ATE411317T1 - Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen - Google Patents

Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen

Info

Publication number
ATE411317T1
ATE411317T1 AT03793096T AT03793096T ATE411317T1 AT E411317 T1 ATE411317 T1 AT E411317T1 AT 03793096 T AT03793096 T AT 03793096T AT 03793096 T AT03793096 T AT 03793096T AT E411317 T1 ATE411317 T1 AT E411317T1
Authority
AT
Austria
Prior art keywords
compounds
carbinol
chemotherapeutic
metabolites
indole
Prior art date
Application number
AT03793096T
Other languages
German (de)
English (en)
Inventor
Ling Jong
Wan-Ru Chao
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Application granted granted Critical
Publication of ATE411317T1 publication Critical patent/ATE411317T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
AT03793096T 2002-08-20 2003-08-15 Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen ATE411317T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/224,979 US6800655B2 (en) 2002-08-20 2002-08-20 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

Publications (1)

Publication Number Publication Date
ATE411317T1 true ATE411317T1 (de) 2008-10-15

Family

ID=31946289

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03793096T ATE411317T1 (de) 2002-08-20 2003-08-15 Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen

Country Status (8)

Country Link
US (4) US6800655B2 (US20040157906A1-20040812-C00044.png)
EP (2) EP1623985B1 (US20040157906A1-20040812-C00044.png)
JP (3) JP4764629B2 (US20040157906A1-20040812-C00044.png)
AT (1) ATE411317T1 (US20040157906A1-20040812-C00044.png)
AU (1) AU2003263878A1 (US20040157906A1-20040812-C00044.png)
CA (1) CA2496203C (US20040157906A1-20040812-C00044.png)
DE (1) DE60324155D1 (US20040157906A1-20040812-C00044.png)
WO (1) WO2004018475A2 (US20040157906A1-20040812-C00044.png)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
CA2565721C (en) * 2004-05-06 2015-10-06 Bioresponse, L.L.C. Diindolymethane formulations for the treatment of leiomyomas
US20060100264A1 (en) * 2004-11-06 2006-05-11 Bjeldanes Leonard F 3,3'-Diindolylmethane immune activating compositions
EP1838303B1 (en) * 2004-12-30 2011-02-09 Bioresponse LLC Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions
JP5475234B2 (ja) 2005-01-21 2014-04-16 アステックス・セラピューティクス・リミテッド 医薬化合物
CA2609980C (en) 2005-05-27 2015-10-13 Queen's University At Kingston Treatment of protein folding disorders
CN1807413B (zh) * 2005-09-28 2010-05-05 中国医学科学院医药生物技术研究所 咔唑磺酰胺衍生物及其制备方法
EP2014652B1 (en) 2006-04-18 2014-08-06 Nippon Chemiphar Co., Ltd. Activating agent for peroxisome proliferator activated receptor
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
BRPI0717753B1 (pt) 2006-10-27 2022-04-12 Bioresponse, Llc Uso de uma composição compreendendo 50-250 mg de um ou mais indóis relacionados com dim e um ou mais agentes anti-protozoários, e, composição
WO2008144263A1 (en) * 2007-05-18 2008-11-27 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
US20100292316A1 (en) * 2007-07-18 2010-11-18 Research Development Foundation Improved therapeutic methods and compositions comprising chroman ring compounds
RU2501794C2 (ru) * 2008-04-15 2013-12-20 Ниппон Кемифар Ко., Лтд. Активирующий агент для рецептора, активируемого стимулирующими рост пероксисом агентами
EP2326327B1 (en) * 2008-09-17 2016-03-23 SRI International Analogs of indole-3-carbinol and their use as agents against infection
KR101477613B1 (ko) * 2009-03-31 2014-12-30 롬엔드하스전자재료코리아유한회사 신규한 유기 전자재료용 화합물 및 이를 포함하는 유기 전자 소자
US20120184590A1 (en) * 2009-04-09 2012-07-19 University Of Kansas Formulations of indole-3-carbinol derived antitumor agents with increased oral bioavailability
US20110092517A1 (en) * 2009-08-14 2011-04-21 Cerenis Therapeutics S.A. & Nippon Chemiphar Co., Ltd. Use of PPAR Delta Ligands for the Treatment or Prevention of Inflammation or Energy Metabolism/Production Related Diseases
US8153680B2 (en) * 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
DE102009052428A1 (de) * 2009-11-10 2011-05-12 Merck Patent Gmbh Verbindung für elektronische Vorrichtungen
US20130059850A1 (en) * 2010-05-06 2013-03-07 Merck Sharp & Dohme Corp. Aza-indole derivatives useful as modulators of faah
WO2012135133A1 (en) * 2011-04-01 2012-10-04 Sri International Lipoxygenase inhibitors
WO2015042170A1 (en) 2013-09-17 2015-03-26 Wayne State University Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds
CN104030964B (zh) * 2014-06-05 2016-06-29 天津科技大学 双吲哚类化合物及合成方法
US9969686B2 (en) * 2014-08-05 2018-05-15 Wisconsin Alumni Research Foundation Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
WO2016164770A1 (en) 2015-04-10 2016-10-13 Bioresponse, L.L.C. Self-emulsifying formulations of dim-related indoles
WO2017011920A1 (en) * 2015-07-22 2017-01-26 The Royal Institution For The Advancement Of Learning/Mcgill University Compounds and uses thereof in the treatment of cancers and other medical conditions
CN105218552B (zh) * 2015-09-30 2018-02-27 中国人民解放军军事医学科学院野战输血研究所 一种取代苯基二氢吲哚咔唑衍生物及其制备方法与应用
CN110698654B (zh) * 2018-07-10 2021-04-02 中国科学院长春应用化学研究所 基于三聚吲哚的超支化共轭聚电解质及其制备方法和用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1282451B (de) * 1965-09-01 1968-11-07 Kalle Ag Lichtempfindliche Schicht und Verfahren zur Herstellung fixierter Bilder
US4636820A (en) * 1980-03-06 1987-01-13 The Hilton-Davis Chemical Compositions, process and systems
ES2167303T3 (es) * 1986-10-28 2002-05-16 Ciba Sc Holding Ag Ftalidas cromogenas.
GB8713564D0 (en) 1987-06-10 1987-07-15 Kong Y C Synthesis
SK75289A3 (en) * 1988-02-10 1998-05-06 Hoffmann La Roche Substituted pyrroles, their use for producing a drug, and the drug on their base
US5086171A (en) * 1989-03-08 1992-02-04 Appleton Papers Inc. Bis-(indolyl)ethylenes
US5116978A (en) * 1989-03-08 1992-05-26 Appleton Papers Inc. Process for bis(indolyl)ethylene synthesis
JP3038064B2 (ja) * 1991-10-07 2000-05-08 日清製粉株式会社 インドール誘導体およびこれを有効成分とする抗潰瘍薬
EP0540468B1 (de) * 1991-10-30 1996-12-04 Ciba-Geigy Ag NIR-Farbstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung
US5206377A (en) * 1991-12-05 1993-04-27 Whitby Research, Inc. Compounds useful as antiproliferative agents
US5407102A (en) * 1994-02-15 1995-04-18 Freudinger; Mark J. Apparatus for dispensing a quantity of flowable material
US5948808A (en) * 1997-03-07 1999-09-07 The Texas A&M University System Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens
US5843607A (en) * 1997-10-02 1998-12-01 Xerox Corporation Indolocarbazole photoconductors
US5942340A (en) * 1997-10-02 1999-08-24 Xerox Corporation Indolocarbazole electroluminescent devices
DE59903921D1 (de) * 1998-05-04 2003-02-06 Zentaris Ag Indolderivate und deren verwendung zur behandlung von malignen und anderen, auf pathologischen zellproliferationen beruhenden erkrankungen
EP1093455B1 (en) * 1998-07-08 2004-09-22 Harbor Branch Oceanographic Institution, Inc. Bis-indole derivatives and their use as antiinflammatory agents
IT1317925B1 (it) 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.
IT1317926B1 (it) 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Derivati triciclici dell'indolo ad attivita' antiangiogenica.
JP2003346530A (ja) * 2002-05-23 2003-12-05 Nippon Sheet Glass Co Ltd 面状光源装置および画像読み取り装置
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

Also Published As

Publication number Publication date
JP2006500379A (ja) 2006-01-05
JP4699171B2 (ja) 2011-06-08
AU2003263878A1 (en) 2004-03-11
EP1623985A2 (en) 2006-02-08
DE60324155D1 (de) 2008-11-27
US7429610B2 (en) 2008-09-30
JP2010195840A (ja) 2010-09-09
EP1530572B1 (en) 2008-10-15
WO2004018475A3 (en) 2004-04-01
EP1530572A2 (en) 2005-05-18
JP5599236B2 (ja) 2014-10-01
US20040043965A1 (en) 2004-03-04
US20090023796A1 (en) 2009-01-22
WO2004018475A2 (en) 2004-03-04
US20040157906A1 (en) 2004-08-12
JP2006036796A (ja) 2006-02-09
US7666897B2 (en) 2010-02-23
US7078427B2 (en) 2006-07-18
CA2496203C (en) 2012-03-27
EP1623985A3 (en) 2011-06-08
CA2496203A1 (en) 2004-03-04
EP1623985B1 (en) 2016-02-17
US6800655B2 (en) 2004-10-05
US20060128785A1 (en) 2006-06-15
JP4764629B2 (ja) 2011-09-07

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