ATE481388T1 - Neuartige als anti-malaria-wirkstoffe verwendbare 4-amino-chinolinderivate - Google Patents
Neuartige als anti-malaria-wirkstoffe verwendbare 4-amino-chinolinderivateInfo
- Publication number
- ATE481388T1 ATE481388T1 AT08709064T AT08709064T ATE481388T1 AT E481388 T1 ATE481388 T1 AT E481388T1 AT 08709064 T AT08709064 T AT 08709064T AT 08709064 T AT08709064 T AT 08709064T AT E481388 T1 ATE481388 T1 AT E481388T1
- Authority
- AT
- Austria
- Prior art keywords
- malaria
- actives
- amino
- novel
- quinoline derivatives
- Prior art date
Links
- 230000000078 anti-malarial effect Effects 0.000 title abstract 2
- 150000005011 4-aminoquinolines Chemical class 0.000 title 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 abstract 1
- 241000224017 Plasmodium berghei Species 0.000 abstract 1
- 241000223960 Plasmodium falciparum Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 229960003677 chloroquine Drugs 0.000 abstract 1
- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 abstract 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 abstract 1
- 229960004022 clotrimazole Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200700263 | 2007-02-20 | ||
| US89086207P | 2007-02-21 | 2007-02-21 | |
| PCT/EP2008/051923 WO2008101891A1 (en) | 2007-02-20 | 2008-02-18 | Novel 4-amino-quinoline derivatives useful as anti-malaria drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE481388T1 true ATE481388T1 (de) | 2010-10-15 |
Family
ID=39358301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08709064T ATE481388T1 (de) | 2007-02-20 | 2008-02-18 | Neuartige als anti-malaria-wirkstoffe verwendbare 4-amino-chinolinderivate |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100093726A1 (de) |
| EP (1) | EP2121616B1 (de) |
| AT (1) | ATE481388T1 (de) |
| BR (1) | BRPI0806997A2 (de) |
| DE (1) | DE602008002563D1 (de) |
| WO (1) | WO2008101891A1 (de) |
-
2008
- 2008-02-18 EP EP08709064A patent/EP2121616B1/de not_active Not-in-force
- 2008-02-18 AT AT08709064T patent/ATE481388T1/de not_active IP Right Cessation
- 2008-02-18 DE DE602008002563T patent/DE602008002563D1/de active Active
- 2008-02-18 BR BRPI0806997-2A2A patent/BRPI0806997A2/pt not_active IP Right Cessation
- 2008-02-18 WO PCT/EP2008/051923 patent/WO2008101891A1/en not_active Ceased
- 2008-02-18 US US12/527,454 patent/US20100093726A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE602008002563D1 (de) | 2010-10-28 |
| BRPI0806997A2 (pt) | 2014-04-15 |
| US20100093726A1 (en) | 2010-04-15 |
| EP2121616B1 (de) | 2010-09-15 |
| WO2008101891A1 (en) | 2008-08-28 |
| EP2121616A1 (de) | 2009-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |