ATE458498T1 - Zellwachstumshemmer mit anti-pept-antikörper - Google Patents

Zellwachstumshemmer mit anti-pept-antikörper

Info

Publication number
ATE458498T1
ATE458498T1 AT02788719T AT02788719T ATE458498T1 AT E458498 T1 ATE458498 T1 AT E458498T1 AT 02788719 T AT02788719 T AT 02788719T AT 02788719 T AT02788719 T AT 02788719T AT E458498 T1 ATE458498 T1 AT E458498T1
Authority
AT
Austria
Prior art keywords
pept
cell growth
antibodies
growth inhibitors
cytotoxic activity
Prior art date
Application number
AT02788719T
Other languages
English (en)
Inventor
Tatsuhiko Kodama
Takao Hamakubo
Ryoichi Saitoh
Iwao Ohizumi
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE458498T1 publication Critical patent/ATE458498T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02788719T 2001-12-04 2002-12-04 Zellwachstumshemmer mit anti-pept-antikörper ATE458498T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001369608 2001-12-04
JP2002164834 2002-06-05
PCT/JP2002/012708 WO2003047621A1 (fr) 2001-12-04 2002-12-04 Inhibiteur de la proliferation cellulaire contenant un anticorps dirige contre pept

Publications (1)

Publication Number Publication Date
ATE458498T1 true ATE458498T1 (de) 2010-03-15

Family

ID=26624860

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02788719T ATE458498T1 (de) 2001-12-04 2002-12-04 Zellwachstumshemmer mit anti-pept-antikörper

Country Status (7)

Country Link
US (1) US7666998B2 (de)
EP (1) EP1462113B1 (de)
JP (2) JPWO2003047621A1 (de)
AT (1) ATE458498T1 (de)
AU (1) AU2002354374A1 (de)
DE (1) DE60235499D1 (de)
WO (1) WO2003047621A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2003033024A1 (ja) * 2001-10-16 2006-07-06 中外製薬株式会社 細胞増殖抑制剤
JPWO2003047621A1 (ja) 2001-12-04 2005-04-14 中外製薬株式会社 抗ＰｅｐＴ抗体を含有する細胞増殖抑制剤
WO2003083116A1 (fr) 2002-03-29 2003-10-09 Chugai Seiyaku Kabushiki Kaisha Procede de criblage d'inhibiteurs de transporteurs
AU2003242024A1 (en) 2002-06-05 2003-12-22 Chugai Seiyaku Kabushiki Kaisha Method of constructing antibody
US7731960B2 (en) 2003-03-28 2010-06-08 Chugai Seiyaku Kabushiki Kaisha Antibodies that inhibit transport activity of peptide transporters
JP4846569B2 (ja) 2004-03-31 2011-12-28 中外製薬株式会社 抗体作製用非ヒト動物およびこれを用いた抗体作製方法およびシステム
WO2016022821A1 (en) * 2014-08-06 2016-02-11 Georgia State University Research Foundation, Inc. Compositions and methods for treating colorectal cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL108499A (en) 1993-02-04 2000-02-29 Lilly Co Eli Mammalian influx peptide transporter
US5500346A (en) * 1993-06-29 1996-03-19 Eli Lilly And Company Monoclonal antibodies to human influx peptide transporter
US5849525A (en) * 1994-03-09 1998-12-15 Brigham And Women's Hospital, Inc. Compositions corresponding to a proton-coupled peptide transporter and methods of making and using same
JPH08134100A (ja) 1994-11-09 1996-05-28 Unitika Ltd 糖鎖特異的抗体の製造方法
WO1997019919A1 (fr) 1995-11-30 1997-06-05 C & C Research Laboratories Derives de sulfamides
FR2761994B1 (fr) * 1997-04-11 1999-06-18 Centre Nat Rech Scient Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
JPH11172A (ja) 1997-06-11 1999-01-06 Snow Brand Milk Prod Co Ltd ペプチド輸送タンパク質遺伝子を含むｄｎａ、ベクター及び微生物
US6867017B1 (en) * 1998-10-23 2005-03-15 The United States Of America As Represented By The Department Of Health And Human Services ATP-binding transporter (ABC7) and methods for detection of anemia and ataxia
CA2350207C (en) 1998-11-10 2011-02-08 University Of Rochester T cells specific for target antigens and methods and vaccines based thereon
JP4552056B2 (ja) 1999-11-15 2010-09-29 独立行政法人科学技術振興機構 後天的免疫寛容の獲得方法
JP2001197846A (ja) 2000-01-18 2001-07-24 Ys New Technology Kenkyusho:Kk 免疫寛容動物の作製方法
JPWO2003033024A1 (ja) * 2001-10-16 2006-07-06 中外製薬株式会社 細胞増殖抑制剤
JPWO2003047621A1 (ja) 2001-12-04 2005-04-14 中外製薬株式会社 抗ＰｅｐＴ抗体を含有する細胞増殖抑制剤
WO2003083116A1 (fr) 2002-03-29 2003-10-09 Chugai Seiyaku Kabushiki Kaisha Procede de criblage d'inhibiteurs de transporteurs
AU2003242024A1 (en) * 2002-06-05 2003-12-22 Chugai Seiyaku Kabushiki Kaisha Method of constructing antibody
US7731960B2 (en) * 2003-03-28 2010-06-08 Chugai Seiyaku Kabushiki Kaisha Antibodies that inhibit transport activity of peptide transporters
JP4846569B2 (ja) 2004-03-31 2011-12-28 中外製薬株式会社 抗体作製用非ヒト動物およびこれを用いた抗体作製方法およびシステム

Also Published As

Publication number Publication date
US20050281825A1 (en) 2005-12-22
DE60235499D1 (de) 2010-04-08
JPWO2003047621A1 (ja) 2005-04-14
EP1462113A4 (de) 2004-12-29
EP1462113A1 (de) 2004-09-29
WO2003047621A1 (fr) 2003-06-12
JP2010013471A (ja) 2010-01-21
US7666998B2 (en) 2010-02-23
AU2002354374A1 (en) 2003-06-17
EP1462113B1 (de) 2010-02-24

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