ATE453409T1 - Entzündungshemmende fettalkohole und fettsäureester als antigenträger - Google Patents
Entzündungshemmende fettalkohole und fettsäureester als antigenträgerInfo
- Publication number
- ATE453409T1 ATE453409T1 AT02761953T AT02761953T ATE453409T1 AT E453409 T1 ATE453409 T1 AT E453409T1 AT 02761953 T AT02761953 T AT 02761953T AT 02761953 T AT02761953 T AT 02761953T AT E453409 T1 ATE453409 T1 AT E453409T1
- Authority
- AT
- Austria
- Prior art keywords
- fatty acid
- antigen
- inflammatory
- acid esters
- fat alcohols
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 4
- 102000036639 antigens Human genes 0.000 title abstract 4
- 108091007433 antigens Proteins 0.000 title abstract 4
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 title abstract 2
- 229930195729 fatty acid Chemical class 0.000 title abstract 2
- 239000000194 fatty acid Chemical class 0.000 title abstract 2
- 150000001298 alcohols Chemical class 0.000 title 1
- 239000000969 carrier Substances 0.000 title 1
- 150000004665 fatty acids Chemical class 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 230000002584 immunomodulator Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000008506 pathogenesis Effects 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL14253601A IL142536A0 (en) | 2001-04-11 | 2001-04-11 | Carriers for therapeutic preparations for treatment of t-cell mediated diseases |
| PCT/IL2002/000295 WO2002083058A2 (en) | 2001-04-11 | 2002-04-11 | Anti-inflammatory fatty alcohols and fatty acid esters useful as antigen carriers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453409T1 true ATE453409T1 (de) | 2010-01-15 |
Family
ID=11075313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02761953T ATE453409T1 (de) | 2001-04-11 | 2002-04-11 | Entzündungshemmende fettalkohole und fettsäureester als antigenträger |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20040247604A1 (de) |
| EP (1) | EP1408951B1 (de) |
| JP (1) | JP2004526757A (de) |
| KR (1) | KR20030096311A (de) |
| CN (1) | CN1327898C (de) |
| AT (1) | ATE453409T1 (de) |
| AU (1) | AU2002307767B2 (de) |
| CA (1) | CA2442943A1 (de) |
| DE (1) | DE60234927D1 (de) |
| HU (1) | HUP0303796A3 (de) |
| IL (2) | IL142536A0 (de) |
| MX (1) | MXPA03009342A (de) |
| NO (1) | NO20034557L (de) |
| NZ (1) | NZ528783A (de) |
| PL (1) | PL366696A1 (de) |
| WO (1) | WO2002083058A2 (de) |
| ZA (1) | ZA200307784B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL142535A0 (en) * | 2001-04-11 | 2002-03-10 | Yeda Res & Dev | Pharmaceutical compositions for the treatment of inflammation |
| EP1509618B1 (de) | 2002-05-13 | 2008-08-20 | Arexis AB | Autoimmunerkrankungen und nadph-oxidase-defekte |
| US8084049B2 (en) * | 2002-06-20 | 2011-12-27 | Astion Dermatology A/S | Complexes of fatty acid esters of polyhydroxyalkanes and pyridine carboxy derivatives |
| NZ539106A (en) * | 2002-10-10 | 2007-02-23 | Yeda Res & Dev | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents |
| US20050158329A1 (en) | 2004-01-21 | 2005-07-21 | Ghosh Swapan K. | Novel phytol derived immunoadjuvants and their use in vaccine formulations |
| EP1740169B1 (de) * | 2004-04-24 | 2012-09-05 | Enzychem Lifesciences Corporation | Immunomodulierendes mittel, antikrebsmittel und monoacetyldiacylglycerin enthaltende reformkost |
| KR100594972B1 (ko) * | 2004-11-06 | 2006-07-03 | 여진환 | 다목적 낚시용 의자 |
| WO2007015441A1 (ja) * | 2005-08-01 | 2007-02-08 | Hisamitsu Pharmaceutical Co., Inc. | 経皮または経粘膜投与のためのアジュバントおよび製剤 |
| WO2008093772A1 (ja) | 2007-01-31 | 2008-08-07 | Hisamitsu Pharmaceutical Co., Inc. | 経皮または経粘膜投与のためのアジュバントおよびこれを含む医薬製剤 |
| US20080221115A1 (en) * | 2007-02-26 | 2008-09-11 | Liat Hayardeny-Nisimov | Use of long-chain alcohol derivatives for the treatment of alopecia areata |
| US7964751B2 (en) | 2007-02-26 | 2011-06-21 | Yeda Research And Development Co. Ltd. | Enantiomers of amino-phenyl-acetic acid octadec-9-(Z) enyl ester, their salts and their uses |
| TWI576111B (zh) | 2011-02-25 | 2017-04-01 | 久光製藥股份有限公司 | 用於經皮或經黏膜投予之佐劑及含有該佐劑之醫藥製劑 |
| PL405505A1 (pl) * | 2013-09-30 | 2015-04-13 | Warszawski Uniwersytet Medyczny | Zastosowanie pochodnej kwasu diaminodikarboksylowego jako inhibitora aktywności biologicznej IL-15 I IL-2 |
| JP6114401B2 (ja) | 2013-10-31 | 2017-04-12 | 久光製薬株式会社 | アジュバント組成物、これを含むアジュバント製剤、及びキット |
| CN108853066A (zh) * | 2018-09-20 | 2018-11-23 | 成都中医药大学 | 链式脂肪醇在制备抗炎、镇痛药物中的用途 |
| CN112168812B (zh) * | 2019-07-02 | 2022-07-08 | 瑞微（深圳）生物科技有限公司 | 棕榈油酸用于制备预防或治疗炎症性疾病的组合物的用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2984764A (en) * | 1948-12-20 | 1961-05-16 | Raytheon Co | Electron discharge devices of the magnetron type |
| US3592930A (en) * | 1968-07-19 | 1971-07-13 | Syntex Corp | Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle |
| US4152423A (en) * | 1971-11-19 | 1979-05-01 | Agence Nationale De Valorisation De La Recherche (Anvar) | Immunological agents |
| US5540931A (en) * | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
| US5194451A (en) * | 1989-11-02 | 1993-03-16 | Katz David H | Systemic anti-inflammatory treatment |
| IE904098A1 (en) * | 1989-11-13 | 1991-05-22 | Nova Pharm Corp | Lipospheres for controlled delivery of substances |
| US5817629A (en) * | 1991-10-22 | 1998-10-06 | The Governors Of The University Of Alberta | Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients |
| WO1996028470A2 (en) * | 1995-03-09 | 1996-09-19 | Neurocrine Biosciences, Inc. | Peptide analogues of human myelin basic protein useful in treating multiple sclerosis |
| IL114458A0 (en) * | 1995-07-05 | 1995-11-27 | Yeda Res & Dev | Therapeutic preparations for treatment of T cell mediated diseases |
| EP0781559B1 (de) * | 1995-11-30 | 2007-02-07 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Öladjuvierter Impfstoff und Verfahren zu seiner Herstellung |
| TW355153B (en) * | 1996-05-21 | 1999-04-01 | Toshiba Machine Co Ltd | A method for leveling abrasive cloth and device for the same |
| ES2195175T3 (es) * | 1996-10-11 | 2003-12-01 | Scarista Ltd | Preparacion farmaceutica que comprende acido eicosapentaenoico y/o acido estearidonico. |
| US5910306A (en) * | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
| US6210700B1 (en) * | 1997-01-14 | 2001-04-03 | Novartis Nutrition Ag | Enhancement of transplant graft survival through nutritional immunomodulation with omega-9 fatty acid dietary supplement therapy |
| US6242426B1 (en) * | 1997-07-25 | 2001-06-05 | Avigen, Inc. | Induction of immune response to antigens expressed by recombinant adeno-associated virus |
| US6114337A (en) * | 1998-11-27 | 2000-09-05 | Pugliese; Peter T. | Zwitteronic-fatty acid compounds having anti-inflammatory properties |
| EP0919230A1 (de) * | 1997-12-01 | 1999-06-02 | Societe Des Produits Nestle S.A. | Verwendung des nmifa als Entzündungshemmer in oberflächlichem Saugetier-Gewebe |
| WO1999058120A1 (en) * | 1998-05-08 | 1999-11-18 | Rolf Berge | USE OF NON-β-OXIDIZABLE FATTY ACID ANALOGUES FOR TREATMENT OF SYNDROME-X CONDITIONS |
| US6118020A (en) * | 1999-05-19 | 2000-09-12 | Nexmed Holdings, Inc. | Crystalline salts of dodecyl 2-(N,N-dimethylamino)-propionate |
| IL142535A0 (en) * | 2001-04-11 | 2002-03-10 | Yeda Res & Dev | Pharmaceutical compositions for the treatment of inflammation |
| NZ539106A (en) * | 2002-10-10 | 2007-02-23 | Yeda Res & Dev | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents |
-
2001
- 2001-04-11 IL IL14253601A patent/IL142536A0/xx unknown
-
2002
- 2002-04-11 CN CNB028114884A patent/CN1327898C/zh not_active Expired - Fee Related
- 2002-04-11 CA CA002442943A patent/CA2442943A1/en not_active Abandoned
- 2002-04-11 KR KR10-2003-7013309A patent/KR20030096311A/ko not_active Abandoned
- 2002-04-11 US US10/474,448 patent/US20040247604A1/en not_active Abandoned
- 2002-04-11 NZ NZ528783A patent/NZ528783A/en unknown
- 2002-04-11 WO PCT/IL2002/000295 patent/WO2002083058A2/en not_active Ceased
- 2002-04-11 PL PL02366696A patent/PL366696A1/xx not_active Application Discontinuation
- 2002-04-11 EP EP02761953A patent/EP1408951B1/de not_active Expired - Lifetime
- 2002-04-11 AT AT02761953T patent/ATE453409T1/de not_active IP Right Cessation
- 2002-04-11 MX MXPA03009342A patent/MXPA03009342A/es active IP Right Grant
- 2002-04-11 AU AU2002307767A patent/AU2002307767B2/en not_active Ceased
- 2002-04-11 DE DE60234927T patent/DE60234927D1/de not_active Expired - Lifetime
- 2002-04-11 JP JP2002580863A patent/JP2004526757A/ja active Pending
- 2002-04-11 HU HU0303796A patent/HUP0303796A3/hu unknown
-
2003
- 2003-10-02 IL IL158226A patent/IL158226A/en not_active IP Right Cessation
- 2003-10-06 ZA ZA200307784A patent/ZA200307784B/en unknown
- 2003-10-10 NO NO20034557A patent/NO20034557L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0303796A3 (en) | 2011-03-28 |
| IL158226A (en) | 2008-11-03 |
| AU2002307767B2 (en) | 2007-08-30 |
| WO2002083058A3 (en) | 2004-02-26 |
| CN1327898C (zh) | 2007-07-25 |
| NZ528783A (en) | 2005-10-28 |
| EP1408951A2 (de) | 2004-04-21 |
| DE60234927D1 (de) | 2010-02-11 |
| ZA200307784B (en) | 2004-10-06 |
| NO20034557L (no) | 2003-12-05 |
| EP1408951B1 (de) | 2009-12-30 |
| CA2442943A1 (en) | 2002-10-24 |
| HUP0303796A2 (hu) | 2004-03-01 |
| KR20030096311A (ko) | 2003-12-24 |
| CN1514736A (zh) | 2004-07-21 |
| PL366696A1 (en) | 2005-02-07 |
| NO20034557D0 (no) | 2003-10-10 |
| JP2004526757A (ja) | 2004-09-02 |
| MXPA03009342A (es) | 2004-02-12 |
| IL142536A0 (en) | 2002-03-10 |
| WO2002083058A2 (en) | 2002-10-24 |
| EP1408951A4 (de) | 2004-08-18 |
| US20040247604A1 (en) | 2004-12-09 |
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