ATE418334T1 - Enol-tautomer der 3-indol-brenztraubensäure in fester und im wesentlichen reiner form zur behandlung von erkrankungen des zentralen nervensystems - Google Patents
Enol-tautomer der 3-indol-brenztraubensäure in fester und im wesentlichen reiner form zur behandlung von erkrankungen des zentralen nervensystemsInfo
- Publication number
- ATE418334T1 ATE418334T1 AT03727938T AT03727938T ATE418334T1 AT E418334 T1 ATE418334 T1 AT E418334T1 AT 03727938 T AT03727938 T AT 03727938T AT 03727938 T AT03727938 T AT 03727938T AT E418334 T1 ATE418334 T1 AT E418334T1
- Authority
- AT
- Austria
- Prior art keywords
- enol tautomer
- pure form
- acid
- pyrufuric
- indole
- Prior art date
Links
- 150000002085 enols Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 2
- RSTKLPZEZYGQPY-UHFFFAOYSA-N 3-(indol-3-yl)pyruvic acid Chemical compound C1=CC=C2C(CC(=O)C(=O)O)=CNC2=C1 RSTKLPZEZYGQPY-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002RM000255A ITRM20020255A1 (it) | 2002-05-09 | 2002-05-09 | Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE418334T1 true ATE418334T1 (de) | 2009-01-15 |
Family
ID=11456293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03727938T ATE418334T1 (de) | 2002-05-09 | 2003-05-07 | Enol-tautomer der 3-indol-brenztraubensäure in fester und im wesentlichen reiner form zur behandlung von erkrankungen des zentralen nervensystems |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050208125A1 (de) |
| EP (1) | EP1501503B1 (de) |
| JP (1) | JP2005529146A (de) |
| KR (1) | KR20040108787A (de) |
| CN (1) | CN100588398C (de) |
| AT (1) | ATE418334T1 (de) |
| AU (1) | AU2003233183A1 (de) |
| CA (1) | CA2483991A1 (de) |
| DE (1) | DE60325468D1 (de) |
| IT (1) | ITRM20020255A1 (de) |
| WO (1) | WO2003094914A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020012373A1 (en) * | 2018-07-10 | 2020-01-16 | Polindols S.R.L.S. | New drugs chronic invalidating pathologies and to slow aging, based on a new metabolic tryptophan route and production process thereof |
| JP2023511678A (ja) * | 2020-01-24 | 2023-03-22 | 森永乳業株式会社 | 神経突起伸長改善用組成物 |
| US11319613B2 (en) | 2020-08-18 | 2022-05-03 | Enviro Metals, LLC | Metal refinement |
| CN115813919B (zh) * | 2022-12-08 | 2024-02-06 | 佛山市妇幼保健院 | 吲哚-3-丙酮酸或其药用盐在制备治疗乳腺癌药物中的应用 |
| CN118105381A (zh) * | 2023-02-27 | 2024-05-31 | 南方科技大学 | 吲哚-3-丙酮酸在制备治疗抗癌症药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1482844A (fr) * | 1964-12-31 | 1967-06-02 | Merck & Co Inc | Procédé de préparation de nouveaux acides 2-[2-(phénylalkyl substitué)-3-indolyl] aliphatiques inférieurs |
| FR2306693A1 (fr) * | 1975-04-11 | 1976-11-05 | Roussel Uclaf | Nouveaux derives du /9h/pyrido/3,4-b/ indole et leurs sels, procede de preparation et application a titre de medicaments |
| US4822812A (en) * | 1987-05-21 | 1989-04-18 | Merrell Dow Pharmaceuticals Inc. | β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition |
| IT1237472B (it) * | 1989-10-04 | 1993-06-07 | Polifarma Spa | Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico. |
| TW288010B (de) * | 1992-03-05 | 1996-10-11 | Pfizer |
-
2002
- 2002-05-09 IT IT2002RM000255A patent/ITRM20020255A1/it unknown
-
2003
- 2003-05-07 US US10/513,859 patent/US20050208125A1/en not_active Abandoned
- 2003-05-07 DE DE60325468T patent/DE60325468D1/de not_active Expired - Lifetime
- 2003-05-07 CA CA002483991A patent/CA2483991A1/en not_active Abandoned
- 2003-05-07 EP EP03727938A patent/EP1501503B1/de not_active Expired - Lifetime
- 2003-05-07 JP JP2004503000A patent/JP2005529146A/ja active Pending
- 2003-05-07 AT AT03727938T patent/ATE418334T1/de not_active IP Right Cessation
- 2003-05-07 CN CN03810540A patent/CN100588398C/zh not_active Expired - Fee Related
- 2003-05-07 KR KR10-2004-7018015A patent/KR20040108787A/ko not_active Ceased
- 2003-05-07 WO PCT/IT2003/000275 patent/WO2003094914A1/en not_active Ceased
- 2003-05-07 AU AU2003233183A patent/AU2003233183A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005529146A (ja) | 2005-09-29 |
| CA2483991A1 (en) | 2003-11-20 |
| EP1501503B1 (de) | 2008-12-24 |
| WO2003094914A1 (en) | 2003-11-20 |
| AU2003233183A1 (en) | 2003-11-11 |
| KR20040108787A (ko) | 2004-12-24 |
| ITRM20020255A0 (it) | 2002-05-09 |
| ITRM20020255A1 (it) | 2003-11-10 |
| CN1652773A (zh) | 2005-08-10 |
| EP1501503A1 (de) | 2005-02-02 |
| CN100588398C (zh) | 2010-02-10 |
| US20050208125A1 (en) | 2005-09-22 |
| DE60325468D1 (de) | 2009-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |