ATE471316T1 - Diastereoselektives syntheseverfahren mit 6-brom- 4-(3-chlorphenyl)-2-methoxychinolin - Google Patents
Diastereoselektives syntheseverfahren mit 6-brom- 4-(3-chlorphenyl)-2-methoxychinolinInfo
- Publication number
- ATE471316T1 ATE471316T1 AT05736074T AT05736074T ATE471316T1 AT E471316 T1 ATE471316 T1 AT E471316T1 AT 05736074 T AT05736074 T AT 05736074T AT 05736074 T AT05736074 T AT 05736074T AT E471316 T1 ATE471316 T1 AT E471316T1
- Authority
- AT
- Austria
- Prior art keywords
- methoxyquinoline
- chlorphenyl
- bromine
- synthesis method
- diastereoselective synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04076321 | 2004-05-03 | ||
| PCT/EP2005/051932 WO2005105783A1 (en) | 2004-05-03 | 2005-04-28 | Diastereoselective synthesis process with 6-bromo-4-(3-chlorophenyl)-2-methoxy-quinoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE471316T1 true ATE471316T1 (de) | 2010-07-15 |
Family
ID=34965002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05736074T ATE471316T1 (de) | 2004-05-03 | 2005-04-28 | Diastereoselektives syntheseverfahren mit 6-brom- 4-(3-chlorphenyl)-2-methoxychinolin |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7572916B2 (de) |
| EP (1) | EP1756085B1 (de) |
| JP (1) | JP4917022B2 (de) |
| CN (1) | CN100567291C (de) |
| AT (1) | ATE471316T1 (de) |
| AU (1) | AU2005238222B2 (de) |
| CA (1) | CA2563806C (de) |
| DE (1) | DE602005021878D1 (de) |
| ES (1) | ES2346986T3 (de) |
| HK (1) | HK1101398A1 (de) |
| WO (1) | WO2005105783A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009313927A1 (en) | 2008-11-13 | 2010-05-20 | Astrazeneca Ab | Azaquinolinone derivatives and uses thereof |
| EP3995589A1 (de) | 2015-08-17 | 2022-05-11 | Kura Oncology, Inc. | Verfahren zur behandlung von krebspatienten mit farnesyl-transferase-inhibitoren |
| CA3042747A1 (en) | 2016-11-03 | 2018-05-11 | Kura Oncology, Inc. | Methods of treating cancer patients with farnesyltransferase inhibitors |
| WO2019222565A1 (en) * | 2018-05-18 | 2019-11-21 | Kura Oncology, Inc. | Synthesis of tipifarnib |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69620445T2 (de) | 1995-12-08 | 2002-12-12 | Janssen Pharmaceutica N.V., Beerse | (imidazol-5-yl)methyl-2-chinolinoderivate als farnesyl protein transferase inhibitoren |
| WO2001051127A1 (en) | 2000-01-12 | 2001-07-19 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| AU2001229320A1 (en) * | 2000-01-12 | 2001-07-24 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
| HN2000000266A (es) | 2000-01-21 | 2001-05-21 | Pfizer Prod Inc | Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto. |
| AU2001290588A1 (en) | 2000-09-05 | 2002-03-22 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
| EP1373255B1 (de) * | 2001-03-12 | 2005-01-26 | Janssen Pharmaceutica N.V. | Verfahren zur herstellung von imidazolverbindungen |
| AU2002254375A1 (en) | 2001-03-30 | 2002-10-15 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
| AU2003274759A1 (en) * | 2002-10-28 | 2004-05-13 | Chugai Seiyaku Kabushiki Kaisha | Benzofuran compounds having antitumor activity |
| WO2004076446A1 (ja) * | 2003-02-27 | 2004-09-10 | Chugai Seiyaku Kabushiki Kaisha | ベンゾチオフェン誘導体 |
| CA2563805C (en) * | 2004-05-03 | 2012-11-13 | Janssen Pharmaceutica N.V. | Diastereoselective addition of lithiated n-methylimidazole on sulfinimines |
-
2005
- 2005-04-28 CN CNB2005800130748A patent/CN100567291C/zh active Active
- 2005-04-28 AU AU2005238222A patent/AU2005238222B2/en active Active
- 2005-04-28 JP JP2007512169A patent/JP4917022B2/ja active Active
- 2005-04-28 DE DE602005021878T patent/DE602005021878D1/de active Active
- 2005-04-28 WO PCT/EP2005/051932 patent/WO2005105783A1/en active Application Filing
- 2005-04-28 EP EP05736074A patent/EP1756085B1/de active Active
- 2005-04-28 ES ES05736074T patent/ES2346986T3/es active Active
- 2005-04-28 CA CA2563806A patent/CA2563806C/en active Active
- 2005-04-28 US US11/568,420 patent/US7572916B2/en active Active
- 2005-04-28 AT AT05736074T patent/ATE471316T1/de not_active IP Right Cessation
-
2007
- 2007-08-27 HK HK07109303.6A patent/HK1101398A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2563806A1 (en) | 2005-11-10 |
| AU2005238222A1 (en) | 2005-11-10 |
| CN1946710A (zh) | 2007-04-11 |
| AU2005238222B2 (en) | 2010-10-28 |
| HK1101398A1 (en) | 2007-10-18 |
| DE602005021878D1 (de) | 2010-07-29 |
| EP1756085A1 (de) | 2007-02-28 |
| JP4917022B2 (ja) | 2012-04-18 |
| US7572916B2 (en) | 2009-08-11 |
| CN100567291C (zh) | 2009-12-09 |
| CA2563806C (en) | 2012-11-20 |
| ES2346986T3 (es) | 2010-10-22 |
| WO2005105783A1 (en) | 2005-11-10 |
| JP2007536334A (ja) | 2007-12-13 |
| US20070293680A1 (en) | 2007-12-20 |
| EP1756085B1 (de) | 2010-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |