ATE496896T1 - 1h-imidazolderivate als modulatoren des cannabinoidrezeptors - Google Patents
1h-imidazolderivate als modulatoren des cannabinoidrezeptorsInfo
- Publication number
- ATE496896T1 ATE496896T1 AT04791252T AT04791252T ATE496896T1 AT E496896 T1 ATE496896 T1 AT E496896T1 AT 04791252 T AT04791252 T AT 04791252T AT 04791252 T AT04791252 T AT 04791252T AT E496896 T1 ATE496896 T1 AT E496896T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazole derivatives
- modulators
- cannabinoid receptor
- compounds
- preparation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51210503P | 2003-10-20 | 2003-10-20 | |
EP03103867 | 2003-10-20 | ||
PCT/EP2004/052575 WO2005040130A1 (en) | 2003-10-20 | 2004-10-19 | 1h-imidazole derivatives as cannabinoid receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE496896T1 true ATE496896T1 (de) | 2011-02-15 |
Family
ID=34524747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04791252T ATE496896T1 (de) | 2003-10-20 | 2004-10-19 | 1h-imidazolderivate als modulatoren des cannabinoidrezeptors |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1675833B1 (de) |
JP (1) | JP2007509048A (de) |
KR (1) | KR20060117952A (de) |
AT (1) | ATE496896T1 (de) |
AU (1) | AU2004283903B2 (de) |
BR (1) | BRPI0414511A (de) |
CA (1) | CA2534824A1 (de) |
DE (1) | DE602004031245D1 (de) |
IL (1) | IL173436A (de) |
MX (1) | MXPA06002064A (de) |
NO (1) | NO20062249L (de) |
RU (1) | RU2337907C2 (de) |
WO (1) | WO2005040130A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200528102A (en) * | 2003-10-24 | 2005-09-01 | Solvay Pharm Gmbh | Novel medical combination treatment of obesity involving 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity |
CA2594488C (en) * | 2005-01-10 | 2015-04-28 | University Of Connecticut | Novel heteropyrrole analogs acting on cannabinoid receptors |
ATE479435T1 (de) | 2006-04-14 | 2010-09-15 | Merck Sharp & Dohme | Substituierte imidazol-4-carboxamide als cholecystokinin-1-rezeptor-modulatoren |
RU2008144962A (ru) | 2006-04-14 | 2010-05-20 | Мерк энд Ко., Инк. (US) | Замещенные имидазол-4-карбоксамиды в качестве модуляторов рецепторов холецистокина-1 |
US7759352B2 (en) | 2006-04-14 | 2010-07-20 | Merck Sharp & Dohme Corp. | Substituted imidazole-4-carboxamides as cholecystokinin-1 receptor modulators |
CA2676222A1 (en) | 2007-01-26 | 2008-07-31 | Merck & Co., Inc. | Substituted aminopyrimidines as cholecystokinin-1 receptor modulators |
WO2010079241A1 (es) | 2009-01-12 | 2010-07-15 | Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion | Uso de antagonistas y/o agonistas inversos de los receptores cb1 para la preparación de medicamentos que incrementen la excitabilidad de las motoneuronas |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI231757B (en) * | 2001-09-21 | 2005-05-01 | Solvay Pharm Bv | 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity |
US20040248956A1 (en) * | 2002-01-29 | 2004-12-09 | Hagmann William K | Substituted imidazoles as cannabinoid receptor modulators |
US7145012B2 (en) * | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
-
2004
- 2004-10-19 RU RU2006113197/04A patent/RU2337907C2/ru not_active IP Right Cessation
- 2004-10-19 EP EP04791252A patent/EP1675833B1/de active Active
- 2004-10-19 MX MXPA06002064A patent/MXPA06002064A/es active IP Right Grant
- 2004-10-19 CA CA002534824A patent/CA2534824A1/en not_active Abandoned
- 2004-10-19 JP JP2006534770A patent/JP2007509048A/ja not_active Ceased
- 2004-10-19 DE DE602004031245T patent/DE602004031245D1/de active Active
- 2004-10-19 KR KR1020067009684A patent/KR20060117952A/ko not_active Application Discontinuation
- 2004-10-19 BR BRPI0414511-9A patent/BRPI0414511A/pt not_active IP Right Cessation
- 2004-10-19 WO PCT/EP2004/052575 patent/WO2005040130A1/en active Application Filing
- 2004-10-19 AU AU2004283903A patent/AU2004283903B2/en not_active Ceased
- 2004-10-19 AT AT04791252T patent/ATE496896T1/de not_active IP Right Cessation
-
2006
- 2006-01-30 IL IL173436A patent/IL173436A/en not_active IP Right Cessation
- 2006-05-18 NO NO20062249A patent/NO20062249L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2007509048A (ja) | 2007-04-12 |
EP1675833B1 (de) | 2011-01-26 |
DE602004031245D1 (de) | 2011-03-10 |
IL173436A0 (en) | 2006-06-11 |
CA2534824A1 (en) | 2005-05-06 |
WO2005040130A1 (en) | 2005-05-06 |
BRPI0414511A (pt) | 2006-11-07 |
MXPA06002064A (es) | 2006-05-19 |
AU2004283903A1 (en) | 2005-05-06 |
RU2337907C2 (ru) | 2008-11-10 |
IL173436A (en) | 2011-01-31 |
RU2006113197A (ru) | 2006-09-10 |
KR20060117952A (ko) | 2006-11-17 |
NO20062249L (no) | 2006-07-11 |
AU2004283903B2 (en) | 2010-12-02 |
EP1675833A1 (de) | 2006-07-05 |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |