ATE445419T1 - Festphase fluorierung von benzothiazole - Google Patents

Festphase fluorierung von benzothiazole

Info

Publication number
ATE445419T1
ATE445419T1 AT03782655T AT03782655T ATE445419T1 AT E445419 T1 ATE445419 T1 AT E445419T1 AT 03782655 T AT03782655 T AT 03782655T AT 03782655 T AT03782655 T AT 03782655T AT E445419 T1 ATE445419 T1 AT E445419T1
Authority
AT
Austria
Prior art keywords
tracer
fluoration
benzothiazoles
solid phase
formula
Prior art date
Application number
AT03782655T
Other languages
English (en)
Inventor
Frank Brady
Sajinder Kaur Luthra
Alexander Mark Gibson
Original Assignee
Ge Healthcare Ltd
Hammersmith Imanet Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd, Hammersmith Imanet Ltd filed Critical Ge Healthcare Ltd
Application granted granted Critical
Publication of ATE445419T1 publication Critical patent/ATE445419T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Glass Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT03782655T 2002-12-20 2003-12-19 Festphase fluorierung von benzothiazole ATE445419T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0229686.1A GB0229686D0 (en) 2002-12-20 2002-12-20 Solid-phase fluorination of benzothiazoles
PCT/GB2003/005574 WO2004056399A2 (en) 2002-12-20 2003-12-19 Solid-phase fluorination of benzothiazoles

Publications (1)

Publication Number Publication Date
ATE445419T1 true ATE445419T1 (de) 2009-10-15

Family

ID=9950060

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03782655T ATE445419T1 (de) 2002-12-20 2003-12-19 Festphase fluorierung von benzothiazole

Country Status (9)

Country Link
US (2) US8323616B2 (de)
EP (1) EP1572248B1 (de)
JP (1) JP2006510705A (de)
AT (1) ATE445419T1 (de)
AU (1) AU2003290293A1 (de)
DE (1) DE60329706D1 (de)
ES (1) ES2334345T3 (de)
GB (1) GB0229686D0 (de)
WO (1) WO2004056399A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1334091T3 (da) 2000-08-24 2012-10-15 Univ Pittsburgh Thioflavinderivater og deres anvendelse til diagnose og terapi af Alzheimer's sygdom
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
RU2440995C2 (ru) * 2003-03-14 2012-01-27 Юнивесити Оф Питсбэг Производные бензотиазола, фармацевтическая композиция, обладающая свойством связывать амилоид, и способ детекции отложений амилоида у млекопитающего
US8435492B2 (en) * 2003-05-02 2013-05-07 University Of Western Ontario Prosthetic groups attached to stannyl polymer in the synthesis of radiopharmaceuticals
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
US20050049487A1 (en) * 2003-08-26 2005-03-03 Johnson Bruce Fletcher Compounds and kits for preparing imaging agents and methods of imaging
GB0516564D0 (en) * 2005-08-12 2005-09-21 Ge Healthcare Ltd Fluorination process
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
PL2247558T3 (pl) 2008-02-14 2022-05-02 Eli Lilly And Company Nowe środki obrazujące do wykrywania czynnościowych zaburzeń neurologicznych
EP2303897A4 (de) * 2008-06-05 2012-02-22 Harvard College Hochvalente palladiumfluoridkomplexe und anwendungen davon
EP2323697A2 (de) 2008-07-24 2011-05-25 Siemens Medical Solutions USA, Inc. Bildgebungsmittel zur erkennung einer ad-pathologie
JP2012509351A (ja) 2008-11-20 2012-04-19 プレジデント アンド フェローズ オブ ハーバード カレッジ 有機化合物のフッ素化
WO2010081036A2 (en) * 2009-01-09 2010-07-15 President And Fellows Of Harvard College Fluorine containing compounds and methods of use thereof
US8691187B2 (en) 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
WO2010111303A2 (en) 2009-03-23 2010-09-30 Siemens Medical Solutions Usa, Inc. Imaging agents for detecting neurological disorders
EP2697204B1 (de) 2011-04-12 2017-03-08 President and Fellows of Harvard College Fluorierung organischer verbindungen
GB201120586D0 (en) * 2011-11-30 2012-01-11 Ge Healthcare Ltd Solid phase extraction neutralisation
US9856182B2 (en) 2012-07-30 2018-01-02 Technical University Of Denmark Radiofluorination method
US9273083B2 (en) 2012-09-26 2016-03-01 President And Fellows Of Harvard College Nickel fluorinating complexes and uses thereof
WO2015058047A2 (en) 2013-10-18 2015-04-23 President And Fellows Of Harvard College Fluorination of organic compounds
JP6485914B2 (ja) * 2015-10-28 2019-03-20 日本メジフィジックス株式会社 フルテメタモルの製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3307364A1 (de) * 1983-03-02 1984-09-06 Hoechst Ag, 6230 Frankfurt Zweikomponenten-diazontypiematerial
US5312592A (en) * 1990-06-13 1994-05-17 Scanditronix Ab Disposable kit for preparation
BE1010280A3 (fr) 1996-05-02 1998-05-05 Coincidence S A Procede et dispositif de synthese de 2-[18f] fluoro-2-deoxy-d-glucose.
WO1999018053A1 (en) * 1997-10-02 1999-04-15 The University Of Western Ontario Preparation of radiolabelled haloaromatics via polymer-bound intermediates
GB9919673D0 (en) 1999-08-20 1999-10-20 Cancer Res Campaign Tech 2-Arlybenzazole compounds
DK1334091T3 (da) 2000-08-24 2012-10-15 Univ Pittsburgh Thioflavinderivater og deres anvendelse til diagnose og terapi af Alzheimer's sygdom
JP4190290B2 (ja) * 2001-03-02 2008-12-03 ユニバーシティー オブ ウエスタン オンタリオ 放射能標識された化合物のポリマー前駆体、ならびにその作製および使用法
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0115929D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase electrophilic fluorination
AU2003212490A1 (en) 2002-02-13 2003-09-04 Amersham Plc Benzothiazole derivatives for in vivo imaging of amyloid plaques

Also Published As

Publication number Publication date
EP1572248B1 (de) 2009-10-14
JP2006510705A (ja) 2006-03-30
WO2004056399A2 (en) 2004-07-08
WO2004056399A3 (en) 2004-09-23
AU2003290293A8 (en) 2004-07-14
US20060083677A1 (en) 2006-04-20
GB0229686D0 (en) 2003-01-29
ES2334345T3 (es) 2010-03-09
US20130089501A1 (en) 2013-04-11
AU2003290293A1 (en) 2004-07-14
DE60329706D1 (de) 2009-11-26
US8323616B2 (en) 2012-12-04
EP1572248A2 (de) 2005-09-14

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