ATE49T1 - PRODUCTION OF 1-DESOXY-NOJIRIMYCIN AND N-SUBSTITUTED DERIVATIVES. - Google Patents
PRODUCTION OF 1-DESOXY-NOJIRIMYCIN AND N-SUBSTITUTED DERIVATIVES.Info
- Publication number
- ATE49T1 ATE49T1 AT79102174T AT79102174T ATE49T1 AT E49 T1 ATE49 T1 AT E49T1 AT 79102174 T AT79102174 T AT 79102174T AT 79102174 T AT79102174 T AT 79102174T AT E49 T1 ATE49 T1 AT E49T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- image
- nojirimycin
- desoxy
- substituted derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention relates to a process for the production of a compound of the formula <IMAGE> (I) in which R denotes a hydrogen atom or an alkyl, aralkyl or aryl group and comprises deblocking a compound of the general formula <IMAGE> +TR <IMAGE> in which R has the meaning indicated above, by treatment with a strong mineral acid and isolating the intermediate product in the form of a salt thereof and then hydrogenating said salt with a suitable hydrogen donor, or, in a one-pot process, first deblocking the starting material by treatment with a strong mineral acid and, after controlled addition of a base, hydrogenating directly.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782830469 DE2830469A1 (en) | 1978-07-11 | 1978-07-11 | PRODUCTION OF L-DESOXY-NOJIRIMYCIN AND N-SUBSTITUTED DERIVATIVES |
EP79102174A EP0007040B1 (en) | 1978-07-11 | 1979-06-29 | Process for the preparation of 1-desoxy-nojirimicyn and n-substituted derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE49T1 true ATE49T1 (en) | 1981-05-15 |
Family
ID=6044098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT79102174T ATE49T1 (en) | 1978-07-11 | 1979-06-29 | PRODUCTION OF 1-DESOXY-NOJIRIMYCIN AND N-SUBSTITUTED DERIVATIVES. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4220782A (en) |
EP (1) | EP0007040B1 (en) |
JP (1) | JPS5513286A (en) |
AT (1) | ATE49T1 (en) |
CA (1) | CA1113100A (en) |
DE (2) | DE2830469A1 (en) |
DK (1) | DK154831C (en) |
ES (1) | ES482365A1 (en) |
IL (1) | IL57752A (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4307194A (en) * | 1976-12-23 | 1981-12-22 | Bayer Aktiengesellschaft | Inhibitors, obtained from bacilli, for glycoside hydrolases |
NO154918C (en) * | 1977-08-27 | 1987-01-14 | Bayer Ag | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE DERIVATIVES OF 3,4,5-TRIHYDROXYPIPERIDINE. |
DE2853573A1 (en) * | 1978-12-12 | 1980-07-03 | Bayer Ag | PREPARATION OF N-SUBSTITUTED DERIVATIVES OF L-DESOXYNOJIRIMYCIN |
DE2925943A1 (en) * | 1979-06-27 | 1981-01-29 | Bayer Ag | 1-ALKADIEN-2,4-YL-2-HYDROXYMETHYL3,4,5-TRIHYDROXYPIPERIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT |
DE2936240A1 (en) * | 1979-09-07 | 1981-03-26 | Bayer Ag, 51373 Leverkusen | METHOD FOR THE PRODUCTION OF KNOWN AND NEW 6-AMINO-6-DESOXY-2,3-0-ISOPROPYLIDEN- (ALPHA) -L-SORBOFURANOSE DERIVATIVES AND NEW INTERMEDIATE PRODUCTS OF THE METHOD |
JPS56108767A (en) * | 1980-01-28 | 1981-08-28 | Nippon Shinyaku Co Ltd | Bismoranoline derivative |
JPS56108768A (en) * | 1980-01-28 | 1981-08-28 | Nippon Shinyaku Co Ltd | Cinnamylmoranoline derivative |
DE3038901A1 (en) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING N-SUBSTITUTED DERIVATIVES OF 1-DESOXYNOJIRIMYCIN |
DE3049446A1 (en) * | 1980-12-30 | 1982-07-29 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING 1,5-DIDESOXY-1,5-IMINO-D-GLUCITOL AND ITS N-DERIVATIVES |
DE3620645A1 (en) * | 1985-12-20 | 1987-07-02 | Bayer Ag | 3-AMINO-4,5-DIHYDROXYPIPERIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF |
EP0344383A1 (en) * | 1988-06-02 | 1989-12-06 | Merrell Dow Pharmaceuticals Inc. | Novel alpha-Glucosidase inhibitors |
US5298494A (en) * | 1989-01-09 | 1994-03-29 | Greenwich Pharmaceuticals Incorporated | Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof |
US4996195A (en) * | 1989-01-09 | 1991-02-26 | Greenwich Pharmaceuticals Inc. | Derivatives of α,D-glucofuranose or α,D-allofuranose and intermediates for preparing these derivatives |
US5010058A (en) * | 1989-06-22 | 1991-04-23 | 501 Greenwich Pharmaceuticals Incorporated | 3,5,6-substituted derivatives of 1,2-O-isopropylidene-α,D-glucofuranose and intermediates for preparing these derivatives |
US5030638A (en) * | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
US5151519A (en) * | 1990-05-07 | 1992-09-29 | G. D. Searle & Co. | Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof |
US5504078A (en) * | 1990-06-08 | 1996-04-02 | Merrell Dow Pharmaceuticals Inc. | α-glucosidase inhibitors |
JPH08226826A (en) | 1995-02-22 | 1996-09-03 | Mikuni Corp | Magnetic position sensor |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
JPS5282710A (en) * | 1975-12-29 | 1977-07-11 | Nippon Shinyaku Co Ltd | Extraction of effective drug component from mulberry |
DE2738717A1 (en) * | 1977-08-27 | 1979-03-08 | Bayer Ag | Tri:hydroxy-piperidine derivs. - useful as glucosidase inhibitors for treating diabetes etc. and as animal feed additives |
GB2009152B (en) * | 1977-11-10 | 1982-01-06 | Nippon Shinyaku Co Ltd | Method for producing moranoline and n-methylmoranoline |
-
1978
- 1978-07-11 DE DE19782830469 patent/DE2830469A1/en not_active Withdrawn
-
1979
- 1979-06-21 US US06/050,907 patent/US4220782A/en not_active Expired - Lifetime
- 1979-06-29 AT AT79102174T patent/ATE49T1/en not_active IP Right Cessation
- 1979-06-29 EP EP79102174A patent/EP0007040B1/en not_active Expired
- 1979-06-29 DE DE7979102174T patent/DE2960308D1/en not_active Expired
- 1979-07-09 IL IL57752A patent/IL57752A/en not_active IP Right Cessation
- 1979-07-09 JP JP8602679A patent/JPS5513286A/en active Granted
- 1979-07-09 CA CA331,437A patent/CA1113100A/en not_active Expired
- 1979-07-10 DK DK290779A patent/DK154831C/en not_active IP Right Cessation
- 1979-07-10 ES ES482365A patent/ES482365A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DK154831B (en) | 1988-12-27 |
JPS6241502B2 (en) | 1987-09-03 |
DE2830469A1 (en) | 1980-01-24 |
CA1113100A (en) | 1981-11-24 |
DK154831C (en) | 1989-05-16 |
IL57752A0 (en) | 1979-11-30 |
ES482365A1 (en) | 1980-04-01 |
EP0007040B1 (en) | 1981-04-29 |
US4220782A (en) | 1980-09-02 |
EP0007040A1 (en) | 1980-01-23 |
IL57752A (en) | 1982-04-30 |
DE2960308D1 (en) | 1981-08-06 |
JPS5513286A (en) | 1980-01-30 |
DK290779A (en) | 1980-01-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REN | Ceased due to non-payment of the annual fee |