ATE474055T1 - Verfahren zur herstellung thy-a defiziente vibrio cholerae stämme, solche stämme und deren verwendung - Google Patents

Verfahren zur herstellung thy-a defiziente vibrio cholerae stämme, solche stämme und deren verwendung

Info

Publication number
ATE474055T1
ATE474055T1 AT99927745T AT99927745T ATE474055T1 AT E474055 T1 ATE474055 T1 AT E474055T1 AT 99927745 T AT99927745 T AT 99927745T AT 99927745 T AT99927745 T AT 99927745T AT E474055 T1 ATE474055 T1 AT E474055T1
Authority
AT
Austria
Prior art keywords
thy
strain
vibrio cholerae
sup
strains
Prior art date
Application number
AT99927745T
Other languages
English (en)
Inventor
Nils Carlin
Michael Lebens
Original Assignee
Crucell Sweden Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Sweden Ab filed Critical Crucell Sweden Ab
Application granted granted Critical
Publication of ATE474055T1 publication Critical patent/ATE474055T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245Escherichia (G)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/43559Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from trematodes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1003Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007Methyltransferases (general) (2.1.1.)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
AT99927745T 1998-05-26 1999-05-21 Verfahren zur herstellung thy-a defiziente vibrio cholerae stämme, solche stämme und deren verwendung ATE474055T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9801852A SE9801852D0 (sv) 1998-05-26 1998-05-26 Method of producing thy A-strains of Vibro cholerae, suck strains and their use
PCT/EP1999/003509 WO1999061634A1 (en) 1998-05-26 1999-05-21 Method of producing thy a-strains of vibrio cholerae, such strains and their use

Publications (1)

Publication Number Publication Date
ATE474055T1 true ATE474055T1 (de) 2010-07-15

Family

ID=20411459

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99927745T ATE474055T1 (de) 1998-05-26 1999-05-21 Verfahren zur herstellung thy-a defiziente vibrio cholerae stämme, solche stämme und deren verwendung

Country Status (18)

Country Link
US (1) US7261899B1 (de)
EP (1) EP1080211B1 (de)
AT (1) ATE474055T1 (de)
AU (1) AU4499999A (de)
BR (1) BR9910703B1 (de)
CA (1) CA2329255C (de)
CZ (1) CZ301662B6 (de)
DE (1) DE69942579D1 (de)
DK (1) DK1080211T3 (de)
EE (1) EE05520B1 (de)
HK (1) HK1037206A1 (de)
HU (1) HUP0102310A3 (de)
IS (1) IS2904B (de)
NO (1) NO327856B1 (de)
PL (1) PL197450B1 (de)
RU (1) RU2265657C2 (de)
SE (1) SE9801852D0 (de)
WO (1) WO1999061634A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU22661A1 (es) * 1997-12-30 2001-04-27 Cnic Ct Nac Investigaciones Nuevos candidatos vacunales de vibrio cholerae y método de obtención
SE9801852D0 (sv) * 1998-05-26 1998-05-26 Sbl Vaccin Ab Method of producing thy A-strains of Vibro cholerae, suck strains and their use
GB0121998D0 (en) 2001-09-11 2001-10-31 Acambis Res Ltd Attenuated bacteria useful in vaccines
GB0325494D0 (en) * 2003-10-31 2003-12-03 Sbl Vaccin Ab Expression system
JP2010088301A (ja) * 2007-02-01 2010-04-22 Ajinomoto Co Inc L−アミノ酸の製造法
DK3503915T5 (da) * 2016-08-26 2024-09-02 Telesis Bio Inc Genetisk modificerede Vibro natriegen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470729A (en) * 1983-03-04 1995-11-28 University Of Maryland At Baltimore Method of isolating restriction fragment deletions in Vibrio cholerae, and products thereof
GB2177097A (en) 1985-06-18 1987-01-14 Genencor Inc Stable maintenance of nucleic acid in recombinant cells
EP0251579A3 (de) * 1986-06-24 1989-03-22 Enterovax Research Pty. Ltd. Markiersystem ohne Antibiotika
US5198343A (en) 1986-08-05 1993-03-30 Transgene, S.A. Method for expressing a heterologous protein in a dapD- mutant of E. coli and the strain obtained
IE892131A1 (en) * 1989-06-30 1991-01-02 Univ Cork Marker genes for genetic manipulation
ATE359370T1 (de) 1993-02-22 2007-05-15 Gen Hospital Corp Heterologe antigene in stämmen zur impfung mit lebendzellen
US5434065A (en) * 1993-05-06 1995-07-18 President And Fellows Of Harvard College In vivo selection of microbial virulence genes
WO1996012801A1 (en) * 1994-10-24 1996-05-02 The Texas A & M University System Oral immunization with transgenic plants
US6251866B1 (en) * 1997-08-05 2001-06-26 Watson Laboratories, Inc. Conjugates targeted to the interleukin-2 receptor
CU22661A1 (es) * 1997-12-30 2001-04-27 Cnic Ct Nac Investigaciones Nuevos candidatos vacunales de vibrio cholerae y método de obtención
SE9801852D0 (sv) * 1998-05-26 1998-05-26 Sbl Vaccin Ab Method of producing thy A-strains of Vibro cholerae, suck strains and their use

Also Published As

Publication number Publication date
HUP0102310A2 (hu) 2001-10-28
DK1080211T3 (da) 2010-10-18
EE200000686A (et) 2002-04-15
IS5724A (is) 2000-11-23
EP1080211A1 (de) 2001-03-07
US7261899B1 (en) 2007-08-28
HK1037206A1 (en) 2002-02-01
CA2329255A1 (en) 1999-12-02
CA2329255C (en) 2009-03-10
CZ301662B6 (cs) 2010-05-19
DE69942579D1 (de) 2010-08-26
PL197450B1 (pl) 2008-03-31
CZ20004354A3 (en) 2001-05-16
WO1999061634A9 (en) 2001-12-13
IS2904B (is) 2014-10-15
EE05520B1 (et) 2012-02-15
EP1080211B1 (de) 2010-07-14
NO20005950D0 (no) 2000-11-24
RU2265657C2 (ru) 2005-12-10
HUP0102310A3 (en) 2003-10-28
NO20005950L (no) 2001-01-25
SE9801852D0 (sv) 1998-05-26
AU4499999A (en) 1999-12-13
WO1999061634A1 (en) 1999-12-02
BR9910703B1 (pt) 2014-10-29
PL344483A1 (en) 2001-11-05
NO327856B1 (no) 2009-10-05
BR9910703A (pt) 2001-01-30

Similar Documents

Publication Publication Date Title
US5122458A (en) Use of a bgh gdna polyadenylation signal in expression of non-bgh polypeptides in higher eukaryotic cells
ATE77104T1 (de) Menge und verfahren zur herstellung rekombinierter erzeugnisse in grosser ausbeute.
ATE245701T1 (de) Modifizierte pilzzellen und methode zur herstelllung rekombinanter produkte
DE3586304D1 (de) Verfahren zur herstellung von proteinen und transformierten zellen und dna-konstruktionen zur korrektur von mankos und wirtszellen sowie deren herstellung und verwendung.
EP0963435A4 (de) Verfahren zur herstellung von proteinen
FR2677652A1 (fr) Procede de preparation d'une proteine d'interet dans le lait d'un animal transgenique, produit obtenu et cellule eucaryote utilisee.
ATE123065T1 (de) Proteine und deren herstellung.
WO1999020766A3 (en) NOVEL MODIFIED NUCLEIC ACID SEQUENCES AND METHODS FOR INCREASING mRNA LEVELS AND PROTEIN EXPRESSION IN CELL SYSTEMS
ATE474055T1 (de) Verfahren zur herstellung thy-a defiziente vibrio cholerae stämme, solche stämme und deren verwendung
WO2001044276A3 (en) Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols carotenoids and aromatic amino acids
WO2001075132A3 (en) Method for producing authentic cytokines in plants
ATE480624T1 (de) Yapsin-mangelmutantenstamm von hansenula polymorpha sowie verfahren zur herstellung rekombinanter proteine damit
EP0114695B1 (de) Für eine Signal-Aminosäuresequenz kodierende DNS und diese Sequenz enthaltende Vektoren
EP0672150B1 (de) Veränderte kluveromyces hefe ihre herstellung und verwendung
ATE346927T1 (de) Gene, welche für luziferin regenerierende proteine kodieren, rekombinante dna und verfahren zur herstellung eines luziferin regenerierenden proteins
RU2000132731A (ru) Способ получения thy a-штаммов vibro cholerae, такие штаммы и их применение
KR100428998B1 (ko) 모체 단백질과는 크기와 서열이 다른 단백질의 변이집단을생산하는 방법
IE850606L (en) Prochymosin vector for expression in e. coli.
DK1633873T3 (da) Bakterier med forøgede niveauer af proteinsekretion, nukleotidsekvenser kodende for et SecA-protein med forøgede niveauer af proteinsekretion og fremgangsmåde til fremstilling af proteiner
ATE339499T1 (de) Gene welche für proteine, die befähigt sind luziferin zu regenerieren, kodieren, rekombinante dna und verfahren zur herstellung von proteinen, die befähigt sind luziferin zu regenerieren
ATE122097T1 (de) Expressionsvektor und verfahren zur regulierbaren herstellung von proteinen in eukaryonten.
JPH08228787A (ja) 牛成長ホルモンの大量生産方法
FR2678636A1 (fr) Procede de production de proteines recombinantes et cellules hote utilisees.
TH2022EX (th) มิวแตนท์ของ วิบริโอ คอเลอรี ที่ไม่มีพิษ
DK0959130T3 (da) Kloning og udtrykkelse af nyt glucoamylasegen fra Endomyces fibuliger

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties