ATE447406T1 - 1h-indol-pyridincarbonsäureamid und 1h-indol- piperidincarbonsäureamid-derivate und ihre verwendung als tyrosin hydroxylase-induktoren - Google Patents

1h-indol-pyridincarbonsäureamid und 1h-indol- piperidincarbonsäureamid-derivate und ihre verwendung als tyrosin hydroxylase-induktoren

Info

Publication number
ATE447406T1
ATE447406T1 AT06778790T AT06778790T ATE447406T1 AT E447406 T1 ATE447406 T1 AT E447406T1 AT 06778790 T AT06778790 T AT 06778790T AT 06778790 T AT06778790 T AT 06778790T AT E447406 T1 ATE447406 T1 AT E447406T1
Authority
AT
Austria
Prior art keywords
indole
acid amide
pyridinecarbonic
inductors
piperidine
Prior art date
Application number
AT06778790T
Other languages
English (en)
Inventor
Jean-Daniel Brion
Fabrice Bintein
Rodolphe Razet
Patrick Razon
Zafiarisoa Renko
Eric Levoirier
Jean-Francois Pujol
Dinah Weissmann
Ridant Alain Le
Catherine Harpey
Original Assignee
Servier Lab
Centre Nat Rech Scient
Univ Paris Sud 11
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Centre Nat Rech Scient, Univ Paris Sud 11 filed Critical Servier Lab
Application granted granted Critical
Publication of ATE447406T1 publication Critical patent/ATE447406T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AT06778790T 2005-07-07 2006-07-06 1h-indol-pyridincarbonsäureamid und 1h-indol- piperidincarbonsäureamid-derivate und ihre verwendung als tyrosin hydroxylase-induktoren ATE447406T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0507225A FR2888238B1 (fr) 2005-07-07 2005-07-07 Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
PCT/FR2006/001610 WO2007006922A2 (fr) 2005-07-07 2006-07-06 Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide et leur utilisation comme inducteurs de tyrosine hydroxylase

Publications (1)

Publication Number Publication Date
ATE447406T1 true ATE447406T1 (de) 2009-11-15

Family

ID=35954102

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06778790T ATE447406T1 (de) 2005-07-07 2006-07-06 1h-indol-pyridincarbonsäureamid und 1h-indol- piperidincarbonsäureamid-derivate und ihre verwendung als tyrosin hydroxylase-induktoren

Country Status (25)

Country Link
US (1) US20090258883A1 (de)
EP (1) EP1931341B1 (de)
JP (1) JP2009500380A (de)
KR (1) KR20080027925A (de)
CN (1) CN101257905A (de)
AR (1) AR054862A1 (de)
AT (1) ATE447406T1 (de)
AU (1) AU2006268527B2 (de)
BR (1) BRPI0612684A2 (de)
CA (1) CA2614000A1 (de)
DE (1) DE602006010221D1 (de)
DK (1) DK1931341T3 (de)
EA (1) EA014022B1 (de)
ES (1) ES2336250T3 (de)
FR (1) FR2888238B1 (de)
GE (1) GEP20104963B (de)
HR (1) HRP20100010T1 (de)
MA (1) MA29616B1 (de)
NO (1) NO20080677L (de)
PL (1) PL1931341T3 (de)
PT (1) PT1931341E (de)
SI (1) SI1931341T1 (de)
UA (1) UA89544C2 (de)
WO (1) WO2007006922A2 (de)
ZA (1) ZA200800833B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2926077A1 (fr) * 2008-01-04 2009-07-10 Servier Lab Nouveaux derives d'1h-indol-1-yl uree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
EP3202758A1 (de) * 2016-02-03 2017-08-09 Evonik Degussa GmbH Reduktive alkylierung von aminen mit orthocarbonsäureestern

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4204998A (en) * 1974-03-28 1980-05-27 Siegfried Aktiengesellschaft N-Amino indole derivatives having pharmacological activity
ATE115143T1 (de) * 1987-04-24 1994-12-15 Hoechst Roussel Pharma N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel.
CA2017621A1 (en) * 1989-06-23 1990-12-23 Masayuki Kato Indole derivatives and processes for preparation thereof
US5102891A (en) * 1990-07-23 1992-04-07 Hoechst-Roussel Pharmaceuticals Inc. 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates
US5319096A (en) * 1992-04-03 1994-06-07 Hoechst-Roussel Pharmaceuticals Inc. (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
FR2713644B1 (fr) * 1993-12-14 1996-02-09 Adir Nouveaux analogues de l'éburnane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
GB9710523D0 (en) * 1997-05-23 1997-07-16 Smithkline Beecham Plc Novel compounds
US6084098A (en) * 1999-02-26 2000-07-04 Neurogen Corporation Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands

Also Published As

Publication number Publication date
PT1931341E (pt) 2009-11-30
GEP20104963B (en) 2010-04-26
US20090258883A1 (en) 2009-10-15
MA29616B1 (fr) 2008-07-01
EP1931341B1 (de) 2009-11-04
ES2336250T3 (es) 2010-04-09
WO2007006922A2 (fr) 2007-01-18
KR20080027925A (ko) 2008-03-28
CA2614000A1 (fr) 2007-01-18
ZA200800833B (en) 2009-04-29
NO20080677L (no) 2008-02-06
FR2888238B1 (fr) 2007-09-07
EP1931341A2 (de) 2008-06-18
HRP20100010T1 (hr) 2010-03-31
AU2006268527B2 (en) 2009-12-24
DK1931341T3 (da) 2010-03-15
PL1931341T3 (pl) 2010-06-30
EA014022B1 (ru) 2010-08-30
WO2007006922A8 (fr) 2008-01-10
JP2009500380A (ja) 2009-01-08
SI1931341T1 (sl) 2010-03-31
DE602006010221D1 (de) 2009-12-17
FR2888238A1 (fr) 2007-01-12
EA200800208A1 (ru) 2008-08-29
BRPI0612684A2 (pt) 2010-11-30
UA89544C2 (uk) 2010-02-10
WO2007006922A3 (fr) 2007-04-05
AR054862A1 (es) 2007-07-25
AU2006268527A1 (en) 2007-01-18
CN101257905A (zh) 2008-09-03

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