ATE476419T1 - Isochinolinon-kaliumkanalinhibitoren - Google Patents
Isochinolinon-kaliumkanalinhibitorenInfo
- Publication number
- ATE476419T1 ATE476419T1 AT04784368T AT04784368T ATE476419T1 AT E476419 T1 ATE476419 T1 AT E476419T1 AT 04784368 T AT04784368 T AT 04784368T AT 04784368 T AT04784368 T AT 04784368T AT E476419 T1 ATE476419 T1 AT E476419T1
- Authority
- AT
- Austria
- Prior art keywords
- potassium channel
- channel inhibitors
- isoquinolinone
- isoquinolinone potassium
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50521503P | 2003-09-23 | 2003-09-23 | |
| PCT/US2004/030484 WO2005030726A1 (en) | 2003-09-23 | 2004-09-17 | Isoquinolinone potassium channel inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE476419T1 true ATE476419T1 (de) | 2010-08-15 |
Family
ID=34392991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04784368T ATE476419T1 (de) | 2003-09-23 | 2004-09-17 | Isochinolinon-kaliumkanalinhibitoren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7741322B2 (https=) |
| EP (1) | EP1667976B1 (https=) |
| JP (1) | JP4717815B2 (https=) |
| CN (1) | CN1856472A (https=) |
| AT (1) | ATE476419T1 (https=) |
| AU (1) | AU2004276238B2 (https=) |
| CA (1) | CA2539729C (https=) |
| DE (1) | DE602004028493D1 (https=) |
| WO (1) | WO2005030726A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4719151B2 (ja) * | 2003-09-23 | 2011-07-06 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリノンカリウムチャネル阻害剤 |
| WO2005030791A2 (en) * | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
| CN1856473A (zh) * | 2003-09-23 | 2006-11-01 | 默克公司 | 异喹啉酮钾通道抑制剂 |
| EP1667981A4 (en) * | 2003-09-23 | 2008-08-13 | Merck & Co Inc | ISOCHINOLINE AS KALIUM CHANNEL INHIBITORS |
| US7879839B2 (en) | 2004-07-29 | 2011-02-01 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
| US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
| EP1922311A2 (en) | 2005-09-09 | 2008-05-21 | Brystol-Myers Squibb Company | Acyclic ikur inhibitors |
| EP1996198A1 (en) * | 2006-03-17 | 2008-12-03 | Kalypsys, Inc. | Alkylamine-substituted bicyclic aryl compounds useful as modulators of ppar |
| DE102006019589A1 (de) * | 2006-04-27 | 2007-10-31 | Sanofi-Aventis Deutschland Gmbh | Inhibitoren des TASK-1 und Task-3 Ionenkanals |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| ES2475193T3 (es) | 2007-01-22 | 2014-07-10 | Gtx, Inc. | Agentes de unión al receptor nuclear |
| EP3668841A1 (en) * | 2017-08-14 | 2020-06-24 | Acesion Pharma ApS | Substituted benzimidazoles as potassium channel inhibitors |
| CN110670090B (zh) * | 2019-11-13 | 2021-06-29 | 广西师范大学 | 一种基于电化学合成异喹啉酮类化合物的方法 |
| KR20240149429A (ko) * | 2022-02-16 | 2024-10-14 | 듀크 스트리트 바이오 리미티드 | 약학적 화합물 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3594380A (en) * | 1969-02-18 | 1971-07-20 | American Home Prod | Isoquinolin-1(2h)-ones |
| EP0585913B1 (en) | 1992-09-04 | 1997-12-29 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
| EP0634402A1 (en) * | 1993-07-14 | 1995-01-18 | Takeda Chemical Industries, Ltd. | Isochinolinone derivatives, their production and use |
| US5387685A (en) | 1993-07-16 | 1995-02-07 | American Cyanamid Co | MDR reversal agents |
| EP1322619B1 (en) | 2000-09-20 | 2008-01-23 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
| JPWO2002094790A1 (ja) * | 2001-05-23 | 2004-09-09 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
| AU2003211931A1 (en) * | 2002-02-13 | 2003-09-04 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
| JP4719151B2 (ja) * | 2003-09-23 | 2011-07-06 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリノンカリウムチャネル阻害剤 |
| WO2005030791A2 (en) * | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
| CN1856473A (zh) * | 2003-09-23 | 2006-11-01 | 默克公司 | 异喹啉酮钾通道抑制剂 |
| EP1667981A4 (en) * | 2003-09-23 | 2008-08-13 | Merck & Co Inc | ISOCHINOLINE AS KALIUM CHANNEL INHIBITORS |
-
2004
- 2004-09-17 WO PCT/US2004/030484 patent/WO2005030726A1/en not_active Ceased
- 2004-09-17 CN CNA2004800273770A patent/CN1856472A/zh active Pending
- 2004-09-17 AT AT04784368T patent/ATE476419T1/de not_active IP Right Cessation
- 2004-09-17 CA CA2539729A patent/CA2539729C/en not_active Expired - Fee Related
- 2004-09-17 DE DE602004028493T patent/DE602004028493D1/de not_active Expired - Lifetime
- 2004-09-17 US US10/571,858 patent/US7741322B2/en not_active Expired - Fee Related
- 2004-09-17 EP EP04784368A patent/EP1667976B1/en not_active Expired - Lifetime
- 2004-09-17 JP JP2006527053A patent/JP4717815B2/ja not_active Expired - Fee Related
- 2004-09-17 AU AU2004276238A patent/AU2004276238B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007506679A (ja) | 2007-03-22 |
| DE602004028493D1 (de) | 2010-09-16 |
| CN1856472A (zh) | 2006-11-01 |
| AU2004276238B2 (en) | 2010-10-28 |
| CA2539729C (en) | 2010-09-07 |
| EP1667976A4 (en) | 2008-02-13 |
| JP4717815B2 (ja) | 2011-07-06 |
| AU2004276238A1 (en) | 2005-04-07 |
| US7741322B2 (en) | 2010-06-22 |
| WO2005030726A1 (en) | 2005-04-07 |
| EP1667976A1 (en) | 2006-06-14 |
| US20060281743A1 (en) | 2006-12-14 |
| EP1667976B1 (en) | 2010-08-04 |
| CA2539729A1 (en) | 2005-04-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2005030791A3 (en) | Isoquinolinone potassium channel inhibitors | |
| NO20082298L (no) | Kaliumkanalinhibitorer | |
| WO2005046578A3 (en) | Isoquinolinone potassium channel inhibitors | |
| WO2005030129A3 (en) | Quinoline potassium channel inhibitors | |
| WO2005030130A3 (en) | Isoquinoline potassium channel inhibitors | |
| WO2006015159A3 (en) | Potassium channel inhibitors | |
| IS7721A (is) | Píperidín-pýrídasón og þalasón sem PDE4 hemlar | |
| DE69940480D1 (de) | Carbocyclische kaliumkanalhemmer | |
| ATE290382T1 (de) | Heterozyklische kalium-kanal inhibitoren | |
| BRPI0411897A (pt) | pirroldihidroisoquinolinas como inibidores de pde10 | |
| EA200701396A1 (ru) | Триазолофталазины в качестве ингибиторов pde-2 | |
| ATE549024T1 (de) | Chinazolin-kaliumkanalhemmer | |
| ATE476419T1 (de) | Isochinolinon-kaliumkanalinhibitoren | |
| HRP20080057T3 (en) | 9,10-alpha,alpha-oh-taxane analogs and methods for production thereof | |
| WO2005030792A3 (en) | Quinoline potassium channel inhibitors | |
| DE60329326D1 (de) | Tace inhibitoren | |
| WO2007050348A3 (en) | Potassium channel inhibitors | |
| ATE419242T1 (de) | Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren | |
| ATE372330T1 (de) | N-sulfonylurea-apoptosis-förderer | |
| WO2006014877A3 (en) | Potassium channel inhibitors | |
| WO2007089743A3 (en) | Potassium channel inhibitors | |
| TW200815363A (en) | KV1.5 potassium channel inhibitors | |
| TW200607493A (en) | Potassium channel inhibitors | |
| ATE493390T1 (de) | 2,3-diaryl-pyrazolidine derivate als neurotensin abbauende enzyme-inhibitoren | |
| WO2007015775A3 (en) | Potassium channel inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |