ATE399990T1 - Fernfeld lichtmikroskopische methode und vorrichtung zur bestimmung von mindestens einem objekt kleiner als die benutzte wellenlänge - Google Patents
Fernfeld lichtmikroskopische methode und vorrichtung zur bestimmung von mindestens einem objekt kleiner als die benutzte wellenlängeInfo
- Publication number
- ATE399990T1 ATE399990T1 AT02785192T AT02785192T ATE399990T1 AT E399990 T1 ATE399990 T1 AT E399990T1 AT 02785192 T AT02785192 T AT 02785192T AT 02785192 T AT02785192 T AT 02785192T AT E399990 T1 ATE399990 T1 AT E399990T1
- Authority
- AT
- Austria
- Prior art keywords
- labelled
- elements
- far field
- field light
- labelling
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000003287 optical effect Effects 0.000 abstract 7
- 238000002372 labelling Methods 0.000 abstract 3
- 239000003550 marker Substances 0.000 abstract 3
- 238000005286 illumination Methods 0.000 abstract 2
- 230000003595 spectral effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/66—Trinkets, e.g. shirt buttons or jewellery items
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Optics & Photonics (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Theoretical Computer Science (AREA)
- Multimedia (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Microscoopes, Condenser (AREA)
- Length Measuring Devices By Optical Means (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32802101P | 2001-10-09 | 2001-10-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE399990T1 true ATE399990T1 (de) | 2008-07-15 |
Family
ID=23279165
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02785192T ATE399990T1 (de) | 2001-10-09 | 2002-10-09 | Fernfeld lichtmikroskopische methode und vorrichtung zur bestimmung von mindestens einem objekt kleiner als die benutzte wellenlänge |
AT08011879T ATE539345T1 (de) | 2001-10-09 | 2002-10-09 | Mikroskopisches weitfeldlichtverfahren |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08011879T ATE539345T1 (de) | 2001-10-09 | 2002-10-09 | Mikroskopisches weitfeldlichtverfahren |
Country Status (5)
Country | Link |
---|---|
US (1) | US7298461B2 (de) |
EP (2) | EP1983330B1 (de) |
AT (2) | ATE399990T1 (de) |
DE (1) | DE60227394D1 (de) |
WO (1) | WO2003031951A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6900435B1 (en) * | 1999-02-14 | 2005-05-31 | Nanoptics, Inc. | Deconvolving far-field images using scanned probe data |
US20100089804A1 (en) * | 2002-10-29 | 2010-04-15 | Claude Lambert | Method for identifying a substance or object using a plurality of excitation vectors |
FR2846445B1 (fr) * | 2002-10-29 | 2005-04-08 | Claude Lambert | Procede d'authentification par marquage ou tracage chimique d'un objet ou d'une substance. |
DE102004039035A1 (de) | 2004-04-07 | 2005-10-27 | EuroPhoton GmbH Gesellschaft für optische Sensorik | Verfahren und Vorrichtung zur Fluoreszenz-Lebensdauer-Imaging-Nanoskopie |
US20060083781A1 (en) * | 2004-10-14 | 2006-04-20 | Shastri V P | Functionalized solid lipid nanoparticles and methods of making and using same |
CA2600863A1 (en) | 2005-02-09 | 2007-08-23 | S3I, Llc | Method and system for detecting, classifying and identifying particles |
EP2453241B1 (de) | 2005-05-23 | 2017-01-11 | Harald F. Hess | Optische Mikroskopie mit phototransformierbaren optischen Markern |
DE102006009833B4 (de) * | 2006-03-01 | 2009-01-08 | Leica Microsystems Cms Gmbh | Verfahren und Mikroskop zur räumlich hochauflösenden Untersuchung von Proben |
WO2007129325A2 (en) * | 2006-05-09 | 2007-11-15 | Xceed Imaging Ltd. | Optical sub wavelength super resolution imaging system and method |
US8217992B2 (en) * | 2007-01-11 | 2012-07-10 | The Jackson Laboratory | Microscopic imaging techniques |
US8821799B2 (en) * | 2007-01-26 | 2014-09-02 | Palo Alto Research Center Incorporated | Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity |
DE102007033737A1 (de) * | 2007-07-18 | 2009-01-22 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zum Bestimmen eines Messwerts auf der Basis von Einzelmolekülereignissen |
US8947516B2 (en) * | 2007-09-26 | 2015-02-03 | Massachusetts Institute Of Technology | High-resolution 3D imaging of single semiconductor nanocrystals |
FR2922658B1 (fr) * | 2007-10-18 | 2011-02-04 | Centre Nat Rech Scient | Systeme d'illuminations structuree d'un echantillon |
WO2009115108A1 (en) | 2008-03-19 | 2009-09-24 | Ruprecht-Karls-Universität Heidelberg | A method and an apparatus for localization of single dye molecules in the fluorescent microscopy |
US7772569B2 (en) * | 2008-04-01 | 2010-08-10 | The Jackson Laboratory | 3D biplane microscopy |
DE102010007676A1 (de) * | 2010-02-10 | 2011-08-11 | Ohnesorge, Frank, Dr., 91054 | Konzept für lateral aufgelöste Fourier Transformations Infrarot Spektroskopie unterhalb/jenseits des Beugungslimits - Anwendungen für optisches (aber auch elektronisches) schnelles Auslesen von ultrakleinen Speicherzellen in Form von lumineszierenden Quantentrögen - sowie in der Biologie/Kristallographie |
WO2011112634A2 (en) | 2010-03-08 | 2011-09-15 | California Institute Of Technology | Molecular indicia of cellular constituents and resolving the same by super-resolution technologies in single cells |
EP2697770B1 (de) * | 2011-04-12 | 2015-07-01 | Tripath Imaging, Inc. | Verfahren zur herstellung von quantitativer videomikroskopie und zugehöriges system |
US9213106B2 (en) * | 2011-06-08 | 2015-12-15 | Battelle Memorial Institute | Method of measuring luminescence of a material |
US20140073520A1 (en) * | 2011-12-23 | 2014-03-13 | California Institute Of Technology | Imaging chromosome structures by super-resolution fish with single-dye labeled oligonucleotides |
DE102012216002B3 (de) * | 2012-05-18 | 2013-09-12 | Leica Microsystems Cms Gmbh | Schaltung und Verfahren zum Erzeugen von periodischen Steuersignalen sowie Mikroskop und Verfahren zum Steuern eines Mikroskops |
EP2757402B1 (de) * | 2013-01-22 | 2016-03-30 | FEI Company | Verfahren zum Betrachten von Proben mit einem Fluoreszenzmikroskop |
WO2015020814A1 (en) | 2013-08-08 | 2015-02-12 | Applied Materials, Inc. | Photonic activation of reactants for sub-micron feature formation using depleted beams |
DE102013019348A1 (de) * | 2013-08-15 | 2015-02-19 | Carl Zeiss Microscopy Gmbh | Hochauflösende Scanning-Mikroskopie |
DE102013019347A1 (de) * | 2013-08-15 | 2015-02-19 | Carl Zeiss Microscopy Gmbh | Hochauflösende Scanning-Mikroskopie |
US9921161B1 (en) * | 2015-01-08 | 2018-03-20 | Daniel Feldkhun | Structured light active localization microscopy |
DE102015105018A1 (de) | 2015-03-31 | 2016-10-06 | Laser-Laboratorium Göttingen e.V. | Verfahren und Rasterfluoreszenzlichtmikroskop zum mehrdimensional hochauflösenden Abbilden einer Struktur oder eines Wegs eines Partikels in einer Probe |
DE102017107915A1 (de) * | 2016-07-18 | 2018-01-18 | Carl Zeiss Meditec Ag | System zur Augentherapie mittels Gewebebearbeitung durch nichtlineare Wechselwirkung |
US11506877B2 (en) | 2016-11-10 | 2022-11-22 | The Trustees Of Columbia University In The City Of New York | Imaging instrument having objective axis and light sheet or light beam projector axis intersecting at less than 90 degrees |
DE102017111578A1 (de) | 2017-05-29 | 2018-11-29 | Wladimir Schaufler | Verfahren zur Unterscheidung einzelner fluoreszierender Markierungsstoffmoleküle in der SPDM-Lokalisationsmikroskopie durch deren zeitliches Langzeit-Emissionsverhalten über 10ms |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4216949C2 (de) | 1992-05-22 | 1997-07-24 | Christoph Prof Dr Dr Cremer | Nichtenzymatisches Verfahren zur In-situ-Hybridisierung bei spezifischen Proben |
US6259104B1 (en) * | 1994-07-15 | 2001-07-10 | Stephen C. Baer | Superresolution in optical microscopy and microlithography |
EP0732584A3 (de) | 1995-03-16 | 1999-06-30 | International Business Machines Corporation | Verfahren und Aufbau zur Identifizierung einer Codesequenz eines Biomoleküls |
US6017434A (en) * | 1995-05-09 | 2000-01-25 | Curagen Corporation | Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments |
US6104945A (en) * | 1995-08-01 | 2000-08-15 | Medispectra, Inc. | Spectral volume microprobe arrays |
EP0881322B1 (de) | 1996-07-19 | 2005-09-28 | Toray Industries, Inc. | Mittel zur verringerung der reibung für sicherheitsgurte |
US6424421B1 (en) | 1996-12-23 | 2002-07-23 | Ruprecht-Karls-Universität Heidelberg | Method and devices for measuring distances between object structures |
WO1998035012A2 (en) * | 1997-02-12 | 1998-08-13 | Chan Eugene Y | Methods and products for analyzing polymers |
EP0996854A1 (de) | 1997-07-10 | 2000-05-03 | Ruprecht-Karls-Universität Heidelberg | Wellenfeld-mikroskop,verfahren für ein wellenfeldmikroskop einschliesslich dna-sequenzierung und kalibrierungsverfahren für die wellenfeldmikroskopie |
DE10052583B4 (de) | 2000-10-23 | 2011-07-14 | Ruprecht-Karls-Universität Heidelberg, 69120 | Verfahren zur Optimierung der molekularen Multiplex-Diagnostik von Microtissue Arrays mit Hilfe von Virtual Cell Nucleus Imageing |
DE10052823B4 (de) | 2000-10-24 | 2014-11-20 | Ruprecht-Karls-Universität Heidelberg | Verfahren zur lichtmikroskopischen Analyse der Topologie molekularer Strukturen in Rasteranordnungen |
-
2002
- 2002-10-09 AT AT02785192T patent/ATE399990T1/de active
- 2002-10-09 WO PCT/EP2002/011343 patent/WO2003031951A1/en active IP Right Grant
- 2002-10-09 DE DE60227394T patent/DE60227394D1/de not_active Expired - Lifetime
- 2002-10-09 US US10/492,266 patent/US7298461B2/en not_active Expired - Fee Related
- 2002-10-09 EP EP08011879A patent/EP1983330B1/de not_active Expired - Lifetime
- 2002-10-09 EP EP02785192A patent/EP1436597B1/de not_active Expired - Lifetime
- 2002-10-09 AT AT08011879T patent/ATE539345T1/de active
Also Published As
Publication number | Publication date |
---|---|
DE60227394D1 (de) | 2008-08-14 |
US20050059681A1 (en) | 2005-03-17 |
WO2003031951A1 (en) | 2003-04-17 |
EP1436597B1 (de) | 2008-07-02 |
US7298461B2 (en) | 2007-11-20 |
EP1983330B1 (de) | 2011-12-28 |
EP1983330A1 (de) | 2008-10-22 |
ATE539345T1 (de) | 2012-01-15 |
EP1436597A1 (de) | 2004-07-14 |
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