ATE433988T1 - Phosphoramidatderivate - Google Patents
PhosphoramidatderivateInfo
- Publication number
- ATE433988T1 ATE433988T1 AT05701927T AT05701927T ATE433988T1 AT E433988 T1 ATE433988 T1 AT E433988T1 AT 05701927 T AT05701927 T AT 05701927T AT 05701927 T AT05701927 T AT 05701927T AT E433988 T1 ATE433988 T1 AT E433988T1
- Authority
- AT
- Austria
- Prior art keywords
- phosphoramidate derivatives
- ester
- present
- provides
- phosphoramidate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0401088.0A GB0401088D0 (en) | 2004-01-19 | 2004-01-19 | Phosphoramidate derivatives |
PCT/GB2005/000161 WO2005070944A1 (en) | 2004-01-19 | 2005-01-18 | Phosphoramidate derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE433988T1 true ATE433988T1 (de) | 2009-07-15 |
Family
ID=31726385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05701927T ATE433988T1 (de) | 2004-01-19 | 2005-01-18 | Phosphoramidatderivate |
Country Status (9)
Country | Link |
---|---|
US (1) | US8119779B2 (de) |
EP (1) | EP1709056B1 (de) |
JP (1) | JP5137403B2 (de) |
AT (1) | ATE433988T1 (de) |
DE (1) | DE602005014936D1 (de) |
DK (1) | DK1709056T3 (de) |
ES (1) | ES2328495T3 (de) |
GB (1) | GB0401088D0 (de) |
WO (1) | WO2005070944A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
MXPA05005192A (es) | 2002-11-15 | 2005-09-08 | Idenix Cayman Ltd | Nucleosidos ramificados en la posicion 2' y mutacion de flaviviridae. |
GB0401088D0 (en) | 2004-01-19 | 2004-02-18 | Univ Cardiff | Phosphoramidate derivatives |
GB0505781D0 (en) | 2005-03-21 | 2005-04-27 | Univ Cardiff | Chemical compounds |
EP2471802A1 (de) | 2010-12-27 | 2012-07-04 | Bioiberica, S.A. | Phosphoramidate aus Monosacchariden |
WO2012154321A1 (en) | 2011-03-31 | 2012-11-15 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
GB201111779D0 (en) | 2011-07-08 | 2011-08-24 | Univ Cardiff | Chemical compounds |
US9403863B2 (en) | 2011-09-12 | 2016-08-02 | Idenix Pharmaceuticals Llc | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
US8507460B2 (en) | 2011-10-14 | 2013-08-13 | Idenix Pharmaceuticals, Inc. | Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
US9296778B2 (en) | 2012-05-22 | 2016-03-29 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphate prodrugs for HCV infection |
US9109001B2 (en) | 2012-05-22 | 2015-08-18 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphoramidate prodrugs for HCV infection |
JP6165848B2 (ja) | 2012-05-22 | 2017-07-19 | イデニク ファーマシューティカルズ エルエルシー | 肝疾患のためのd−アミノ酸化合物 |
CA2871547C (en) | 2012-05-25 | 2021-05-25 | Janssen R&D Ireland | Uracyl spirooxetane nucleosides |
WO2014052638A1 (en) | 2012-09-27 | 2014-04-03 | Idenix Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
AU2013329521B2 (en) | 2012-10-08 | 2018-04-19 | Centre National De La Recherche Scientifique | 2'-chloro nucleoside analogs for HCV infection |
EP2909222B1 (de) | 2012-10-22 | 2021-05-26 | Idenix Pharmaceuticals LLC | 2',4'-verbrückten nukleoside für hcv-infektion |
WO2014099941A1 (en) | 2012-12-19 | 2014-06-26 | Idenix Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
WO2014137926A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | 3'-deoxy nucleosides for the treatment of hcv |
US20140271547A1 (en) | 2013-03-13 | 2014-09-18 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
US9187515B2 (en) | 2013-04-01 | 2015-11-17 | Idenix Pharmaceuticals Llc | 2′,4′-fluoro nucleosides for the treatment of HCV |
WO2014197578A1 (en) | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
EP3027636B1 (de) | 2013-08-01 | 2022-01-05 | Idenix Pharmaceuticals LLC | D-amino acid phosphoramidate pronucleotide of halogenierte pyrimidine verbindungen für leber krankheiten |
WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
US9828410B2 (en) | 2015-03-06 | 2017-11-28 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment |
LU100724B1 (en) | 2016-07-14 | 2018-07-31 | Atea Pharmaceuticals Inc | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
EP4088725A1 (de) | 2016-09-07 | 2022-11-16 | ATEA Pharmaceuticals, Inc. | 2'-substituierte-n6-substituierte purinnukleotide zur behandlung von picornaviridae |
WO2019118486A1 (en) * | 2017-12-11 | 2019-06-20 | Cerecor Inc. | Monosaccharide phosphoramidate prodrugs |
JP7147781B2 (ja) | 2018-06-19 | 2022-10-05 | 住友ゴム工業株式会社 | 重荷重用空気入りタイヤ |
WO2021173713A1 (en) | 2020-02-27 | 2021-09-02 | Atea Pharmaceuticals, Inc. | Highly active compounds against covid-19 |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2059272A1 (en) * | 1990-04-12 | 1991-10-13 | Akira Hasegawa | 4,6-0-hydroxyphosphoryl-glucosamine derivatives |
US6025344A (en) | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Certain dioic acid derivatives useful as NAALADase inhibitors |
US6046180A (en) | 1996-06-17 | 2000-04-04 | Guilford Pharmaceuticals Inc. | NAALADase inhibitors |
ATE212661T1 (de) * | 1998-01-23 | 2002-02-15 | Newbiotics Inc | Durch enzymkatalyse erhaltene therapeutische substanzen. |
US6030957A (en) | 1998-06-29 | 2000-02-29 | Wayne Hughes Institute | Aryl phosphate derivatives of d4T having anti-HIV activity |
GB9821058D0 (en) | 1998-09-28 | 1998-11-18 | Univ Cardiff | Chemical compound |
CN1346360A (zh) | 1999-02-12 | 2002-04-24 | 葛兰素集团有限公司 | 作为抗病毒剂的(1r,顺式)-4-(6-氨基-9h-嘌呤-9-基)-2-环戊烯-1-甲醇的氨基磷酸酯及一二和三磷酸酯 |
CA2317305A1 (en) * | 2000-08-29 | 2002-02-28 | Tassos P. Anastassiades | Method of enhancing chondrocyte cell growth and glycosaminoglycan production |
GB0401088D0 (en) | 2004-01-19 | 2004-02-18 | Univ Cardiff | Phosphoramidate derivatives |
-
2004
- 2004-01-19 GB GBGB0401088.0A patent/GB0401088D0/en not_active Ceased
-
2005
- 2005-01-18 ES ES05701927T patent/ES2328495T3/es active Active
- 2005-01-18 JP JP2006548408A patent/JP5137403B2/ja not_active Expired - Fee Related
- 2005-01-18 DK DK05701927T patent/DK1709056T3/da active
- 2005-01-18 US US10/586,101 patent/US8119779B2/en not_active Expired - Fee Related
- 2005-01-18 EP EP05701927A patent/EP1709056B1/de not_active Not-in-force
- 2005-01-18 AT AT05701927T patent/ATE433988T1/de not_active IP Right Cessation
- 2005-01-18 DE DE602005014936T patent/DE602005014936D1/de active Active
- 2005-01-18 WO PCT/GB2005/000161 patent/WO2005070944A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
DE602005014936D1 (en) | 2009-07-30 |
WO2005070944A1 (en) | 2005-08-04 |
DK1709056T3 (da) | 2009-08-10 |
US20070275910A1 (en) | 2007-11-29 |
GB0401088D0 (en) | 2004-02-18 |
EP1709056A1 (de) | 2006-10-11 |
JP2007518734A (ja) | 2007-07-12 |
EP1709056B1 (de) | 2009-06-17 |
JP5137403B2 (ja) | 2013-02-06 |
ES2328495T3 (es) | 2009-11-13 |
US8119779B2 (en) | 2012-02-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE433988T1 (de) | Phosphoramidatderivate | |
AR110313A2 (es) | Derivados de tiazol-2-il-pirrolidina | |
HRP20090113T3 (en) | C-aryl glucoside sglt2 inhibitors and method for their production | |
TNSN08191A1 (en) | Kinase inhibitors | |
RS52274B (en) | UNIT DIARYLHIDANTOIN | |
WO2005074603A3 (en) | Aminobenzoxazoles as therapeutic agents | |
TW200642689A (en) | Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient | |
GB0521508D0 (en) | Organic compounds | |
WO2005110410A3 (en) | Kinase inhibitors as therapeutic agents | |
TW200728307A (en) | Novel spirochromanone derivatives | |
TW200508228A (en) | Biaryl heterocyclic compounds and methods of making and using the same | |
RS52323B (en) | 2'-FLUORO-2'-DEOKSITETRAHIDROURIDINI KAO INHIBITORI CITIDIN DEAMINAZE | |
AU2006304874A8 (en) | Pyrimidinones as casein kinase II (CK2) modulators | |
WO2007148185A3 (en) | Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors | |
WO2007117465A3 (en) | Indazole compounds | |
RS52874B (en) | THYOPHEN ANALYSIS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | |
WO2006047528A3 (en) | Pyrazolobenzamides and derivatives as factor xa inhibitors | |
DE602007011902D1 (de) | Spiroindolinon-derivate | |
WO2007084728A3 (en) | 2-imino-benzimidazoles | |
GT200300087A (es) | 2-(2,6-diclorofenil)-diarilimidazoles | |
WO2007023342A3 (en) | Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof | |
EP1831239B8 (de) | Verfahren zur herstellung von 17-hydroxy-6 beta, 7 beta, 15 beta,16 beta-bismethylen-17alpha-pregn-4-en-3-on-21-carbonsäure gamma-lacton und schlüsselzwischenprodukte für dieses verfahren | |
PL371127A1 (en) | 6-aminomorphinane derivatives, method for the production and use thereof | |
NO20084543L (no) | Benzimidazolderivater | |
WO2006083841A3 (en) | Therapeutic esters |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |