ATE406450T1 - Ein coumermycin/novobiocin-reguliertes genexpressionsystem - Google Patents
Ein coumermycin/novobiocin-reguliertes genexpressionsystemInfo
- Publication number
- ATE406450T1 ATE406450T1 AT04737796T AT04737796T ATE406450T1 AT E406450 T1 ATE406450 T1 AT E406450T1 AT 04737796 T AT04737796 T AT 04737796T AT 04737796 T AT04737796 T AT 04737796T AT E406450 T1 ATE406450 T1 AT E406450T1
- Authority
- AT
- Austria
- Prior art keywords
- coumermycin
- novobiocin
- target gene
- transactivator
- gene expression
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 2
- WTIJXIZOODAMJT-DHFGXMAYSA-N coumermycin A1 Chemical compound O([C@@H]1[C@H](C(O[C@@H](OC=2C(=C3OC(=O)C(NC(=O)C=4C(=C(C(=O)NC=5C(OC6=C(C)C(O[C@H]7[C@@H]([C@H](OC(=O)C=8NC(C)=CC=8)[C@@H](OC)C(C)(C)O7)O)=CC=C6C=5O)=O)NC=4)C)=C(O)C3=CC=2)C)[C@@H]1O)(C)C)OC)C(=O)C1=CC=C(C)N1 WTIJXIZOODAMJT-DHFGXMAYSA-N 0.000 title 1
- 108091023040 Transcription factor Proteins 0.000 abstract 3
- 102000040945 Transcription factor Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- WTIJXIZOODAMJT-WBACWINTSA-N [(3r,4s,5r,6s)-5-hydroxy-6-[4-hydroxy-3-[[5-[[4-hydroxy-7-[(2s,3r,4s,5r)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1h-pyrrole-2-carbonyl)oxyoxan-2-yl]oxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-4-methyl-1h-pyrrole-3-carbonyl]amino]-8-methyl-2-oxochromen- Chemical compound O([C@@H]1[C@H](C(O[C@H](OC=2C(=C3OC(=O)C(NC(=O)C=4C(=C(C(=O)NC=5C(OC6=C(C)C(O[C@@H]7[C@@H]([C@H](OC(=O)C=8NC(C)=CC=8)[C@@H](OC)C(C)(C)O7)O)=CC=C6C=5O)=O)NC=4)C)=C(O)C3=CC=2)C)[C@@H]1O)(C)C)OC)C(=O)C1=CC=C(C)N1 WTIJXIZOODAMJT-WBACWINTSA-N 0.000 abstract 2
- 238000006471 dimerization reaction Methods 0.000 abstract 2
- 230000035897 transcription Effects 0.000 abstract 2
- 238000013518 transcription Methods 0.000 abstract 2
- 108020000946 Bacterial DNA Proteins 0.000 abstract 1
- 230000004568 DNA-binding Effects 0.000 abstract 1
- YJQPYGGHQPGBLI-UHFFFAOYSA-N Novobiocin Natural products O1C(C)(C)C(OC)C(OC(N)=O)C(O)C1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-UHFFFAOYSA-N 0.000 abstract 1
- 108010034634 Repressor Proteins Proteins 0.000 abstract 1
- 102000009661 Repressor Proteins Human genes 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- YJQPYGGHQPGBLI-KGSXXDOSSA-N novobiocin Chemical compound O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 abstract 1
- 229960002950 novobiocin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47705503P | 2003-06-10 | 2003-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE406450T1 true ATE406450T1 (de) | 2008-09-15 |
Family
ID=33511833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04737796T ATE406450T1 (de) | 2003-06-10 | 2004-06-09 | Ein coumermycin/novobiocin-reguliertes genexpressionsystem |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7838501B2 (de) |
| EP (1) | EP1631671B1 (de) |
| JP (1) | JP4719147B2 (de) |
| AT (1) | ATE406450T1 (de) |
| AU (1) | AU2004245598B2 (de) |
| CA (1) | CA2523879C (de) |
| DE (1) | DE602004016152D1 (de) |
| WO (1) | WO2004108933A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4719147B2 (ja) | 2003-06-10 | 2011-07-06 | ナショナル リサーチ カウンシル オブ カナダ | クメルマイシン／ノボビオシン調節遺伝子発現系 |
| GB2404382B (en) | 2003-07-28 | 2008-01-30 | Oxitec Ltd | Pest control |
| GB2443186A (en) | 2006-10-25 | 2008-04-30 | Oxitec Ltd | Expression system for mediating alternative splicing |
| GB2500113A (en) | 2012-03-05 | 2013-09-11 | Oxitec Ltd | Arthropod male germline gene expression system |
| GB201303932D0 (en) | 2013-03-05 | 2013-04-17 | Oxitec Ltd | Muscle actin promoter |
| EP3122884B1 (de) * | 2014-03-26 | 2019-12-25 | Tocagen Inc. | Retroviraler vektor mit immunstimulierender aktivität |
| GB2526867A (en) | 2014-06-05 | 2015-12-09 | Oxitec Ltd | Gene expression system |
| BR112019002771A2 (pt) | 2016-08-12 | 2019-05-14 | Oxitec Ltd | polinucleotídeo de módulo de controle de união de doublesex, sistema de expressão de gene, plasmídeo vetor de expressão, inseto geneticamente engenheirado, métodos para produzir insetos geneticamente engenheirados, para cultivar seletivamente insetos macho geneticamente engenheirados, para reduzir uma população de inseto selvagem, para criar um mosquito aedes aegypti transgênico e para detectar a presença de uma molécula de dna, local alvo cromossômico de aedes aegypti, mosquito aedes aegypti geneticamente engenheirado, molécula de dna, e, kit de detecção de dna. |
| EP3293263A1 (de) * | 2016-09-07 | 2018-03-14 | Steinbeis Innovation gGmbH | Induzierbare genexpression durch lineare at-reiche dna-fragmente in säugetierzellen und zugehörige verfahren |
| AR117409A1 (es) | 2018-03-29 | 2021-08-04 | Oxitec Ltd | Noctuidas autolimitantes |
| KR20230128466A (ko) * | 2021-01-07 | 2023-09-05 | 내셔날 리서치 카운실 오브 캐나다 | 안정한 세포주를 사용한 생물학적 제제의 생산을 위한엄격하게-조절된 유도성 발현 시스템 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1064300A (en) * | 1962-12-17 | 1967-04-05 | Bristol Banyu Res Inst Ltd | A new antibiotic coumermycin |
| US6187757B1 (en) * | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
| CA2353800A1 (en) * | 1998-12-02 | 2000-06-08 | Trustees Of Boston University | Gene networks for control of gene expression |
| US6916846B2 (en) * | 2000-05-12 | 2005-07-12 | Merck & Co. Inc. | Coumermycin analogs as chemical dimerizers of chimeric proteins |
| JP4719147B2 (ja) | 2003-06-10 | 2011-07-06 | ナショナル リサーチ カウンシル オブ カナダ | クメルマイシン／ノボビオシン調節遺伝子発現系 |
-
2004
- 2004-06-09 JP JP2006515586A patent/JP4719147B2/ja not_active Expired - Fee Related
- 2004-06-09 CA CA2523879A patent/CA2523879C/en not_active Expired - Lifetime
- 2004-06-09 DE DE602004016152T patent/DE602004016152D1/de not_active Expired - Lifetime
- 2004-06-09 AU AU2004245598A patent/AU2004245598B2/en not_active Ceased
- 2004-06-09 WO PCT/CA2004/000854 patent/WO2004108933A1/en not_active Ceased
- 2004-06-09 US US10/559,411 patent/US7838501B2/en not_active Expired - Lifetime
- 2004-06-09 AT AT04737796T patent/ATE406450T1/de not_active IP Right Cessation
- 2004-06-09 EP EP04737796A patent/EP1631671B1/de not_active Expired - Lifetime
-
2010
- 2010-04-30 US US12/771,457 patent/US8377900B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004016152D1 (de) | 2008-10-09 |
| JP4719147B2 (ja) | 2011-07-06 |
| AU2004245598B2 (en) | 2009-01-08 |
| CA2523879A1 (en) | 2004-12-16 |
| US20070026486A1 (en) | 2007-02-01 |
| US8377900B2 (en) | 2013-02-19 |
| EP1631671B1 (de) | 2008-08-27 |
| US7838501B2 (en) | 2010-11-23 |
| US20100249220A1 (en) | 2010-09-30 |
| AU2004245598A1 (en) | 2004-12-16 |
| CA2523879C (en) | 2013-03-19 |
| WO2004108933A1 (en) | 2004-12-16 |
| JP2006526991A (ja) | 2006-11-30 |
| EP1631671A1 (de) | 2006-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |