ATE48018T1 - Hybridisierungstest fuer nukleinsaeure. - Google Patents

Hybridisierungstest fuer nukleinsaeure.

Info

Publication number
ATE48018T1
ATE48018T1 AT85900525T AT85900525T ATE48018T1 AT E48018 T1 ATE48018 T1 AT E48018T1 AT 85900525 T AT85900525 T AT 85900525T AT 85900525 T AT85900525 T AT 85900525T AT E48018 T1 ATE48018 T1 AT E48018T1
Authority
AT
Austria
Prior art keywords
nucleic acid
covalent bonds
forming covalent
base sequences
hybridization test
Prior art date
Application number
AT85900525T
Other languages
English (en)
Inventor
Kenichi Ken Yabusaki
Stephen T Isaacs
Howard B Gamper Jr
Original Assignee
Hydrocarbon Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hydrocarbon Research Inc filed Critical Hydrocarbon Research Inc
Application granted granted Critical
Publication of ATE48018T1 publication Critical patent/ATE48018T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT85900525T 1983-12-12 1984-12-07 Hybridisierungstest fuer nukleinsaeure. ATE48018T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/560,430 US4599303A (en) 1983-12-12 1983-12-12 Nucleic acid hybridization assay employing probes crosslinkable to target sequences
PCT/US1984/002024 WO1985002628A1 (en) 1983-12-12 1984-12-07 Nucleic acid hybridization assay
EP85900525A EP0165313B1 (de) 1983-12-12 1984-12-07 Hybridisierungstest für nukleinsäure

Publications (1)

Publication Number Publication Date
ATE48018T1 true ATE48018T1 (de) 1989-12-15

Family

ID=24237797

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85900525T ATE48018T1 (de) 1983-12-12 1984-12-07 Hybridisierungstest fuer nukleinsaeure.

Country Status (7)

Country Link
US (1) US4599303A (de)
EP (1) EP0165313B1 (de)
JP (1) JPH0698039B2 (de)
AT (1) ATE48018T1 (de)
CA (1) CA1236410A (de)
DE (1) DE3480487D1 (de)
WO (1) WO1985002628A1 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948882A (en) * 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
US4959309A (en) * 1983-07-14 1990-09-25 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4617261A (en) * 1984-03-21 1986-10-14 Cetus Corporation Process for labeling nucleic acids and hybridization probes
US4647529A (en) * 1984-06-01 1987-03-03 Rodland Karin D Hybridization method of detecting nucleic acid sequences with probe containing thionucleotide
EP0187332B1 (de) * 1985-01-10 1989-02-01 Molecular Diagnostics, Inc. Photochemisches Verfahren zum Markieren von Nucleinsäuren zum Nachweis in Hybridisationsproben
US5026840A (en) * 1985-01-10 1991-06-25 Molecular Diagnostics, Inc. Photochemical nucleic acid-labeling reagent having a polyalklamine spacer
US4795700A (en) * 1985-01-25 1989-01-03 California Institute Of Technology Nucleic acid probes and methods of using same
US4868104A (en) * 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
CA1290664C (en) * 1986-03-05 1991-10-15 Nanibhushan Dattagupta Solution-phase single hybridization assay for detecting polynucleotide sequences
US5175270A (en) * 1986-09-10 1992-12-29 Polyprobe, Inc. Reagents for detecting and assaying nucleic acid sequences
US4908307A (en) * 1986-12-19 1990-03-13 Karin D. Rodland Hybridization method and probe for detecting nucleic acid sequences
US5034314A (en) * 1986-12-22 1991-07-23 Olin Corporation Method and kit for separating double-stranded nucleic acid from a single-stranded/double-stranded mixture of nucleic acids
US5428163A (en) * 1986-12-31 1995-06-27 Mills; Randell L. Prodrugs for selective drug delivery
AU619170B2 (en) * 1987-01-09 1992-01-23 Abbott Laboratories Diagnostic assays using nucleic acid probes
IL86164A0 (en) * 1987-04-28 1988-11-15 Tamir Biotechnology Ltd Improved dna probes
US5077400A (en) * 1987-05-04 1991-12-31 State Of Oregon . . . Oregon Health Sciences University DNA probe which reveals a hypervariable region on human chromosome 17
US5026837A (en) * 1987-05-04 1991-06-25 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University DNA probe which reveals a hypervariable region on human chromosome 16
US4826967A (en) * 1987-06-16 1989-05-02 Naxcor Psoralen-nucleoside adducts and method for their preparation
US4921805A (en) * 1987-07-29 1990-05-01 Life Technologies, Inc. Nucleic acid capture method
US5585481A (en) * 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US6031091A (en) * 1987-09-21 2000-02-29 Gen-Probe Incorporated Non-nucleotide linking reagents for nucleotide probes
US5789155A (en) 1987-10-30 1998-08-04 California Institute Of Technology Process for identifying nucleic acids and triple helices formed thereby
US5874555A (en) * 1987-10-30 1999-02-23 California Institute Of Technology Triple helices and processes for making same
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
US5256648A (en) * 1988-01-21 1993-10-26 Yale University Selective inhibition of gene expression by photoactivatable oligonucleotides
EP0353290A4 (en) * 1988-01-21 1990-09-05 Chemex Pharmaceuticals, Inc. Selective inhibition of gene expression by photoactivatable oligonucleotides
WO1989006701A1 (en) * 1988-01-25 1989-07-27 Microprobe Corporation Thiol-reactive oligonucleotide intermediates and processes for conjugation of oligonucleotides with enzymes
CA1341077C (en) * 1988-03-31 2000-08-08 Randell L. Mills Luminide and macroluminide class of pharmaceuticals
AU4181089A (en) * 1988-08-01 1990-03-05 George D. Cimino Identification of allele specific nucleic acid sequences by hybridization with crosslinkable oligonucleotide probes
US5185243A (en) * 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
USRE38416E1 (en) 1988-09-28 2004-02-03 Epoch Biosciences, Inc. Cross-linking oligonucleotides
US5849482A (en) * 1988-09-28 1998-12-15 Epoch Pharmaceuticals, Inc. Crosslinking oligonucleotides
US5824796A (en) * 1988-09-28 1998-10-20 Epoch Pharmaceuticals, Inc. Cross-linking oligonucleotides
US5082934A (en) * 1989-04-05 1992-01-21 Naxcor Coumarin derivatives for use as nucleotide crosslinking reagents
US5049489A (en) * 1989-04-17 1991-09-17 The Standard Oil Company 16S rRNA oligonucleotide probes for the identification of sulfate-reducing bacteria
WO1990014353A1 (en) * 1989-05-18 1990-11-29 Microprobe Corporation Crosslinking oligonucleotides
US5134066A (en) * 1989-08-29 1992-07-28 Monsanto Company Improved probes using nucleosides containing 3-dezauracil analogs
US5532146A (en) * 1989-10-26 1996-07-02 Hri Research, Inc. Method for rendering ligase-based amplification products unamplifiable
US6187572B1 (en) 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
US5296350A (en) * 1990-10-31 1994-03-22 The Research Foundation Of State University Of New York Ion triggered alkylation of biological targets by silyloxy aromatic agents
US5493012A (en) * 1990-10-31 1996-02-20 The Research Foundation Of State University Of New York Ion triggered alkylation of biological targets by silyloxy aromatic agents
US5831073A (en) * 1990-10-31 1998-11-03 The Research Foundation Of State University Of New York Ion triggered alkylation of biological targets by silyloxy aromatic agents
JPH06509945A (ja) * 1991-08-19 1994-11-10 マイクロプローブ・コーポレイション 酵素媒介三本鎖形成のための架橋性オリゴヌクレオチド
US6136601A (en) * 1991-08-21 2000-10-24 Epoch Pharmaceuticals, Inc. Targeted mutagenesis in living cells using modified oligonucleotides
ES2112302T3 (es) 1991-10-11 1998-04-01 Behringwerke Ag Metodo para producir un polinucleotido para uso en amplificacion con un unico cebador y oligonucleotidos que contienen fosforotioato como cebadores para la amplificacion de acidos nucleicos.
US5612199A (en) * 1991-10-11 1997-03-18 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US6652808B1 (en) * 1991-11-07 2003-11-25 Nanotronics, Inc. Methods for the electronic assembly and fabrication of devices
US6569382B1 (en) * 1991-11-07 2003-05-27 Nanogen, Inc. Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
DE4216949C2 (de) * 1992-05-22 1997-07-24 Christoph Prof Dr Dr Cremer Nichtenzymatisches Verfahren zur In-situ-Hybridisierung bei spezifischen Proben
WO1994003637A1 (en) * 1992-07-31 1994-02-17 Syntex (Usa) Inc. Method for introducing defined sequences at the 3' end of polynucleotides
US6403302B1 (en) 1992-09-17 2002-06-11 California Institute Of Technology Methods and compositions for triple helix formation
US5312527A (en) * 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5591575A (en) * 1993-04-07 1997-01-07 Amersham International Plc Subtraction hybridization employing aziridinylbenoquinone cross-linking agents
ATE210128T1 (de) * 1993-04-13 2001-12-15 Naxcor Nicht-nucleosidische cumarin-derivate als reagenzien zum crosslinking von polynucleotiden
US6294323B1 (en) 1993-04-14 2001-09-25 Behringwerke Ag Self initiating single primer amplification of nucleic acids
US5556993A (en) 1993-06-28 1996-09-17 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US6420570B1 (en) 1993-06-28 2002-07-16 Cerus Corporation Psoralen compounds
US5399719A (en) 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US5473060A (en) * 1993-07-02 1995-12-05 Lynx Therapeutics, Inc. Oligonucleotide clamps having diagnostic applications
US5650399A (en) * 1993-08-23 1997-07-22 The Research Foundation Of State University Of New York Reactive anthraquinone derivatives and conjugates thereof
ATE177842T1 (de) * 1993-09-03 1999-04-15 Behringwerke Ag Fluoreszenz-sauerstoffkanalisation-immunteste
DE19525632C2 (de) * 1995-07-14 1997-07-17 Bag Biolog Analysensystem Gmbh Sequenzspezifisches Nukleinsäurenachweisverfahren und Reagenz-System zu dessen Durchführung
EP0863998A4 (de) * 1995-11-03 2002-09-25 Naxcor Analyse von polymorphismen bei doppelsträngiger konformation
US6706473B1 (en) 1996-12-06 2004-03-16 Nanogen, Inc. Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
AU747842B2 (en) * 1997-11-20 2002-05-23 Cerus Corporation New psoralens for pathogen inactivation
ATE340870T1 (de) * 1998-04-03 2006-10-15 Compound Therapeutics Inc Adressierbare protein arrays
US6015676A (en) * 1998-07-31 2000-01-18 Epiclone Inc. Method for knocking out gene transcripts by covalently binding of an anti-sense probe
JP2002524091A (ja) * 1998-08-21 2002-08-06 ナックスコー・インコーポレイテッド 架橋可能な固定化核酸を用いるアッセイ
US20030124547A1 (en) * 1998-09-04 2003-07-03 Risa Peoples Hybridization assays for gene dosage analysis
US6303799B1 (en) 1998-11-10 2001-10-16 Naxcor Polynucleotide crosslinking agents
EP1006199A1 (de) * 1998-12-03 2000-06-07 Kreatech Biotechnology B.V. Verfahren zur Herstellung von Verknüpfungen an ausgewählten Positionen von Nukleinsäuresträngen und deren Verwendung
AU2877000A (en) * 1999-02-10 2000-08-29 University Of Maryland Photo-induced nucleic acid hybridization
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6573048B1 (en) * 2000-04-18 2003-06-03 Naxcor Degradable nucleic acid probes and nucleic acid detection methods
US6962781B1 (en) * 2000-05-19 2005-11-08 Proteonova, Inc. In vitro evolution of nucleic acids and encoded polypeptide
US7410761B2 (en) * 2000-05-19 2008-08-12 Proteonova, Inc. System for rapid identification and selection of nucleic acids and polypeptides, and method thereof
US20040229271A1 (en) 2000-05-19 2004-11-18 Williams Richard B. Compositions and methods for the identification and selection of nucleic acids and polypeptides
CA2409305C (en) * 2000-05-19 2011-01-11 Richard B. Williams In vitro evolution of nucleic acids and encoded polypeptide
WO2001095944A2 (en) * 2000-06-12 2001-12-20 Mills Randell L Photocleavable prodrugs for selective drug delivery
US6380377B1 (en) * 2000-07-14 2002-04-30 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
DE10201463B4 (de) 2002-01-16 2005-07-21 Clondiag Chip Technologies Gmbh Reaktionsgefäß zur Durchführung von Array-Verfahren
DK1487978T3 (da) * 2002-03-15 2009-03-23 Nuevolution As Forbedret fremgangsmåde til syntese af templatemolekyler
DE10232139A1 (de) * 2002-07-04 2004-01-22 Technische Universität Dresden Mit Nukleinsäuren und Nukleinsäurederivaten beschichteter metallischer Gegenstand, Verfahren zu dessen Herstellung und dessen Verwendung
US20040265870A1 (en) * 2003-04-09 2004-12-30 Invitrogen Corporation Methods of synthesizing and labeling nucleic acid molecules
US20050080260A1 (en) * 2003-04-22 2005-04-14 Mills Randell L. Preparation of prodrugs for selective drug delivery
JPWO2005103695A1 (ja) * 2004-04-23 2008-03-13 松下電器産業株式会社 遺伝子検出方法及び遺伝子検出装置
US7828954B2 (en) * 2004-09-21 2010-11-09 Gamida For Life B.V. Electrode based patterning of thin film self-assembled nanoparticles
CA2598670A1 (en) * 2005-02-22 2006-08-31 Arizona Board Of Regents For And On Behalf Of Arizona State University Dna crosslinking for primer extension assays
AU2008216303A1 (en) 2007-02-12 2008-08-21 Proteonova, Inc. Generation of library of soluble random polypeptides linked to mRNA
JP5744743B2 (ja) * 2008-11-17 2015-07-08 ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. 共有結合形成反応ペアを用いた標的分子の粒子ベースの検出における方法および組成物
US9150910B2 (en) * 2008-11-17 2015-10-06 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using linking molecules
WO2012108864A1 (en) 2011-02-08 2012-08-16 Illumina, Inc. Selective enrichment of nucleic acids
US9447455B2 (en) 2011-02-16 2016-09-20 Headway Technologies, Inc. Methods and compositions for the target-localized anchoring of detectable label
WO2017003950A2 (en) * 2015-06-27 2017-01-05 Children's Medical Center Corporation Compositions and methods for analyte detection using nanoswitches

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US314167A (en) * 1885-03-17 curtiss
US3798131A (en) * 1972-04-24 1974-03-19 Pasadena Foundation For Medica Assay for polymeric dna as a method for detecting malignancy
US4169204A (en) * 1976-10-20 1979-09-25 Regents Of The University Of California Psoralens
US4347447A (en) * 1981-04-16 1982-08-31 Mostek Corporation Current limiting MOS transistor driver circuit
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method

Also Published As

Publication number Publication date
EP0165313B1 (de) 1989-11-15
EP0165313A4 (de) 1986-05-16
WO1985002628A1 (en) 1985-06-20
JPH0698039B2 (ja) 1994-12-07
US4599303A (en) 1986-07-08
CA1236410A (en) 1988-05-10
EP0165313A1 (de) 1985-12-27
JPS61500688A (ja) 1986-04-10
DE3480487D1 (en) 1989-12-21

Similar Documents

Publication Publication Date Title
ATE48018T1 (de) Hybridisierungstest fuer nukleinsaeure.
ATE54028T1 (de) Hybridisierungstest fuer nukleinsaeure mittels anwendung von nachweisbaren antihybridantik¯rpern.
DE3785865D1 (de) Schnellverfahren zum nachweis von nukleinsaeure-sequenzen in einer probe mittels probemarkierung.
NO900582L (no) Maalemetode.
EP0139489A3 (de) Sandwichhybridisierungsverfahren zum Nachweis von Nukleinsäuren
DE3677026D1 (de) Dualhybridisierungstest in loesung-phase zur bestimmung von polynucleotidsequenzen.
ES2083955T3 (es) Determinacion de polinucleotidos con sitios de escision seleccionables.
ES2074051T3 (es) Ensayo de proteccion homogeneo.
ES8507181A1 (es) Un metodo para la determinacion de un polinucleotido
ATE82773T1 (de) Diagnostischer test unter verwendung von nucleinsaeure-sonden.
ES8607560A1 (es) Un metodo para detectar una secuencia nucleotidica deteminada en una muestra
ES8607557A1 (es) Un metodo para detectar una secuencia polinuscleotidica determinada en un medio a ensayar
KR870009032A (ko) 핵산을 함유하는 시료중의 미생물의 검출
ATE171277T1 (de) Enzymtest und testsatz zur messung zellulärer aktivierung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee