 The George Washington University Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry
US8901487B2 (en) * 2007-07-20 2014-12-02 George Washington University Subcellular analysis by laser ablation electrospray ionization mass spectrometry
US7964843B2 (en) 2008-07-18 2011-06-21 The George Washington University Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry
US7915579B2 (en) * 2008-09-05 2011-03-29 Ohio University Method and apparatus of liquid sample-desorption electrospray ionization-mass specrometry (LS-DESI-MS)
WO2010114976A1 (en) * 2009-04-01 2010-10-07 Prosolia, Inc. Method and system for surface sampling
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
US8704167B2 (en) 2009-04-30 2014-04-22 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
CA2759987C (en) * 2009-04-30 2018-10-02 Purdue Research Foundation Ion generation using wetted porous material
US20120006983A1 (en) * 2009-05-18 2012-01-12 Jeol Usa Inc. Method of surface ionization with solvent spray and excited-state neutrals
EP2467868A1 (de) * 2009-08-17 2012-06-27 Temple University Of The Commonwealth System Of Higher Education Verdampfungsvorrichtung und vorrichtung für bildgebende massenspektrometrie
GB2475742B (en) * 2009-11-30 2014-02-12 Microsaic Systems Plc Sample collection and detection system
US8097845B2 (en) 2010-03-11 2012-01-17 Battelle Memorial Institute Focused analyte spray emission apparatus and process for mass spectrometric analysis
WO2011140492A2 (en) 2010-05-07 2011-11-10 Ut-Battelle, Llc System and method for extracting a sample from a surface
US20140166875A1 (en) * 2010-09-02 2014-06-19 Wayne State University Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry
US8486703B2 (en) 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
US8519330B2 (en) 2010-10-01 2013-08-27 Ut-Battelle, Llc Systems and methods for laser assisted sample transfer to solution for chemical analysis
US8637813B2 (en) 2010-10-01 2014-01-28 Ut-Battelle, Llc System and method for laser assisted sample transfer to solution for chemical analysis
US8853621B2 (en) * 2010-10-25 2014-10-07 Wayne State University Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum
TWI510781B (zh) * 2010-10-29 2015-12-01 Scinopharm Taiwan Ltd 即時監測固相胜肽合成反應之質譜系統
WO2012094227A2 (en) 2011-01-05 2012-07-12 Purdue Research Foundation (Prf) Systems and methods for sample analysis
US9157921B2 (en) 2011-05-18 2015-10-13 Purdue Research Foundation Method for diagnosing abnormality in tissue samples by combination of mass spectral and optical imaging
US9546979B2 (en) 2011-05-18 2017-01-17 Purdue Research Foundation Analyzing a metabolite level in a tissue sample using DESI
US8895918B2 (en) 2011-06-03 2014-11-25 Purdue Research Foundation Ion generation using modified wetted porous materials
EP2732457A4 (de) 2011-07-14 2015-09-16 Univ George Washington Abgaskollimation für eine massenspektrometrie mit laserablations-elektrospray-ionisation
US8648297B2 (en) 2011-07-21 2014-02-11 Ohio University Coupling of liquid chromatography with mass spectrometry by liquid sample desorption electrospray ionization (DESI)
US8664589B2 (en) * 2011-12-29 2014-03-04 Electro Scientific Industries, Inc Spectroscopy data display systems and methods
EP2948974A2 (de) * 2013-01-28 2015-12-02 Westfälische Wilhelms-Universität Münster Massenspektrometrie mit laserablations-atmosphärendruckionisation
EP3742472A1 (de) 2013-01-31 2020-11-25 Purdue Research Foundation Methoden zur analyse einer entnommenen probe
CA2888351A1 (en) 2013-01-31 2014-08-07 Purdue Research Foundation Methods of analyzing crude oil
EP3486937B1 (de) 2013-06-25 2022-07-27 Purdue Research Foundation Massenspektrometrieanalyse von mikroorganismen in proben
US11293872B2 (en) 2014-09-18 2022-04-05 Universiteit Gent Laser ablation probe
US9390901B2 (en) * 2014-10-31 2016-07-12 Ut-Battelle, Llc System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis
US9786478B2 (en) 2014-12-05 2017-10-10 Purdue Research Foundation Zero voltage mass spectrometry probes and systems
JP6948266B2 (ja) 2015-02-06 2021-10-13 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ プローブ、システム、カートリッジ、およびその使用方法
US9632066B2 (en) 2015-04-09 2017-04-25 Ut-Battelle, Llc Open port sampling interface
US10060838B2 (en) 2015-04-09 2018-08-28 Ut-Battelle, Llc Capture probe
US11125657B2 (en) 2018-01-30 2021-09-21 Ut-Battelle, Llc Sampling probe
CN110416059B (zh) 2018-04-27 2020-09-11 岛津分析技术研发（上海）有限公司 样本解吸及电离装置以及应用该装置的质谱仪及分析方法

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Publication number Priority date Publication date Assignee Title
DE10158860B4 (de) 2001-11-30 2007-04-05 Bruker Daltonik Gmbh Massenspektrometrische Proteingemischanalyse
DE102004002729B4 (de) 2004-01-20 2008-11-27 Bruker Daltonik Gmbh Ionisierung desorbierter Analytmoleküle bei Atmosphärendruck
US7335897B2 (en) * 2004-03-30 2008-02-26 Purdue Research Foundation Method and system for desorption electrospray ionization
TWI271771B (en) * 2006-01-27 2007-01-21 Univ Nat Sun Yat Sen Electrospray-assisted laser desorption ionization devices, mass spectrometers, and methods for mass spectrometry

Also Published As

Publication number Publication date
DE602008006054D1 (de) 2011-05-19
WO2008137484A2 (en) 2008-11-13
US20080272294A1 (en) 2008-11-06
CA2683985A1 (en) 2008-11-13
EP2140478A2 (de) 2010-01-06
WO2008137484A3 (en) 2009-08-06
EP2140478B1 (de) 2011-04-06
US7525105B2 (en) 2009-04-28

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