ATE434038T1 - Mutierte abl-kinase-domänen - Google Patents

Mutierte abl-kinase-domänen

Info

Publication number
ATE434038T1
ATE434038T1 AT02782829T AT02782829T ATE434038T1 AT E434038 T1 ATE434038 T1 AT E434038T1 AT 02782829 T AT02782829 T AT 02782829T AT 02782829 T AT02782829 T AT 02782829T AT E434038 T1 ATE434038 T1 AT E434038T1
Authority
AT
Austria
Prior art keywords
polypeptides
kinase domain
amino acid
nucleic acid
acid molecules
Prior art date
Application number
AT02782829T
Other languages
English (en)
Inventor
Christophe Barthe
Susan Branford
Amie Corbin
Brian Druker
Justus Duyster
Andreas Hochhaus
Timothy Hughes
Sebastian Kreil
Thibaut Leguay
Francois-Xavier Mahon
Gerald Marit
Martin Mueller
Christian Peschel
Claude Preudhomme
Lestienne Catherine Roche
Zbigniew Rudzki
Original Assignee
Novartis Ag
Univ Victor Segalen Bordeaux 2
Univ Muenchen Tech
Univ Oregon Health & Science
Univ Heidelberg
Chru De Lille Ct Hospitalier R
Medvet Science Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Victor Segalen Bordeaux 2, Univ Muenchen Tech, Univ Oregon Health & Science, Univ Heidelberg, Chru De Lille Ct Hospitalier R, Medvet Science Pty Ltd filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE434038T1 publication Critical patent/ATE434038T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT02782829T 2001-10-05 2002-10-04 Mutierte abl-kinase-domänen ATE434038T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32738901P 2001-10-05 2001-10-05
US32874001P 2001-10-12 2001-10-12
US34735102P 2002-01-11 2002-01-11
PCT/EP2002/011144 WO2003031608A2 (en) 2001-10-05 2002-10-04 Mutated abl kinase domains

Publications (1)

Publication Number Publication Date
ATE434038T1 true ATE434038T1 (de) 2009-07-15

Family

ID=27406519

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02782829T ATE434038T1 (de) 2001-10-05 2002-10-04 Mutierte abl-kinase-domänen
AT08166771T ATE490308T1 (de) 2001-10-05 2002-10-04 Mutante der kinase domäne des abl

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT08166771T ATE490308T1 (de) 2001-10-05 2002-10-04 Mutante der kinase domäne des abl

Country Status (7)

Country Link
US (4) US20050202519A1 (de)
EP (8) EP2341133A1 (de)
JP (2) JP4243191B2 (de)
AT (2) ATE434038T1 (de)
DE (2) DE60232670D1 (de)
PT (1) PT2017335E (de)
WO (1) WO2003031608A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2753372C (en) * 2001-06-14 2018-08-07 The Regents Of The University Of California Mutations in the bcr-abl tyrosine kinase associated with resistance to sti-571
GB0201384D0 (en) * 2002-01-22 2002-03-13 European Molecular Biology Lab Embl Tyrosine kinase inhibitors
US20050148605A1 (en) 2003-11-13 2005-07-07 Ambit Biosciences Corporation Amide derivatives as ABL modulators
CN103356636A (zh) 2004-05-23 2013-10-23 杰勒德·M·豪斯 Theramutein调节剂
WO2007014250A2 (en) * 2005-07-26 2007-02-01 Vertex Pharmaceuticals Incorporated Abl kinase inhibition
WO2007058991A2 (en) * 2005-11-14 2007-05-24 Novartis Ag Mutations and polymorphisms of c-abl
WO2007062213A2 (en) 2005-11-23 2007-05-31 Housey Pharmaceuticals Inc Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators
EP3002009B1 (de) 2007-06-01 2021-07-07 Wyeth LLC Behandlung von imatinib-resistenter chronischer myelogener leukämie mit der mutation 1457t>c im bcrabl gen unter verwendung der verbindung bosutinib
US9232968B2 (en) 2007-12-19 2016-01-12 DePuy Synthes Products, Inc. Polymeric pedicle rods and methods of manufacturing
US8586310B2 (en) 2008-09-05 2013-11-19 Washington University Method for multiplexed nucleic acid patch polymerase chain reaction
US11111514B2 (en) 2008-09-05 2021-09-07 Washington University Method for multiplexed nucleic acid patch polymerase chain reaction
US9909170B2 (en) 2008-09-05 2018-03-06 Washington University Method for multiplexed nucleic acid patch polymerase chain reaction
US9702877B2 (en) * 2008-10-31 2017-07-11 Quest Diagnostics Investments Incorporated BCR-ABL variants
US8641734B2 (en) 2009-02-13 2014-02-04 DePuy Synthes Products, LLC Dual spring posterior dynamic stabilization device with elongation limiting elastomers
US9320543B2 (en) 2009-06-25 2016-04-26 DePuy Synthes Products, Inc. Posterior dynamic stabilization device having a mobile anchor
US9488656B2 (en) 2009-09-30 2016-11-08 Quest Diagnostics Investments Incorporated BCR-ABL truncation mutations
JP5359924B2 (ja) * 2010-02-18 2013-12-04 株式会社島津製作所 質量分析装置
US9445844B2 (en) 2010-03-24 2016-09-20 DePuy Synthes Products, Inc. Composite material posterior dynamic stabilization spring rod
US8603740B2 (en) 2010-12-29 2013-12-10 Quest Diagnostics Investments Incorporated BCR-ABL1 splice variants and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW225528B (de) 1992-04-03 1994-06-21 Ciba Geigy Ag
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
CA2753372C (en) * 2001-06-14 2018-08-07 The Regents Of The University Of California Mutations in the bcr-abl tyrosine kinase associated with resistance to sti-571
US20030170851A1 (en) * 2001-10-05 2003-09-11 Christophe Barthe Organic compounds

Also Published As

Publication number Publication date
EP2343367A1 (de) 2011-07-13
ATE490308T1 (de) 2010-12-15
EP1436384B1 (de) 2009-06-17
EP2343366A1 (de) 2011-07-13
US20050202519A1 (en) 2005-09-15
WO2003031608A3 (en) 2003-12-18
EP2290056A3 (de) 2011-06-01
DE60238511D1 (de) 2011-01-13
EP2341133A1 (de) 2011-07-06
JP2005504549A (ja) 2005-02-17
EP2017335A1 (de) 2009-01-21
PT2017335E (pt) 2011-03-02
EP2246416A1 (de) 2010-11-03
EP2343365A1 (de) 2011-07-13
US20090117641A1 (en) 2009-05-07
EP2017335B1 (de) 2010-12-01
JP4243191B2 (ja) 2009-03-25
WO2003031608A2 (en) 2003-04-17
US20100021920A1 (en) 2010-01-28
US20100021921A1 (en) 2010-01-28
EP2290056A2 (de) 2011-03-02
JP2009165464A (ja) 2009-07-30
EP1436384A2 (de) 2004-07-14
DE60232670D1 (de) 2009-07-30

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