ATE445161T1 - Rekombinantes zellsystem zur deorphanisierung von g protein-gekoppelten rezeptoren - Google Patents
Rekombinantes zellsystem zur deorphanisierung von g protein-gekoppelten rezeptorenInfo
- Publication number
- ATE445161T1 ATE445161T1 AT04790869T AT04790869T ATE445161T1 AT E445161 T1 ATE445161 T1 AT E445161T1 AT 04790869 T AT04790869 T AT 04790869T AT 04790869 T AT04790869 T AT 04790869T AT E445161 T1 ATE445161 T1 AT E445161T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- coupled receptors
- deorphanization
- cell system
- recombinant cell
- Prior art date
Links
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 title abstract 3
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 title abstract 3
- 230000001413 cellular effect Effects 0.000 abstract 3
- 108091006027 G proteins Proteins 0.000 abstract 1
- 102000030782 GTP binding Human genes 0.000 abstract 1
- 108091000058 GTP-Binding Proteins 0.000 abstract 1
- 101000875054 Homo sapiens Cyclic nucleotide-gated olfactory channel Proteins 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2003150054 DE10350054B4 (de) | 2003-10-27 | 2003-10-27 | Rekombinantes Zellsystem zur Deorphansisierung von G Protein-gekoppelten Rezeptoren |
| DE102004019028 | 2004-04-20 | ||
| PCT/EP2004/012086 WO2005043158A1 (de) | 2003-10-27 | 2004-10-26 | Rekombinantes zellsystem zur deorphanisierung von g protein-gekoppelten rezeptoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE445161T1 true ATE445161T1 (de) | 2009-10-15 |
Family
ID=34553314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04790869T ATE445161T1 (de) | 2003-10-27 | 2004-10-26 | Rekombinantes zellsystem zur deorphanisierung von g protein-gekoppelten rezeptoren |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20070105158A1 (de) |
| EP (1) | EP1680678B1 (de) |
| AT (1) | ATE445161T1 (de) |
| DE (1) | DE502004010211D1 (de) |
| WO (1) | WO2005043158A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2108954A1 (de) | 2008-04-10 | 2009-10-14 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Testsystem zur Erkennung eines intrazellulären zyklischen Nukleotidspiegels sowie Verfahren dafür und Verwendungen davon |
| JP6434661B2 (ja) * | 2017-02-02 | 2018-12-05 | 花王株式会社 | 匂い制御物質の選択方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000035274A1 (en) * | 1998-12-17 | 2000-06-22 | The Johns Hopkins University School Of Medicine | Olfactory receptor expression libraries and methods of making and using them |
| IL159242A0 (en) * | 2001-07-06 | 2004-06-01 | Senomyx Inc | Expression of functional human olfactory cyclic nucleotide gated (cng) channel in recombinant host cells and use thereof in cell based assays to identify smell modulators |
-
2004
- 2004-10-26 US US10/577,094 patent/US20070105158A1/en not_active Abandoned
- 2004-10-26 DE DE502004010211T patent/DE502004010211D1/de not_active Expired - Fee Related
- 2004-10-26 WO PCT/EP2004/012086 patent/WO2005043158A1/de not_active Ceased
- 2004-10-26 AT AT04790869T patent/ATE445161T1/de not_active IP Right Cessation
- 2004-10-26 EP EP04790869A patent/EP1680678B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005043158A1 (de) | 2005-05-12 |
| US20070105158A1 (en) | 2007-05-10 |
| EP1680678A1 (de) | 2006-07-19 |
| DE502004010211D1 (de) | 2009-11-19 |
| EP1680678B1 (de) | 2009-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |