ATE494276T1 - 2,3,4-substituierte cyclopentanone als therapeutische wirkstoffe - Google Patents
2,3,4-substituierte cyclopentanone als therapeutische wirkstoffeInfo
- Publication number
- ATE494276T1 ATE494276T1 AT05848155T AT05848155T ATE494276T1 AT E494276 T1 ATE494276 T1 AT E494276T1 AT 05848155 T AT05848155 T AT 05848155T AT 05848155 T AT05848155 T AT 05848155T AT E494276 T1 ATE494276 T1 AT E494276T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- active ingredients
- therapeutic active
- functional group
- carbon atoms
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/991,284 US7101906B2 (en) | 2004-11-16 | 2004-11-16 | 2,3,4-substituted cyclopentanones as therapeutic agents |
| PCT/US2005/041171 WO2006055481A1 (en) | 2004-11-16 | 2005-11-14 | 2,3,4-substituted cyclopentanones as therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE494276T1 true ATE494276T1 (de) | 2011-01-15 |
Family
ID=36072191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05848155T ATE494276T1 (de) | 2004-11-16 | 2005-11-14 | 2,3,4-substituierte cyclopentanone als therapeutische wirkstoffe |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7101906B2 (de) |
| EP (1) | EP1812387B1 (de) |
| AT (1) | ATE494276T1 (de) |
| AU (1) | AU2005306656B2 (de) |
| CA (1) | CA2588056C (de) |
| DE (1) | DE602005025794D1 (de) |
| ES (1) | ES2357545T3 (de) |
| WO (1) | WO2006055481A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050222094A1 (en) * | 2001-06-14 | 2005-10-06 | Burk Robert M | Treatment of inflammatory bowel disease |
| US7872045B2 (en) | 2001-06-14 | 2011-01-18 | Allergan, Inc. | Combination therapy for glaucoma treatment |
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US7183324B2 (en) * | 2004-11-23 | 2007-02-27 | Allergan, Inc. | 2,3,4-substituted cyclopentanones as therapeutic agents |
| US7427685B2 (en) * | 2005-12-06 | 2008-09-23 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US7585895B2 (en) * | 2005-12-06 | 2009-09-08 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US20070232660A1 (en) * | 2006-04-04 | 2007-10-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| BRPI0811306A2 (pt) | 2007-05-08 | 2015-01-27 | Nat Univ Corp Hamamatsu | Ativador de célula t citotóxica compreendendo agonista ep4 |
| US8394793B2 (en) * | 2008-06-23 | 2013-03-12 | Nippon Shinyaku Co., Ltd. | Therapeutic agent for inflammatory bowel disease |
| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| JP2013508282A (ja) | 2009-10-14 | 2013-03-07 | ジェンムス ファーマ インコーポレイティド | ウイルス感染のための併用療法処置 |
| EP3884935B1 (de) | 2013-08-09 | 2023-06-14 | Ardelyx, Inc. | Verbindungen und verfahren zur hemmung eines phosphattransports |
| EP4046628A1 (de) | 2013-10-31 | 2022-08-24 | Allergan, Inc. | Prostamidhaltige intraokulare implantate und verfahren zur verwendung davon |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4154949A (en) * | 1974-12-11 | 1979-05-15 | Pfizer Inc. | 11-Desoxy-15-substituted-ω-pentanor prostaglandins |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| DE2715838A1 (de) | 1977-04-05 | 1978-10-19 | Schering Ag | Neue prostanderivate und verfahren zu ihrer herstellung |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4131738A (en) | 1977-07-05 | 1978-12-26 | The Upjohn Company | 6-Hydroxy-PGE1 compounds |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US5703108A (en) | 1996-02-28 | 1997-12-30 | Pfizer Inc. | Bone deposition by certain prostaglandin agonists |
| EP1114816A4 (de) | 1998-09-14 | 2002-09-04 | Ono Pharmaceutical Co | $g(v)-SUBSTITUIERTE PHENYL-PROSTAGLANDIN-E-DERIVATE UND SIE ALS AKTIVEN BESTANDTEIL ENTHALTENDE MEDIKAMENTE |
| KR20030053063A (ko) | 2000-11-27 | 2003-06-27 | 화이자 프로덕츠 인코포레이티드 | 골다공증 치료용 이피4 수용체 선택성 작용제 |
| US6531504B2 (en) | 2001-05-17 | 2003-03-11 | Allergan, Inc. | Prostanoic acid derivatives as agents for lowering intraocular pressure |
| CA2450466C (en) | 2001-06-14 | 2011-07-05 | Allergan, Inc. | 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
| JP2005514378A (ja) | 2001-12-03 | 2005-05-19 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症の治療方法 |
| US6875787B2 (en) | 2003-02-11 | 2005-04-05 | Allergan, Inc. | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
-
2004
- 2004-11-16 US US10/991,284 patent/US7101906B2/en active Active
-
2005
- 2005-11-14 WO PCT/US2005/041171 patent/WO2006055481A1/en active Application Filing
- 2005-11-14 EP EP05848155A patent/EP1812387B1/de not_active Not-in-force
- 2005-11-14 CA CA2588056A patent/CA2588056C/en not_active Expired - Fee Related
- 2005-11-14 AT AT05848155T patent/ATE494276T1/de not_active IP Right Cessation
- 2005-11-14 ES ES05848155T patent/ES2357545T3/es active Active
- 2005-11-14 AU AU2005306656A patent/AU2005306656B2/en not_active Ceased
- 2005-11-14 DE DE602005025794T patent/DE602005025794D1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20060106088A1 (en) | 2006-05-18 |
| WO2006055481A1 (en) | 2006-05-26 |
| DE602005025794D1 (en) | 2011-02-17 |
| AU2005306656A1 (en) | 2006-05-26 |
| CA2588056A1 (en) | 2006-05-26 |
| EP1812387B1 (de) | 2011-01-05 |
| AU2005306656B2 (en) | 2012-08-09 |
| US7101906B2 (en) | 2006-09-05 |
| ES2357545T3 (es) | 2011-04-27 |
| CA2588056C (en) | 2014-06-03 |
| EP1812387A1 (de) | 2007-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE494276T1 (de) | 2,3,4-substituierte cyclopentanone als therapeutische wirkstoffe | |
| AU2018255621A1 (en) | Apoptosis-inducing agents | |
| RS52163B (en) | DERIVATES THE BICYCLESTER | |
| WO2006049835A3 (en) | Indole and benzimidazole derivatives | |
| ATE540932T1 (de) | Hydantoin-derivate als antibakterielle wirkstoffe | |
| RS52214B (en) | HDAC INHIBITOR PHARMACEUTICAL FORMULATIONS | |
| EA200802288A1 (ru) | Замещенные имидазолы, композиция на их основе, способ профилактики или лечения нежелательного тромбообразования с их помощью и способ ингибирования коагуляции образцов крови | |
| TW200612958A (en) | Substituted imidazole derivatives | |
| NO20065613L (no) | 3-karbamoyl-2-pyridonderivat. | |
| WO2009102460A3 (en) | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | |
| DE602004008098D1 (de) | Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren | |
| MXPA97004127A (es) | Nuevos derivados de bencimidazol con actividad antihistaminica. | |
| EA201100698A1 (ru) | Производные тиенотриазолодиазепина, активные в отношении апо а1 | |
| DE60325830D1 (de) | Substituiertes phenylalkansäurederivat und dessen verwendung | |
| TN2009000287A1 (en) | Cyclized derivatives as eg-5inhibitors | |
| EA200500240A1 (ru) | Новый способ синтеза соединений 1,3,4,5-тетрагидро-2h-3-бензазепин-2-она и применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой | |
| WO2013096496A3 (en) | Compounds acting at multiple prostaglandin receptors giving a general anti-inflammatory response | |
| DK1753723T3 (da) | Substituerede quinolinderivater som mitotiske kinesininhibitorer | |
| EA200700103A1 (ru) | НОВЫЕ 2-ЗАМЕЩЁННЫЕ D-ГОМО-ЭСТРА-1,3,5(10)-ТРИЕНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ 17β-ГИДРОКСИСТЕРОИДДЕГИДРОГЕНАЗЫ ТИПА 1 | |
| AU2004243443A1 (en) | Nitrooxyderivatives of fluvastatin, pravastatin, cerivastatin, atorvastatin and rosuvastatin as cholesterol-reducing agents with improved anti-inflammatory, antithrombotic and antiplatelet activity | |
| JP2010500976A5 (de) | ||
| MY140325A (en) | Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them | |
| MX2009011449A (es) | Agente terapeutico o profilactico para disquinesia. | |
| CA2693627C (en) | Short acting phenylalkylamine calcium channel blockers and uses thereof | |
| NZ599268A (en) | Pharmaceutical compositions of rhein or diacerein made by wet granulation process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |