ATE491685T1 - 5-(heterocyclyl)alkyl-n- (arylsulfonyl)indolverbindungen und ihre verwendung als 5-ht6-liganden - Google Patents
5-(heterocyclyl)alkyl-n- (arylsulfonyl)indolverbindungen und ihre verwendung als 5-ht6-ligandenInfo
- Publication number
- ATE491685T1 ATE491685T1 AT07827525T AT07827525T ATE491685T1 AT E491685 T1 ATE491685 T1 AT E491685T1 AT 07827525 T AT07827525 T AT 07827525T AT 07827525 T AT07827525 T AT 07827525T AT E491685 T1 ATE491685 T1 AT E491685T1
- Authority
- AT
- Austria
- Prior art keywords
- disorders
- compounds
- pharmaceutically acceptable
- arylsulfonyl
- heterocyclyl
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 108091005435 5-HT6 receptors Proteins 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 201000011529 cardiovascular cancer Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 208000014001 urinary system disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN45CH2007 | 2007-01-08 | ||
| PCT/IN2007/000312 WO2008084492A1 (en) | 2007-01-08 | 2007-07-26 | 5-(heterocyclyl)alkyl-n-(arylsulfonyl)indole compounds and their use as 5-ht6 ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE491685T1 true ATE491685T1 (de) | 2011-01-15 |
Family
ID=39495814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07827525T ATE491685T1 (de) | 2007-01-08 | 2007-07-26 | 5-(heterocyclyl)alkyl-n- (arylsulfonyl)indolverbindungen und ihre verwendung als 5-ht6-liganden |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8470830B2 (de) |
| EP (1) | EP2114878B1 (de) |
| JP (1) | JP2010515674A (de) |
| KR (1) | KR101103023B1 (de) |
| CN (1) | CN101553467B (de) |
| AT (1) | ATE491685T1 (de) |
| AU (1) | AU2007343063B2 (de) |
| BR (1) | BRPI0718737A2 (de) |
| CA (1) | CA2670717C (de) |
| CY (1) | CY1111105T1 (de) |
| DE (1) | DE602007011323D1 (de) |
| DK (1) | DK2114878T3 (de) |
| EA (1) | EA017007B1 (de) |
| ES (1) | ES2357584T3 (de) |
| IL (1) | IL198821A (de) |
| MX (1) | MX2009006077A (de) |
| NO (1) | NO341713B1 (de) |
| NZ (1) | NZ577769A (de) |
| PL (1) | PL2114878T3 (de) |
| PT (1) | PT2114878E (de) |
| WO (1) | WO2008084492A1 (de) |
| ZA (1) | ZA200903600B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8318725B2 (en) | 2008-09-17 | 2012-11-27 | Suven Life Sciences Limited | Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands |
| CN103304547A (zh) * | 2012-03-13 | 2013-09-18 | 中国药科大学 | 一种抗抑郁药维拉唑酮的制备方法 |
| WO2015074123A1 (en) * | 2013-11-25 | 2015-05-28 | Novogen ltd | Functionalised and substituted indoles as anti-cancer agents |
| WO2015090233A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
| EP3166924B1 (de) * | 2014-07-08 | 2019-02-20 | Sunshine Lake Pharma Co., Ltd. | Aromatische heterocyclische derivate und pharmazeutische anwendungen davon |
| WO2016008011A1 (en) * | 2014-07-16 | 2016-01-21 | Novogen ltd | Functionalised and substituted indoles as anti-cancer agents |
| CN116096715A (zh) * | 2020-07-06 | 2023-05-09 | 泰科根公司 | 用于精神障碍或精神增强的有益苯并噻吩组合物 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9026389D0 (en) * | 1990-12-05 | 1991-01-23 | Merck Sharp & Dohme | Therapeutic agents |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| HUP0003073A3 (en) | 1997-07-11 | 2002-10-28 | Smithkline Beecham Plc | Benzenesulfonamide derivatives, process for producing them and their use as medicines |
| GB9801392D0 (en) | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| GB9803411D0 (en) | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
| ES2291024T4 (es) | 1999-04-21 | 2009-03-01 | Nps Allelix Corp. | Compuestos de piperidina-indol con afinidad con 5-ht6. |
| GB9926302D0 (en) | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| BR0115102B1 (pt) * | 2000-11-02 | 2013-11-26 | Compostos 1-aril- ou 1-alquilsulfonil-heterociclilbenzazóis e composição compreendendo os mesmos | |
| MXPA03006605A (es) | 2001-01-30 | 2003-09-22 | Lilly Co Eli | Esteres de indol-5-ilo del acido bencensulfonico como antagonistas del receptor 5-ht6. |
| EP1383767A1 (de) | 2001-02-08 | 2004-01-28 | Memory Pharmaceutical Corporation | Trifluormethylpurine als phosphodiesterase-4-hemmer |
| PL367305A1 (en) | 2001-06-07 | 2005-02-21 | F.Hoffmann-La Roche Ag | New indole derivatives with 5-ht6 receptor affinity |
| JP2005527463A (ja) * | 2001-08-07 | 2005-09-15 | スミスクライン ビーチャム パブリック リミテッド カンパニー | Ｃｎｓ疾患を治療するための５−ｈｔ６受容体アフィニティーを有する３−アリールスルホニル−７−ピペラジニル−インドール、−ベンゾフランおよび−ベンゾチオフェン |
| AU2003238339A1 (en) | 2002-02-01 | 2003-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with a new human 5-ht6 receptor |
| EP1471912A1 (de) | 2002-02-05 | 2004-11-03 | Glaxo Group Limited | Verfahren zur förderung des neuronenwachstums |
| SI1497266T1 (sl) | 2002-03-27 | 2008-10-31 | Glaxo Group Ltd | Derivati kinolina in njihova uporaba kot ligandi 5-ht6 |
| AU2003292508A1 (en) | 2002-11-28 | 2004-06-18 | Suven Life Sciences Limited | N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands |
| PT1567492E (pt) | 2002-11-28 | 2013-07-22 | Suven Life Sciences Ltd | N-arilsulfonil-3-aminoalcoxi-indóis |
| US7875605B2 (en) | 2002-11-28 | 2011-01-25 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| SI1581538T1 (sl) | 2002-12-18 | 2007-08-31 | Suven Life Sciences Ltd | Tetraciklični 3-substituirani indoli z afiniteto za receptor serotonina |
| WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
| ES2222828B1 (es) * | 2003-07-30 | 2006-04-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. |
| PT1919896E (pt) | 2005-08-12 | 2010-02-26 | Suven Life Sciences Ltd | Derivados de aminoaril sulfonamida como ligandos funcionais de 5-ht6 |
| AU2007271188B2 (en) * | 2006-07-03 | 2012-11-01 | Proximagen Limited | Indoles as 5-HT6 modulators |
-
2007
- 2007-07-26 MX MX2009006077A patent/MX2009006077A/es active IP Right Grant
- 2007-07-26 AT AT07827525T patent/ATE491685T1/de active
- 2007-07-26 WO PCT/IN2007/000312 patent/WO2008084492A1/en not_active Ceased
- 2007-07-26 EA EA200970675A patent/EA017007B1/ru not_active IP Right Cessation
- 2007-07-26 DK DK07827525.2T patent/DK2114878T3/da active
- 2007-07-26 JP JP2009544495A patent/JP2010515674A/ja active Pending
- 2007-07-26 EP EP07827525A patent/EP2114878B1/de active Active
- 2007-07-26 AU AU2007343063A patent/AU2007343063B2/en not_active Ceased
- 2007-07-26 NZ NZ577769A patent/NZ577769A/en not_active IP Right Cessation
- 2007-07-26 ES ES07827525T patent/ES2357584T3/es active Active
- 2007-07-26 CN CN2007800454515A patent/CN101553467B/zh not_active Expired - Fee Related
- 2007-07-26 KR KR1020097011686A patent/KR101103023B1/ko not_active Expired - Fee Related
- 2007-07-26 BR BRPI0718737-8A2A patent/BRPI0718737A2/pt not_active Application Discontinuation
- 2007-07-26 DE DE602007011323T patent/DE602007011323D1/de active Active
- 2007-07-26 PL PL07827525T patent/PL2114878T3/pl unknown
- 2007-07-26 PT PT07827525T patent/PT2114878E/pt unknown
- 2007-07-26 CA CA2670717A patent/CA2670717C/en not_active Expired - Fee Related
- 2007-07-26 US US12/521,967 patent/US8470830B2/en not_active Expired - Fee Related
-
2009
- 2009-05-19 IL IL198821A patent/IL198821A/en active IP Right Grant
- 2009-05-25 ZA ZA200903600A patent/ZA200903600B/xx unknown
- 2009-05-27 NO NO20092067A patent/NO341713B1/no not_active IP Right Cessation
-
2011
- 2011-01-13 CY CY20111100042T patent/CY1111105T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1132273A1 (en) | 2010-02-19 |
| JP2010515674A (ja) | 2010-05-13 |
| NZ577769A (en) | 2011-01-28 |
| WO2008084492A1 (en) | 2008-07-17 |
| CN101553467B (zh) | 2011-12-07 |
| EP2114878A1 (de) | 2009-11-11 |
| US8470830B2 (en) | 2013-06-25 |
| IL198821A0 (en) | 2010-02-17 |
| AU2007343063B2 (en) | 2011-02-17 |
| EA200970675A1 (ru) | 2009-12-30 |
| MX2009006077A (es) | 2009-06-17 |
| PL2114878T3 (pl) | 2011-05-31 |
| EA017007B1 (ru) | 2012-09-28 |
| ZA200903600B (en) | 2010-07-28 |
| CY1111105T1 (el) | 2015-06-11 |
| US20100041673A1 (en) | 2010-02-18 |
| NO20092067L (no) | 2009-09-04 |
| AU2007343063A8 (en) | 2009-07-23 |
| IL198821A (en) | 2014-11-30 |
| CA2670717A1 (en) | 2008-07-17 |
| CA2670717C (en) | 2012-01-10 |
| KR101103023B1 (ko) | 2012-01-05 |
| DE602007011323D1 (de) | 2011-01-27 |
| NO341713B1 (no) | 2018-01-08 |
| KR20090080544A (ko) | 2009-07-24 |
| CN101553467A (zh) | 2009-10-07 |
| PT2114878E (pt) | 2011-03-10 |
| AU2007343063A1 (en) | 2008-07-17 |
| ES2357584T3 (es) | 2011-04-27 |
| BRPI0718737A2 (pt) | 2014-03-25 |
| DK2114878T3 (da) | 2011-03-14 |
| EP2114878B1 (de) | 2010-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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