ATE428783T1 - Expressionssystem für sirna - Google Patents
Expressionssystem für sirnaInfo
- Publication number
- ATE428783T1 ATE428783T1 AT04770721T AT04770721T ATE428783T1 AT E428783 T1 ATE428783 T1 AT E428783T1 AT 04770721 T AT04770721 T AT 04770721T AT 04770721 T AT04770721 T AT 04770721T AT E428783 T1 ATE428783 T1 AT E428783T1
- Authority
- AT
- Austria
- Prior art keywords
- sirna
- expression system
- downstream
- rna
- gene
- Prior art date
Links
- 108020004459 Small interfering RNA Proteins 0.000 abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- 108091026838 U1 spliceosomal RNA Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 108091027963 non-coding RNA Proteins 0.000 abstract 1
- 102000042567 non-coding RNA Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Oscillators With Electromechanical Resonators (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000335A ITRM20030335A1 (it) | 2003-07-09 | 2003-07-09 | Sistema di espressione di sirna. |
| PCT/IT2004/000381 WO2005005634A2 (en) | 2003-07-09 | 2004-07-09 | siRNA EXPRESSION SYSTEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE428783T1 true ATE428783T1 (de) | 2009-05-15 |
Family
ID=29765906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04770721T ATE428783T1 (de) | 2003-07-09 | 2004-07-09 | Expressionssystem für sirna |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7947823B2 (de) |
| EP (1) | EP1644499B1 (de) |
| JP (1) | JP4762897B2 (de) |
| CN (1) | CN1820074A (de) |
| AT (1) | ATE428783T1 (de) |
| AU (1) | AU2004256322B2 (de) |
| CA (1) | CA2532019A1 (de) |
| DE (1) | DE602004020619D1 (de) |
| IT (1) | ITRM20030335A1 (de) |
| WO (1) | WO2005005634A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060040391A1 (en) * | 2004-08-20 | 2006-02-23 | Promega Corporation | RNA interference vectors |
| CN100357436C (zh) * | 2005-07-01 | 2007-12-26 | 中国人民解放军第三军医大学 | 抑制Stat3基因表达的siRNA及其制备方法 |
| EP2111457A2 (de) * | 2007-01-18 | 2009-10-28 | Plant Bioscience Limited (PBL) | Verfahren und zusammensetzungen zur modulation des mirna-pfades |
| CN109486813B (zh) * | 2018-10-10 | 2022-01-18 | 广州医科大学附属第二医院 | 一种用于修复TPP1基因Pre-mRNA异常剪接的U1-snRNA及其应用 |
| WO2025155923A1 (en) | 2024-01-17 | 2025-07-24 | The Broad Institute, Inc. | Aav capsid modifications that enable improved cns-wide gene delivery through interactions with the transferrin receptor |
| WO2025160155A1 (en) | 2024-01-22 | 2025-07-31 | The Broad Institute, Inc. | Epigenetic targeting of prion diseases |
| WO2025217163A2 (en) | 2024-04-08 | 2025-10-16 | The Broad Institute, Inc. | Novel aav capsids binding to human cd59 |
| WO2025217174A1 (en) | 2024-04-08 | 2025-10-16 | The Broad Institute, Inc. | Aav capsid modifications that enable improved cns-wide gene delivery through interactions with carbonic anhydrase iv |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6013447A (en) * | 1997-11-21 | 2000-01-11 | Innovir Laboratories, Inc. | Random intracellular method for obtaining optimally active nucleic acid molecules |
| DE10100586C1 (de) * | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
-
2003
- 2003-07-09 IT IT000335A patent/ITRM20030335A1/it unknown
-
2004
- 2004-07-09 US US10/564,020 patent/US7947823B2/en not_active Expired - Lifetime
- 2004-07-09 CA CA002532019A patent/CA2532019A1/en not_active Abandoned
- 2004-07-09 AU AU2004256322A patent/AU2004256322B2/en not_active Ceased
- 2004-07-09 JP JP2006518501A patent/JP4762897B2/ja not_active Expired - Fee Related
- 2004-07-09 EP EP04770721A patent/EP1644499B1/de not_active Expired - Lifetime
- 2004-07-09 CN CNA2004800194548A patent/CN1820074A/zh active Pending
- 2004-07-09 DE DE602004020619T patent/DE602004020619D1/de not_active Expired - Lifetime
- 2004-07-09 WO PCT/IT2004/000381 patent/WO2005005634A2/en not_active Ceased
- 2004-07-09 AT AT04770721T patent/ATE428783T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1644499B1 (de) | 2009-04-15 |
| US7947823B2 (en) | 2011-05-24 |
| ITRM20030335A1 (it) | 2005-01-10 |
| JP4762897B2 (ja) | 2011-08-31 |
| WO2005005634A3 (en) | 2005-02-24 |
| EP1644499A2 (de) | 2006-04-12 |
| WO2005005634A2 (en) | 2005-01-20 |
| AU2004256322B2 (en) | 2009-11-12 |
| CA2532019A1 (en) | 2005-01-20 |
| AU2004256322A1 (en) | 2005-01-20 |
| CN1820074A (zh) | 2006-08-16 |
| DE602004020619D1 (de) | 2009-05-28 |
| US20060217327A1 (en) | 2006-09-28 |
| ITRM20030335A0 (it) | 2003-07-09 |
| JP2007518393A (ja) | 2007-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |